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PURPOSE: To investigate changes of inner retinal layers and optic nerve head (ONH) in patients with dry age-related macular degeneration (AMD) and demonstrate the pattern of these changes. METHODS: A total of 76 eyes classified as having dry AMD and 76 control eyes were included. Ophthalmologic evaluations included best-corrected visual acuity (BCVA) assessment, spectral-domain optical coherence tomography (SD-OCT), and Humphrey visual field (VF) test. The drusen area and volume were determined

Intraocular foreign bodies (IOFBs) are critical ophthalmic emergencies that require urgent diagnosis and treatment to prevent blindness or globe loss. This study aimed to examine the various clinical presentations of IOFBs, determine the prognostic factors for final visual outcomes, establish diagnostic protocols, and update treatment strategies for patients with IOFBs. We retrospectively reviewed patients with IOFBs between 2005 and 2019. The mean age of the patients was 46.7 years, and the mos

SFCT in eyes with RVO was significantly greater than it was in normal contralateral eyes. After Ozurdex injection, SFCT decreased significantly. Improvement in visual acuity was correlated with the decrease in SFCT after Ozurdex injection.

These results suggested that the RC might be a better choice for people who concern about surgical pain and early hospital discharge. Since there were no differences in postoperative health status between the 2 groups, health care providers as an advocate can provide more reliable information to their patients.

Silicone oil (SO) is widely used as a long-term intravitreal tamponading agent for rhegmatogenous retinal detachment (RRD) repair. This study investigated the structural changes of the foveal microvasculature using optical coherence tomography angiography (OCTA) in patients with RRD treated with vitrectomy and SO tamponade. Thirty-eight patients with unilateral RRD who were treated with vitrectomy and SO tamponade and were followed up for ≥3 months after SO removal were included. En face OCTA im

BACKGROUND: Endoplasmic reticulum (ER) stress induced by urinary albumin plays an important role in tubulointerstitial injury. We have shown that albumin-induced ER stress is regulated through reactive oxygen species (ROS)-c-Src kinase-mTOR signaling pathways. We postulated that peroxisome proliferator-activated receptor-γ (PPAR-γ) might also act as an upstream signaling molecule between c-Src kinase and mTOR. It has been suggested that AMP-activated protein kinase (AMPK) is involved in attenuat

Changes in glucose metabolism during diabetes are linked to an increased risk for the development of cancer. Increased activity of aldose reductase, the rate-limiting polyol pathway enzyme that converts glucose into sorbitol, mediates pathologies associated with diabetes and is thought to be involved in increased resistance to chemotherapeutic drugs. Thus, increased intracellular sorbitol levels may serve a protective function in cancer cells. In these studies we determined whether an inhibitor

We analyse the positive solutions to classes of p -Laplacian systems with Dirichlet boundary conditions, in particular, when the reaction terms tend to −∞ at the origin and satisfy a combined sublinear condition at ∞. We use the method of sub- and supersolutions to establish our results.

In Brief Purpose: To investigate morphologic characteristics of retinal arterial macroaneurysm (RAM) and its regression pattern using spectral-domain optical coherence tomography. Methods: This observational case series included six eyes of six patients with RAM. All patients had undergone repeated comprehensive ophthalmologic examination, including measurement of best-corrected visual acuity, slit-lamp biomicroscopy, indirect fundus examination, fundus photography, fluorescein angiography, and

We study positive radial solutions to the problem \begin{equation} \label{maineqn1} \begin{cases} -\Delta u = \lambda K(\left|x \right|) f(u) \quad & x \in \Omega, \\ \hskip 15pt u = 0 & \mbox {if } \left|x \right| = r_0, \\ \hskip 15pt u \rightarrow0 & \mbox{as } \left|x \right|\rightarrow \infty , \end{cases} \end{equation} where $\lambda$ is a positive parameter, $\Delta u=\mbox{div} \big(\nabla u\big)$ is the Laplacian of $u$, $\Omega=\{x\in\ \mathbb{R} ^{n},n>2 : \left|x \right|>r_0\}$ is a