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이은화 교수

Eun Hwa Lee

연세대학교 내과 · 의학

연구실 소개

이은화 교수의 연구실은 주로 감염성 질환의 조기 진단 및 중증 질환에서의 생체지표 연구를 핵심으로 삼고 있으며, 특히 혈액에서의 염증 반응을 평가하는 생물학적 마커(예: CRP, PCT, IL-6)의 유용성과 한계를 분석합니다. 또한 심각한 감염성 질환인 패혈증의 위험 요인과 예후를 규명하고, 심부전 환자에서 ECMO를 통한 생명유지 치료 중 발생할 수 있는 혈행감염의 원인 미생물과 관련 요인을 조사합니다. 최근에는 HIV 환자에서의 비결핵성 미세박테리아 감염 및 식물-균 상호작용에서의 균류 다양성과 기능성에 이르기까지 다양한 생물학적 상호작용 메커니즘을 탐구하고 있습니다.

패혈증생체지표감염성 질환균-식물 상호작용생명유지 치료

연구 현황

논문 수
82
총 인용 수
1,446
최근 5년 논문
44
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
44총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
259총합
20222023202420252026

주요 논문

15
1
리뷰|인용수 195·2013
Diversity of Arbuscular Mycorrhizal Fungi and Their Roles in Ecosystems
Eun Hwa Lee, Ju-Kyeong Eo, Kang-Hyeon Ka, Ahn-Heum Eom
SJR Q2MycobiologyOA

Arbuscular mycorrhizal fungi (AMF) have mutualistic relationships with more than 80% of terrestrial plant species. This symbiotic relationship is ancient and would have had important roles in establishment of plants on land. Despite their abundance and wide range of relationship with plant species, AMF have shown low species diversity. However, molecular studies have suggested that diversity of these fungi may be much higher, and genetic variation of AMF is very high within a species and even wi

Plant ScienceAgricultural and Biological Sciences
2
논문|인용수 133·2016
Hydrodeoxygenation of guaiacol over Pt loaded zeolitic materials
Eun Hwa Lee, Rae-su Park, Hannah Kim, Sung Hoon Park, Sang‐Chul Jung, Jong‐Ki Jeon, Sang Chai Kim, Young‐Kwon Park
SJR Q1Journal of Industrial and Engineering Chemistry
Mechanical EngineeringEngineering
3
리뷰|인용수 40·2019
Reciprocal interactions across and within multiple levels of monoamine and cortico-limbic systems in stress-induced depression: A systematic review
Eun Hwa Lee, Pyung‐Lim Han
SJR Q1Neuroscience & Biobehavioral Reviews
Cognitive NeuroscienceNeuroscience
4
논문|인용수 24·2022
Discrepancy of C-Reactive Protein, Procalcitonin and Interleukin-6 at Hospitalization: Infection in Patients with Normal C-Reactive Protein, Procalcitonin and High Interleukin-6 Values
Eun Hwa Lee, Kyoung Hwa Lee, Young Goo Song, Sang Hoon Han
SJR Q1Journal of Clinical MedicineOA

C-reactive protein (CRP) or procalcitonin (PCT) alone has limitations in the early detection of infection or inflammation due to shortcomings in specificity and varied cut-off values. Recently, interleukin (IL)-6 has been assessed, but it is not known to what extent the three values are homogeneous in reality. This retrospective study was conducted with two large datasets (discrepancy set with results within 24 h of admission [7149 patients] and follow-up set until 2 weeks of hospital stay [5261

EpidemiologyMedicine
5
논문|인용수 23·2022
Clinical and microbiological characteristics of and risk factors for bloodstream infections among patients with extracorporeal membrane oxygenation: a single-center retrospective cohort study
Eun Hwa Lee, Ki Hyun Lee, Se Ju Lee, Jin Nam Kim, Yae Jee Baek, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon‐Sup Yeom, Young Goo Song, Jung Ho Kim
SJR Q1Scientific ReportsOA

Extracorporeal membrane oxygenation (ECMO) provides hemodynamic and oxygenation support to critically ill patients. Due to multiple catheter cannulations, patients on ECMO are vulnerable to bloodstream infections (BSIs). We aimed to investigate the incidence, clinical characteristics, risk factors, and microorganisms associated with BSIs during ECMO. This single-center retrospective cohort study was conducted between January 2015 and May 2021. Patients aged 18 years or older with an ECMO duratio

Biomedical EngineeringEngineering
6
논문|인용수 12·2011
Radical-mediated intramolecular C–C bond formation and the deoxygenation of alcohols under solvent-free conditions with tributyl methyl ammonium hypophosphite
Eun Hwa Lee, Dae Hyan Cho, Apuri Satyender, Doo Ok Jang
SJR Q3Tetrahedron Letters
Organic ChemistryChemistry
7
논문|인용수 11·2022
Clinical characteristics of nontuberculous mycobacterial disease in people living with HIV/AIDS in South Korea: A multi-center, retrospective study
Eun Hwa Lee, BumSik Chin, Young Keun Kim, Jin Sae Yoo, Young-Hwa Choi, Subin Kim, Ki Hyun Lee, Se Ju Lee, Jin Nam Kim, Yae Jee Baek, Jung Ho Kim, Jin Young Ahn
SJR Q1PLoS ONEOA

With the introduction of combination antiretroviral therapy (cART), the prevalence of human immunodeficiency virus (HIV)-associated nontuberculous mycobacteria (NTM) disease has declined. However, NTM diseases still occur in people living with HIV/acquired immunodeficiency syndrome (AIDS) (PLWHA). We analysed the clinical and microbiological features of NTM diseases in PLWHA in South Korea. PLWHA who were diagnosed with NTM diseases between January 2000 and March 2021 were retrospectively enroll

EpidemiologyMedicine
8
논문|인용수 10·2014
In Situ Catalytic Pyrolysis of Miscanthus Over Modified SBA-15 Catalysts Using Py-GC/MS
Eun Hwa Lee, Mi-Jin Jeon, Jong‐Ki Jeon, Dong Jin Suh, Sung Hoon Park, Bora Seo, Sang Hoon Joo, Young‐Kwon Park
Journal of Nanoscience and Nanotechnology

Various SBA-15-based catalysts, Si-SBA-15, Pt/Si-SBA-15, Al-SBA-15, and Pt/Al-SBA-15, were applied to the catalytic pyrolysis of miscanthus. Pt nanoparticles with three different sizes, 1.7 nm, 2.9 nm, and 7.1 nm, were used to synthesize Pt/Si-SBA-15 and Pt/Al-SBA-15. Pyrolysis-gas chromatography/mass spectrometry was used for the pyrolysis experiments. The catalysts were characterized by X-ray diffraction patterns, transmittance electron microscopy, N2 adsorption-desorption, and Brunaure-Emmett

Biomedical EngineeringEngineering
9
논문|인용수 7·2025
Connection between Impaired Fasting Glucose or Type 2 Diabetes Mellitus and Sepsis: A 10-Year Observational Data from the National Health Screening Cohort
Eun Hwa Lee, Kyoung Hwa Lee, Kyu‐na Lee, Yebin Park, Kyungdo Han, Sang Hoon Han
SJR Q1Diabetes & Metabolism JournalOA

BACKGRUOUND: The mortality of sepsis without direct drugs is high. The association between prediabetes, based on a single fasting glucose (FG), or long-term type 2 diabetes mellitus (T2DM) and sepsis remains unclear. METHODS: Of the adults aged ≥20 years who were included in the National Health Screening Program (NHSP) in 2009, 40% were randomly sampled. After excluding patients with type 1 diabetes mellitus, with missing information, and who were diagnosed with sepsis during the wash-out (betwe

EpidemiologyMedicine
10
논문|인용수 6·2023
Differences of clinical characteristics and outcome in proven invasive Trichosporon infections caused by asahii and non‐asahii species
Eun Hwa Lee, Min Hyuk Choi, Kyoung Hwa Lee, Young Goo Song, Sang Hoon Han
SJR Q1MycosesOA

BACKGROUND: Trichosporon is an emerging yeast that causes invasive infections in immunocompromised patients experiencing prolonged hospitalisation, indwelling venous catheters and neutropenia. METHODS: This retrospective observational cohort study analysed invasive Trichosporon infections (ITIs) occurring between January 2005 and December 2022 at three tertiary hospitals and compared the clinical characteristics and prognostic factors of ITIs caused by Trichosporon asahii and non-T. asahii spp.

Infectious DiseasesMedicine
11
논문|인용수 4·2024
The Relation Between Cigarette Smoking and Development of Sepsis: A 10-Year Follow-Up Study of Four Million Adults from the National Health Screening Program
Eun Hwa Lee, Kyoung Hwa Lee, Kyu‐na Lee, Yebin Park, Kyung Do Han, Sang Hoon Han
SJR Q2Journal of Epidemiology and Global HealthOA

BACKGROUND: Sepsis remains a growing global health concern with soaring mortality and no direct anti-sepsis drug. Although smoking has distinct deleterious effects on chronic inflammatory illnesses and can impair immune function, a comprehensive analysis of the connection between sepsis and smoking is lacking. METHODS: This large-scale longitudinal cohort study retrospectively assessed adults aged ≥ 20 years who underwent national health checkups under the Korean National Health Insurance Servic

EpidemiologyMedicine
12
논문|인용수 4·2010
Development of Key Indicators for Nurses Performance Evaluation and Estimation of Their Weights for Management by Objectives
Eun Hwa Lee, Sung Hee Ahn
SJR Q2Journal of Korean Academy of Nursing

PEKIs and their weights can be utilized for impartial evaluation and MBO for hospital nurses. Further research to verify PEKIs would lead to successful implementation of MBO.

Leadership and ManagementNursing
13
preprint|인용수 3·2022
Clinical and microbiological characteristics of and risk factors for bloodstream infections among patients with extracorporeal membrane oxygenation: A single-center retrospective cohort study
Eun Hwa Lee, Ki Hyun Lee, Se Ju Lee, Jin Nam Kim, Yae Jee Baek, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon‐Sup Yeom, Young Goo Song, Jung Ho Kim
Research SquareOA

Abstract Background Extracorporeal membrane oxygenation (ECMO) provides hemodynamic and oxygenation support to critically ill patients. Due to multiple catheter cannulations, patients on ECMO are vulnerable to bloodstream infections (BSIs). We aimed to investigate the incidence, clinical characteristics, risk factors, and microorganisms associated with BSIs during ECMO. Methods This single-center retrospective cohort study was conducted between January 2015 and May 2021. Patients aged 18 years o

Biomedical EngineeringEngineering
14
논문|인용수 3·2022
Low Dehydroepiandrosterone (DHEA) Level Is Associated with Poor Immunologic Response among People Living with HIV/AIDS
Eun Hwa Lee, Ki Hyun Lee, Se Ju Lee, Jin Nam Kim, Jung Ho Kim, Jin Young Ahn, Nam Su Ku, Jun Yong Choi, Joon‐Sup Yeom, Su Jin Jeong
SJR Q1Journal of Clinical MedicineOA

Dehydroepiandrosterone (DHEA) is an adrenal steroid converted to potent androgens. This study aimed to discover the association between serum DHEA levels and immunologic response in people with HIV/AIDS (PLWHA). We enrolled patients aged ≥ 18 years who were treated with combination antiretroviral therapy (cART). We measured CD4+ and CD8+ T-cell counts, HIV-RNA titres, and serum DHEA levels. We assigned each patient to a good- or poor-responder group depending on their CD4+ T-cell counts at study

Infectious DiseasesMedicine
15
논문|인용수 3·2023
Pentraxin 3 as an Immune Recovery Marker in HIV Infection After Combination Antiretroviral Therapy
Eun Hwa Lee, Jung Ah Lee, Chang Hyup Kim, Ki Hyun Lee, Jin Nam Kim, Jung Ho Kim, Jin Young Ahn, Nam Su Ku, Jun Yong Choi, Joon‐Sup Yeom, Su Jin Jeong
SJR Q3AIDS Research and Human Retroviruses

Human immunodeficiency virus (HIV) infection causes chronic inflammation in affected individuals. Chronic inflammation may hinder immunological recovery. Treatment with combination antiretroviral therapy (cART) is insufficient to reduce inflammation. Pentraxin 3 (PTX3) is an inflammatory marker associated with cardiovascular disease, malignancy, and acute infection. This study evaluated the usefulness of serum PTX3 levels in measuring inflammation levels, which may be associated with the probabi

ImmunologyImmunology and Microbiology

대표 연구 분야

EpidemiologyInfectious DiseasesBiomedical EngineeringMolecular BiologyCognitive NeuroscienceToxicology

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