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STUDY OBJECTIVES: The objective of this study was to examine the associations between the temporal and severity characteristics of sleep disturbance and subsequent depression in community-dwelling older adults. DESIGN: A prospective cohort study with assessment of sleep disturbance and depression at baseline and across 2 years of follow-up. SETTING: Three urban communities in the United States. PARTICIPANTS: Community-dwelling older adults in whom prior depression (n = 145), current depression (

Despite research into the development of digital cognitive behavioral therapy for insomnia (dCBT-I), research into the outcomes of dCBT-I on insomnia and the associated clinical conditions of depression and anxiety have been limited. The PubMed, PsycINFO (Ovid), Embase, and Cochrane databases were searched for randomized controlled trials (RCTs) on adult patients with insomnia also having reported measures of depressive or anxiety symptoms. In total, 2504 articles were identified after duplicate

Using proton magnetic resonance spectroscopy and magnetic resonance imaging, we investigated concentrations of various brain metabolites, including glutamate, and measured brain volumes and neuropsychological performances in 13 recently abstinent young alcoholic men compared with 18 controls. No differences were found in volumetric variables between groups (intracranial volume, white matter, grey matter, anterior cingulate, insula, hippocampus, and amygdala). For the anterior cingulate, choline

Interstitial lung disease in children (chILD) is a group of disorders characterized by lung inflammation and interstitial fibrosis. In the past recent years, we noted an outbreak of child in Korea, which is possibly associated with inhalation toxicity. Here, we report a series of cases involving toxic inhalational injury-associated chILD with bronchiolitis obliterans pattern in Korean children. This study included 16 pediatric patients confirmed by lung biopsy and chest computed tomography, betw

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTotal Synthesis of Pamamycin-607Eun Lee, Jeong, Eun Joo Kang, Lee Taek Sung, and Sung Kil HongView Author Information School of Chemistry and Molecular Engineering Seoul National University, Seoul 151-747, Korea Cite this: J. Am. Chem. Soc. 2001, 123, 41, 10131–10132Publication Date (Web):September 20, 2001Publication History Received24 May 2001Published online20 September 2001Published inissue 1 October 2001https://pubs.acs.org/doi/10.1021/ja016

OBJECTIVE: To investigate the risk of incident dementia according to fasting glucose levels and presence of comorbidities. RESEARCH DESIGN AND METHODS: Using a health insurance claims database and the results of biennial health examinations in South Korea, we selected 8,400,950 subjects aged ≥40 years who underwent health examinations in 2009-2010. We followed them until 2016. Subjects' baseline characteristics were categorized by presence of diabetes (yes/no) and glycemic status as normoglycemi

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT8-endo-Cyclization of (alkoxycarbonyl)methyl radicals generated from bromoacetatesEun Lee, Cheol Hwan Yoon, and Tae Hee LeeCite this: J. Am. Chem. Soc. 1992, 114, 27, 10981–10983Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/ja00053a056https://doi.org/10.1021/ja00053a056research-articleACS PublicationsRequest reuse permissionsArticle Views423Altmet

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxyanion Orientation in Anionic Oxy-Cope RearrangementsEun Lee, Yong Rok Lee, Bongjin Moon, Ohyun Kwon, Mi Seong Shim, and Jae Sook YunCite this: J. Org. Chem. 1994, 59, 6, 1444–1456Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/jo00085a037https://doi.org/10.1021/jo00085a037research-articleACS PublicationsRequest reuse permissionsArticle Views1236Altmetr

This study's aim was to investigate coping strategies and their relationship to symptoms in people at ultra high risk (UHR) for psychosis compared with recent-onset schizophrenia (SPR) and healthy controls. Thirty-three UHR participants, 22 SPR patients, and 33 healthy controls completed the Ways of Coping Questionnaire and other clinical measures. People at UHR for psychosis showed significantly more reliance on tension-reduction and less reliance on problem-focused coping than healthy controls