유대현 교수
Dae‐Hyun Yoo
연세대학교 성형외과 · 공학
연구실 소개
유대현 교수의 연구실은 의료 및 생물의학 분야에서 신뢰할 수 있는 세포 기반 치료법과 수술 기술의 발전을 목표로 합니다. 주로 혈액세포와 면역세포의 상호작용을 규명하는 면역학적 메커니즘 연구와 함께, 치유 과정에서의 성장인자 작용, 특히 EGF의 역할을 중심으로 피부 재생 및 흉터 형성 억제에 관한 기초 연구를 수행하고 있습니다. 또한, 유전자 조절, 세포 치료, 그리고 최신 수술 기술(예: 로봇 수술)을 접목한 정밀 외과적 치료법 개발에도 주력하고 있습니다. 특히 치료적 효과를 높이기 위한 생체 재료 및 장치 설계, 예를 들어 유기 발광 다이오드 기반의 신소재 개발도 함께 진행 중입니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Purpose: Most studies on immune tolerance of mesenchymal stem cells (MSCs) have been performed using MSCs derived from bone marrow, cord blood, or adipose tissue. MSCs also exist in the craniofacial area, specifically in teeth. The purpose of this study was to evaluate the mechanisms of immune tolerance of dental pulp-derived MSC (DP-MSC) in vitro and in vivo. Materials and Methods: We isolated DP-MSCs from human dental pulp and co-cultured them with CD4+ T-cells. To evaluate the role of cytokin
A visible cutaneous scar develops from the excess formation of immature collagen in response to an inflammatory reaction. This study examined the role of epidermal growth factor (EGF) in the formation of cutaneous scars. Twenty Crl:CD-1 (ICR)mice were used and 2 full-thickness skin wounds were made on the dorsum of each mouse. One of the wounds was treated with recombinant human EGF by local application and the other was treated with saline for control until complete healing was achieved. The EG
Robotic surgical systems enhance surgical accuracy and efficiency by applying advanced technologies such as artificial arm joints to provide higher degrees of freedom of movement and high-quality three-dimensional images. However, the application of robotic surgical systems to breast surgery has not been widely attempted. The robotic system would improve cosmesis by enabling surgery using a single small incision. We report the first case of a gasless robot-assisted nipple-sparing mastectomy and
The electroluminescent characteristics of white organic light-emitting diodes (WOLEDs) were investigated including single emitting layer (SEL) with an ADN host and dopants; BCzVBi, C545T, and DCJTB for blue, green and red emission, respectively. The structure of the high efficiency WOLED device was; ITO/NPB(700 Å)/ADN: BCzVBi-7%:C545T-0.05%:DCJTB-0.1%(300 Å)/Bphen(300 Å)/Liq(20 Å)/Al(1200 Å) for mixing three primary colors. Luminous efficiency was 9.08 cd/A at 3.5 V and Commission Intenationale
본 연구는 노인의 건강에 중요한 변수인 사회적 관계에 대한 예측 요인인 주관적 건강, 일상생활 및 운동능력이 미치는 영향에 대해 알아보고자 하는데 그 목적이 있다. 조사대상은 서울 및 수도권에 거주하는 65세 이상 노인으로 노인복지관과 경로당 이용노인을 중심으로 하였다. 표집은 지역별 할당표집을 통해 서울 강북 복지관 4곳, 경로당 4곳, 강남 복지관 4곳, 경로당 4곳에 설문지를 배포하여 총 598부를 수거하였다. 본 연구의 목적을 달성하기 위해서 노인의 주관적 건강상태, 일상생활 및 운동능력, 사회적 관계에 대한 가설을 설정하고 이를 실증적으로 검증하였다. 실증분석의 결과 본 연구에서 제안한 모델은 적합한 것으로 나타났으며, 이를 요약하면 다음과 같은 결과를 도출하였다. 첫째, 노인의 주관적 건강은 일상생활 및 운동능력에 영향을 미친다. 둘째, 노인의 주관적 건강은 사회적 관계에 영향을 미친다. 셋째, 노인의 운동능력은 사회적 관계에 영향을 미친다.
Purpose: Breast volume assessment is one of the most important steps during implant-based breast reconstruction because it is critical in selecting implant size. According to previous studies, there is a close relationship between the mastectomy specimen weight and resected breast volume. The aim of this study was to evaluate long-term patient satisfaction with implantbased breast reconstruction guided by the ratio of implant volume to mastectomy specimen weight. In doing so, we describe the ide
The purpose of this study was to investigate the effects of color commentary on satisfaction in commentator, viewing flow and re-viewing intention, based on disposition theory. This study assumed that color commentary(biased toward home team) have a more positive impact on audiences satisfaction in commentator, viewing flow and re-viewing intention significantly, compared to objective commentary and color commentary(biased toward away team). For the current study, a 3(manipulated video: neutral,
The purpose of this study was to examine the relationship among the life-style, career decision level, career preparation behavior for collegiate that helps the career decision and career preparation for collegiate athletes after graduating school and provides the basic actual proof data for creating program of career decisional preparation to coach. The subject of this study was selected using the convenience sampling method from chosen athletes population attending at the collegiate in Seoul a
High contrast blue organic light-emitting diodes were fabricated using an inorganic multilayer of NPB (700 Å)/MADN (200 Å)/Alq3 (300 Å)/LiF (10 Å)/Al (70 Å)/ZnSe (300 Å)/Al (1000 Å). The optical and electrical characteristics were measured and compared to conventional organic light-emitting devices (OLEDs) and OLEDs with polarizers. OLEDs with the metal multilayer cathodes had an improved contrast ratio of 135∶1 compared to 104∶1 for OLEDs with polarizers. In addition, the multilayer OLEDs had a
Summary We consider the problem of security in the CDMA. CDMA system has wireless channels to transmit voice or data. By this reason, CDMA communication has a possibility of being eavesdropped by someone. It is known that eavesdropping in CDMA system is impossible because the voice data spreads with the PN. However, we can eavesdrop the CDMA data using FCM protocol in case that we know the ESN and the MIN. In CDMA system, ESN and MIN are exposed to the wireless channel. In this paper, we analyze
Patients who have a lower facial asymmetry with compensatory head posture (developmental facial asymmetry) may have minortemporomandibular (T-M) joint problems and tend to mask their asymmetry by tilting the head for camouflage of their chin deviation. However, this compensatory head posture can give the impression of orbital dystopia and c spine deviation. When thesepatients undergo bimaxillary orthognathic surgery, orbital canting and head tilting improves gradually without the need for camouf
Background Robots have allowed head and neck surgeons to extirpate oropharyngeal tumors safely without the need for lip-split incision or mandibulotomy. Using robots in oropharyngeal reconstruction is new but essential for oropharyngeal defects that result from robotic tumor excision. We report our experience with robotic free-flap reconstruction of head and neck defects to exemplify the necessity for robotic reconstruction. Methods We investigated head and neck cancer patients who underwent abl
This paper discusses the implementation of a rehabilitation center based on a ubiquitous sensor network. This paper discusses the implementation of a rehabilitation center based on a ubiquitous sensor network. We recognize that certain mild conditions requiring rehabilitation may be treated with minimal human supervision. In place of this constant human supervision, a variety of sensors are used to monitor the patient and rehabilitation progress. These sensors send data through a wireless Zigbee
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