이동엽 교수
Dong Yul Lee
성균관대학교 화학공학부 · 의학
연구실 소개
이동엽 교수의 연구실은 노화와 수명 연장 메커니즘을 이해하기 위해 유전자, 대사 및 환경 요인 간의 상호작용을 중심으로 연구를 진행하고 있습니다. 주로 초파리(Caenorhabditis elegans)를 모델 생물로 활용해 식이요법, 체온, 지방 대사 조절 인자(SREBP, MDT-15) 등이 수명에 미치는 영향을 분석하고 있으며, 이는 인간의 노화 및 대사질환 예방에 응용 가능한 기초 데이터를 제공합니다. 또한 운동이 중년 여성의 체 composition과 혈중 지질 수치에 미치는 영향을 실험적으로 규명함으로써 건강한 노화를 위한 실용적 운동 전략 개발에도 기여하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15In Brief Study Design. Validation of a translated, culturally adapted questionnaire. Objectives. To translate and culturally adapt a Korean version of the Oswestry Disability Index (ODI) and to validate its use in Korean patients. Summary of Background Data. The ODI is one of the most widely used and validated instruments for measuring disability in spinal disorders. However, no validated Korean version of the index was available at the time our study was initiated. Methods. The study was carrie
Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator-15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in Caenorhabditis elegans. Up-regulation of the SREBP/MDT-15 transcription factor complex was necessary and sufficient for alleviating the life-shortening effect of a
Nutrients including carbohydrates, proteins, lipids, vitamins, and minerals regulate various physiological processes and are essential for the survival of organisms. Reduced overall caloric intake delays aging in various organisms. However, the role of each nutritional component in the regulation of lifespan is not well established. In this review, we describe recent studies focused on the regulatory role of each type of nutrient in aging. Moreover, we will discuss how the amount or composition
Low temperatures delay aging and promote longevity in many organisms. However, the metabolic and homeostatic aspects of low-temperature-induced longevity remain poorly understood. Here, we show that lipid homeostasis regulated by Caenorhabditis elegans Mediator 15 (MDT-15 or MED15), a transcriptional coregulator, is essential for low-temperature-induced longevity and proteostasis. We find that inhibition of mdt-15 prevents animals from living long at low temperatures. We show that MDT-15 up-regu
[Purpose] This study was conducted to identify the effects of walking on the body composition, health-related physical fitness, and serum lipids as part of efforts to encourage middle-aged people to participate in walking as a regular and sustainable exercise. [Methods] This study was conducted as a pretest-posttest control group study. The study period was for 12 weeks from January to March 2010. The participants were 43 middle-aged women (age range: 40-55 years) with body fat rates over 30%. S
Performing the bridging exercise with abdominal drawing-in maneuver is a more effective way to strengthen the abdominal muscles and stabilize the body than bridging exercise only.
For optimal performance and effect of selected squat exercises, the speed and ground environment should be taken into consideration.
Due to the urgency of controlling the coronavirus disease 2019 pandemic, coronavirus disease 2019 messenger ribonucleic acid (mRNA) vaccines have been expeditiously approved and introduced in several countries without sufficient evaluation for adverse events. We analyzed adverse events among Korean healthcare workers who received all 3 doses of the BNT162b2 mRNA vaccine. This survey was conducted among hospital workers of Inha University Hospital who had received the BNT162b2 mRNA vaccine for th
본 연구는 가상현실을 이용한 재활운동을 적용하여 뇌졸중 환자의 보행시 에너지 소모의 효율성에 효과가 있는가를 알아보고자 하였다. 뇌졸중으로 6개월 이상 장애를 가진 32명이 연구에 참여하였고 가상현실군 16명과 대조군 16명으로 나누었다. 가상현실군은 가상현실을 이용한 게임장치를 이용하여 1시간씩 주 3회를 6주간 실시하였다. 대조군은 운동의 적용없이 평상시 생활을 유지하도록 하였다. 운동 전과 후에 심박동수와 보행속도를 측정하여 에너지소모지수를 산출하여 효과를 비교하였다. 통계처리 방법으로 운동 전후 차이를 검증하기 위하여 대응표본 t 검정을 실시하였고 그룹간 차이 검증을 위하여 독립표본 t 검정을 실시하였다. 모든 통계적 유의수준은 0.05로 하였다. 연구결과 대조군과 비교하여 가상현실군에서 보행시 에너지소모지수가 유의하게 감소하였다(p<.05). 결론적으로 가상현실을 이용한 재활운동이 뇌졸중 환자의 보행시 에너지 소모에 있어 효과적이며 보행능력의 향상에 효과적인 방법임을 확인하
The application of transcutaneous electrical nerve stimulation (TENS) enhances muscle weakness and static balance by muscle fatigue. It was said that TENS affects decrease of the postural sway. On the other hand, the applications of TENS to separate dorsi-plantar flexor and the comparison with and without visual input have not been studied. Thus, the aim of this study was to compare the effects of TENS on fatigued dorsi-plantar flexor with and without visual input. 13 healthy adult males and 12
The purpose of this study was to investigate the relations between financial stress, depression, and conjugal affection and the motivation for rehabilitation. One hundred eighty-six stroke patients were included in the study and a survey with 65 questions was used. The survey includes questions to evaluate personal factors, characteristics related with physical therapy, characteristics related with disease, depression, conjugal affection, and motivation for rehabilitation. Education, employment,
Background/Objectives: The objective of this research is to grasp the middle-aged working women’s physical condition, climacteric symptom, job-family complications, social support and health related quality of life, and its influence factor. Methods/Statistical Analysis: This research is the descriptive interrelation to grasp the factor that affects the health related quality of life of middle-aged working women, and targeted to 141 middle-aged career women living in C province and D province. T
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