김도형 교수

Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

The direct and indirect pathways of the basal ganglia have long been thought to mediate behavioral promotion and inhibition, respectively. However, this classic dichotomous model has been recently challenged. To better understand neural processes underlying reward-based learning and movement control, we recorded from direct (dSPNs) and indirect (iSPNs) pathway spiny projection neurons in the dorsomedial striatum of D1-Cre and D2-Cre mice performing a probabilistic Pavlovian conditioning task. dS

Einheitliche 3 nm große Cerdioxidnanopartikel können vor ischämischen Hirninfarkten schützen, indem sie reaktive Sauerstoffspezies (ROS) abfangen und die Apoptose zurückdrängen. PEGylierte Cerdioxidnanopartikel waren in vitro gegen ROS-induzierten Zelltod wirksam. Optimale Dosen solcher Nanopartikel verringerten das Infarktvolumen und verlangsamten den ischämischen Zelltod. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-revie

AIMS: Although use of antithrombotic agents is recommended after ischaemic stroke or transient ischaemic attack (TIA), long-term outcome of secondary prevention between stroke subtypes has not yet been explored. METHODS AND RESULTS: We used data from the Korean Stroke Registry (KSR), a nationwide, multicentre, prospective registry for acute stroke patients. Patients with acute ischaemic stroke or TIA within 7 days of onset were consecutively enrolled between January 2002 and September 2010. A to

Background and Purpose- Two large-scale randomized controlled trials of recurrent stroke prevention suggest that dual antiplatelet therapy with clopidogrel plus aspirin is beneficial for prevention of subsequent ischemic events. There is a paucity of data, however, on the efficacy or effectiveness of such an approach in the treatment of stroke patients with symptomatic large artery atherosclerotic occlusive disease. Methods- We used a multicenter stroke registry database (Clinical Research Colla

BACKGROUND: Adverse effect of excessive work on health has been suggested previously, but it was not documented in cerebrovascular diseases. AIM: The authors investigated whether excessive working conditions would associate with increased risk of haemorrhagic stroke. METHODS: A nationwide matched case-control study database, which contains 940 cases of incident haemorrhagic stroke (498 intracerebral haemorrhages and 442 sub-arachnoid haemorrhages) with 1880 gender- and age- (± 5-year) matched co

The frontal cortex-basal ganglia circuit plays an important role in interval timing. We examined neuronal discharges in the dorsomedial and dorsolateral striatum (DMS and DLS) in rats performing a temporal categorization task and compared them with previously recorded neuronal activity in the medial prefrontal cortex (mPFC). All three structures conveyed significant temporal information, but striatal neurons seldom showed the prolonged, full-interval spanning ramping activity frequently observed

We documented that the severity of white matter lesions is related to the occurrence and amount of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage cases.

Fimasartan is a newly developed angiotensin receptor blocker, which may have protective effects during myocardial infarction or atherosclerosis. In this context, we investigated the effects of long-term treatment with low-dose fimasartan on focal ischemia in rat brain. We induced focal ischemia in brain by transient intraluminal occlusion of middle cerebral artery (MCA) and administered low-dose (0.5 mg/kg) or regular doses (1 or 3 mg/kg) of fimasartan via intravenous routes. After the administr

BACKGROUND AND PURPOSE: The CHADS(2) (an acronym for congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, and prior stroke or transient ischemic attack or thromboembolism) score is a widely used system for estimating the risk of stroke in patients with atrial fibrillation. However, how the CHADS(2) score is related to stroke severity and outcome in patients with strokes due to atrial fibrillation has not yet been elucidated. METHODS: We enrolled patients with atrial fibrilla

Abstract

Ceroxidnanopartikel können als Radikalfänger für reaktive Sauerstoffspezies wirken. In der Zuschrift auf S. 11201 ff. zeigen S.-H. Lee, T. Hyeon et al., dass einheitliche 3 nm große PEGylierte Ceroxidnanopartikel vor ischämischem Hirninfarkt schützen und das Ausmaß der Apoptose verringern können. Optimale Dosen der Ceroxidnanopartikel verringern das Infarktvolumen und verlangsamen den ischämischen Zelltod. Die Nanopartikel wandern in vivo zum Ort des Infarkts.

Ceria nanoparticles are known to exhibit free-radical scavenging activity by reversibly binding oxygen. In their Communication on page 11039 ff., S.-H. Lee, T. Hyeon, et al. show that discrete, uniform 3 nm PEGylated ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species and reducing apoptosis. Optimal doses of ceria nanoparticles reduce infarct volumes and the rate of ischemic cell death, and target the infarct site in vivo.