고다은 교수
Dae Eun Ko
연세대학교 마취통증의학과 · 의학
연구실 소개
고다은 교수의 연구실은 주로 암 생물학과 신장·혈관 수술 분야에서의 생물학적 마커와 예후 요법을 중심으로 연구를 진행하고 있습니다. 특히 대장암에서의 미세RNA 메틸화와 유전자 발현의 연관성, 복부 동맥aneurysm 수술 환자의 혈액 수치(중성구/림프구 비율, 혈장판소체량, 알부민 등)가 1년 생존율에 미치는 영향을 규명하고 있습니다. 또한 신장 이식 환자의 예후를 예측할 수 있는 혈액 생화학적 지표(알카라인 인산효소 등)의 임상적 유용성도 탐색하고 있습니다. 이는 임상에서의 정밀의료 및 개인 맞춤 치료 전략 수립에 기여하고자 하는 목표를 가지고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
10Colorectal cancer (CRC) is one of the most common types of cancers, as evidenced by the >1.2 million patient diagnoses and 600,000 mortalities globally each year. Recently, the microRNA (miR/miRNA)-34 miRNA precursor family was revealed to participate in the tumor protein (TP)-53 pathway, which is frequently involved in CRC. Furthermore, the expression of miR-34 is reportedly regulated by DNA methylation. Accordingly, the present study investigated the correlation between the methylation status
Because of the rapid increase of mobile traffic, flexible broadband supportive unmanned aerial vehicle (UAV)‐based 6G mobile networks using free space optical (FSO) links have been recently proposed. Considering the advancements made in UAVs, big data processing, and artificial intelligence precision control technologies, the formation of an additional wireless network based on UAV aerial platforms to assist the existing fixed base stations of the mobile radio access network is considered a high
Objectives: To investigate if preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), or mean platelet volume (MPV) could be used to predict 1-year mortality in patients undergoing open abdominal aortic aneurysm (AAA) repair. Methods: We retrospectively reviewed 382 patients who underwent open AAA repair between January 2008 and July 2019. We divided the patients into two groups based on 1-year mortality and compared the preoperative NLR, PLR, and MPV. The patients
BACKGROUND: Perioperative hypoalbuminemia has a prognostic effect on mortality and morbidity in various cohorts. Patients undergoing open repair of ruptured abdominal aortic aneurysms (rAAA) are at a high risk of hypoalbuminemia due to bleeding and underlying diseases. Hence, this study aimed to investigate the predictive value of immediate postoperative hypoalbuminemia for the risk for acute kidney injury (AKI) in patients undergoing open rAAA repair. METHODS: We retrospectively reviewed 143 pa
The dangerous conditions of pregnancy with the signs of liver failure include hyperemesis gravidarum, cholestatic syndromes of pregnancy, HELLP syndrome (hemolysis, elevated liver enzymes, low platelets), and the most rarely observed, acute fatty liver of pregnancy (AFLP) It is a rare complication of pregnancy but is potentially fatal for both mother and fetus. AFLP may begin innocuously with mild symptoms and liver-enzyme abnormalities, but, if left untreated, can progress to jaundice, liver fa
Serum alkaline phosphatase (ALP) levels are related to high-turnover bone disease and reflect vascular calcification and inflammation. ALP has been reported to have a prognostic impact in various cohorts including chronic kidney disease. This study investigated whether preoperative serum ALP level could be used for predicting mortality in patients undergoing kidney transplantation. We retrospectively reviewed 1,718 patients who underwent kidney transplantation between November 2005 and June 2017
Brugada syndrome is an arrhythmic syndrome characterized by right bundle branch block, ST segment elevation in the precordial lead (V1-V3), and sudden death caused by ventricular fibrillation, which is not effectively prevented by anti-arrhythmic drug therapy. We are reporting a 30-year-old male patient with Brugada syndrome who got an exploratory laparotomy and a tenorrhaphy due to stab wound which was managed with general anesthesia and brachial plexus block without any complications.
Abstract Serum alkaline phosphatase (ALP) levels are related to high-turnover bone disease and reflect vascular calcification and inflammation. ALP has been reported to have a prognostic impact in various cohorts including chronic kidney disease. This study investigated whether preoperative serum ALP level could be used for predicting mortality in patients undergoing kidney transplantation. We retrospectively reviewed 1,718 patients who underwent kidney transplantation between November 2005 and
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