김은주 교수

Obesity can be caused by microbes producing metabolites; it is thus important to determine the correlation between gut microbes and metabolites. This study aimed to identify gut microbiota-metabolomic signatures that change with a high-fat diet and understand the underlying mechanisms. To investigate the profiles of the gut microbiota and metabolites that changed after a 60% fat diet for 8 weeks, 16S rRNA gene amplicon sequencing and gas chromatography-mass spectrometry (GC-MS)-based metabolomic

Two classifiers -- Support Vector Machine (SVM) and Conditional Random Fields (CRFs) are applied here for the recognition of biomedical named entities. According to their different characteristics, the results of two classifiers are merged to achieve better performance. We propose an automatic corpus expansion method for SVM and CRF to overcome the shortage of the annotated training data. In addition, we incorporate a keyword-based post-processing step to deal with the remaining problems such as

BACKGROUND: Age and breed are considered the greatest risk factors for disease prevalence and mortality in companion dogs. Understanding the prevalence of diseases, in relation to age and breed, would support appropriate guidance for future health care strategies and provide useful information for the early diagnosis of diseases. The purpose of this study was to investigate the major medical causes for dogs visiting primary-care veterinary clinics in the Republic of Korea, stratified by age and

The objective of this study was to evaluate anti-obesity effects of kimchi microbial community (KMC) on obesity and gut microbiota using a high fat diet-induced mouse model compared to effects of a single strain. Administration of KMC decreased body weight, adipose tissue, and liver weight gains. Relative content of Muribaculaceae in the gut of the KMC-treated group was higher than that in the high-fat diet (HFD) group whereas relative contents of Akkermansiaceae, Coriobacteriaceae, and Erysipel

The objective of this study was to examine the anti-colitis activity of Jakyakgamcho-tang (JGT) in dextran sulfate sodium (DSS)-induced colitis and explore changes of the gut microbial community using 16S rRNA amplicon sequencing and metabolomics approaches. It was found that treatment with JGT or 5-aminosalicylic acid (5-ASA) alleviated the severity of colitis symptoms by suppressing inflammatory cytokine levels of IL-6, IL-12, and IFN-γ. The non-metric multidimensional scaling analysis of gut

Careful cleaning and disinfection of pigpens is essential to prevent disease spread and avoid the resultant economic losses. Hygiene in pigpens is generally evaluated by visual monitoring supplemented with bacteriological monitoring, which includes counting the total aerobic bacteria (TAB) and/or fecal indicator bacteria (FIB). However, these methods present drawbacks such as time and labor requirements. As adenosine triphosphate (ATP) is ubiquitous in all living organisms including microorganis

Eun-Ju Kim, Jae-Seong Kim, Seong-Eun Park, Seung-Ho Seo, Kwang-Moon Cho, Sun Jae Mee-Hyun Lee, Jae-Hong Kim, and Hong-Seok Son<br /><br />These authors contributed equally to this work.. J. Microbiol. Biotechnol. 2023;33:1-9. https://doi.org/10.4014/jmb.2305.05009

Many previous biological event-extraction systems were based on hand-crafted rules which were specifically tuned to a specific biological application domain. But manually constructing and tuning the rules are time-consuming processes and make the systems less portable. So supervised machine-learning methods were developed to generate the extraction rules automatically, but accepting the trade-off between precision and recall (high recall with low precision, and vice versa) is a barrier to improv

Myxomatous mitral valve disease (MMVD) is the most common cardiovascular disorder in dogs with a high prevalence, accounting for approximately 75% of all canine heart disease cases. MMVD is a complex disease and shows variable progression from mild valve leakage to severe regurgitation, potentially leading to heart failure. However, the molecular mechanisms and age-related changes that govern disease progression, especially at the early stage (B1) before the development of discernable clinical s

The purpose of this study was to establish reference ophthalmic findings in the common kestrel (Falco tinnunculus). Twenty healthy adult kestrels were included in this study. Ophthalmic examinations included slit lamp biomicroscopy, fundus exam, Schirmer tear test, conjunctival bacterial culture and isolation, corneal touch threshold, tonometry, and corneal diameter measurement. Mean tear production was 7.4 ± 3.27 mm/min, and mean intraocular pressure measured via applanation tonometry was 10.5

Background . Age and breed are considered the greatest risk factors for disease incidence and mortality in companion dogs. Understanding the incidence of diseases, in relation to age and breed, would support appropriate guidance for future health care strategies and provide useful information for the early diagnosis of diseases. The purpose of this study was to investigate the major medical causes for dogs visiting primary-care veterinary clinics in the Republic of Korea, stratified by age and b

In wireless sensor networks, an energy efficient data gathering scheme is one of core technologies to process a query. The cluster-based data gathering methods minimize the energy consumption of sensor nodes by maximizing the efficiency of data aggregation. However, since the existing clustering methods consider only uniform network environments, they are not suitable for the real world applications that sensor nodes can be distributed unevenly. To solve such a problem, we propose a balanced mul

Blood group determination in dogs is an important factor in transfusion medicine to minimize immediate or delayed adverse reactions after red blood cells transfusion in small animal clinics. Dog erythrocyte antigen (DEA) 1 is the most important blood type due to its high degree of antigenicity causing acute transfusion adverse reactions. The aim of this study was to investigate the prevalence of DEA 1 in various dog breeds in Korea. As a result of testing 592 blood samples from more than 35 dog