이응석 교수
Eung-seok Lee
고려대학교 의학과 · 생화학·유전·분자생물학
연구실 소개
이응석 교수의 연구실은 암 치료를 위한 새로운 타겟 기반 약물 개발에 초점을 맞추고 있으며, 특히 탑oisomerase IIα를 표적으로 하는 항암제의 구조-활성 관계를 체계적으로 탐색하고 있습니다. 또한, 염증 및 암 치료에 응용 가능한 이중 작용 억제제(예: COX/5-LOX 억제제)의 개발과 함께, 암 전이의 조기 진단을 위한 면역염색 기반 기술도 함께 연구하고 있습니다. 특히, 낮은 농도에서 높은 선택성과 효과를 보이는 신소재 약물 후보 물질의 설계에 주력하고 있습니다.
항암제 개발탑oisomerase IIα이중 작용 억제제암 전이 진단신약 설계
연구 현황
논문 수
140
총 인용 수
3,441
최근 5년 논문
16
주요 분야
생화학·유전·분자생물학
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
5개년 연도별 논문 게재 수
16총합
2019
2020
2021
2022
2023
5개년 연도별 피인용 수
124총합
20192020202120222023
주요 논문
151
논문|인용수 139·2007
Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activitiesJong‐Keun Son, Longxuan Zhao, Arjun Basnet, Pritam Thapa, Radha Karki, Younghwa Na, Yurngdong Jahng, Tae Cheon Jeong, Byeong‐Seon Jeong, Chong-Soon Lee, Eung-Seok Lee
SJR Q1European Journal of Medicinal Chemistry
Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
논문|인용수 133·2007
2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationshipArjun Basnet, Pritam Thapa, Radha Karki, Younghwa Na, Yurngdong Jahng, Byeong‐Seon Jeong, Tae Cheon Jeong, Chong-Soon Lee, Eung-Seok Lee
SJR Q2Bioorganic & Medicinal Chemistry
Molecular BiologyBiochemistry, Genetics and Molecular Biology
3
논문|인용수 106·2001
Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-Terpyridine derivativesLongxuan Zhao, Tae Sung Kim, Soohyun Ahn, Taehyung Kim, Eun‐Kyung Kim, Won‐Jea Cho, Heesung Choi, Chong-Soon Lee, Jung‐Ae Kim, Tae Cheon Jeong, Ching-jer Chang, Eung-Seok Lee
SJR Q2Bioorganic & Medicinal Chemistry Letters
Molecular BiologyBiochemistry, Genetics and Molecular Biology
4
논문|인용수 96·2004
Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activitiesYurngdong Jahng, Longxuan Zhao, Yoon‐Soo Moon, Arjun Basnet, Eun‐Kyung Kim, Hyeun Wook Chang, Hye Kyung Ju, Tae Cheon Jeong, Eung-Seok Lee
SJR Q2Bioorganic & Medicinal Chemistry LettersOA
PharmacologyMedicine
5
논문|인용수 95·2004
Synthesis, topoisomerase I inhibition and structure–activity relationship study of 2,4,6-trisubstituted pyridine derivativesLongxuan Zhao, Yoon‐Soo Moon, Arjun Basnet, Eun‐Kyung Kim, Yurngdong Jahng, Jae Gyu Park, Tae Cheon Jeong, Won‐Jea Cho, Sang‐Un Choi, Chong Ock Lee, Sun‐Young Lee, Chong-Soon Lee
SJR Q2Bioorganic & Medicinal Chemistry LettersOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
논문|인용수 92·2002
Prognostic relevance of immunohistochemically detected lymph node micrometastasis in patients with gastric carcinomaEung-Seok Lee, Yang‐Seok Chae, Insun Kim, Jongsang Choi, Bomwoo Yeom, Anthony S.‐Y. Leong
SJR Q1CancerOA
BACKGROUND: Micrometastases consisting of one to a few cells in lymph nodes resected during gastrectomy are difficult to identify using conventional hematoxylin and eosin (H&E) stains. It has been shown that immunostaining for cytokeratins is effective in detecting lymph node micrometastasis in a variety of human tumors, but only a few previous reports demonstrated its use in the treatment of patients with early and advanced gastric carcinoma, and those reports had conflicting results. METHODS:
Pulmonary and Respiratory MedicineMedicine
7
논문|인용수 90·2010
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridinesRadha Karki, Pritam Thapa, Mi Jeong Kang, Tae Cheon Jeong, Jung Min Nam, Hye-Lin Kim, Younghwa Na, Won‐Jea Cho, Youngjoo Kwon, Eung-Seok Lee
SJR Q2Bioorganic & Medicinal Chemistry
Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
논문|인용수 65·2004
Inhibition of Nitric Oxide and Tumor Necrosis Factor-.ALPHA. (TNF-.ALPHA.) Production by Propenone Compound through Blockade of Nuclear Factor (NF)-.KAPPA.B Activation in Cultured Murine MacrophagesEung-Seok Lee, Hye Kyung Ju, Tae Churl Moon, Eunkyung Lee, Yurngdong Jahng, Sung Ho Lee, Jong Keun Son, Suk‐Hwan Baek, Hyeun Wook Chang
SJR Q2Biological and Pharmaceutical BulletinOA
Lipopolysaccharide (LPS)-stimulated macrophages produce large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS). This is an important mechanism in macrophage-induced septic shock and inflammation. In the present study, we tested a synthetic propenone compound, 1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) for its ability to inhibit the production of tumor necrosis factor-alpha (TNF-alpha) and an inducible enzyme, iNOS, in the LPS-stimulated murine macrophage-like cell line,
Molecular BiologyBiochemistry, Genetics and Molecular Biology
9
논문|인용수 58·2006
Synthesis, cytotoxicity and structure-activity relationship study of terpyridinesLongxuan Zhao, Jyoti Sherchan, Jung Ki Park, Yurngdong Jahng, Byeong‐Seon Jeong, Tae Cheon Jeong, Chong-Soon Lee, Eung-Seok Lee
SJR Q1Archives of Pharmacal Research
Molecular BiologyBiochemistry, Genetics and Molecular Biology
10
논문|인용수 56·2017
Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel diseaseTara Man Kadayat, Suhrid Banskota, Pallavi Gurung, Ganesh Bist, Til Bahadur Thapa Magar, Aarajana Shrestha, Jung‐Ae Kim, Eung-Seok Lee
SJR Q1European Journal of Medicinal Chemistry
PharmacologyMedicine
11
논문|인용수 48·2009
2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure–activity relationship, and docking studyArjun Basnet, Pritam Thapa, Radha Karki, Ho-Young Choi, Jae Hun Choi, Minho Yun, Byeong‐Seon Jeong, Yurngdong Jahng, Younghwa Na, Won‐Jea Cho, Youngjoo Kwon, Chong-Soon Lee
SJR Q2Bioorganic & Medicinal Chemistry Letters
Molecular BiologyBiochemistry, Genetics and Molecular Biology
12
논문|인용수 47·2003
Ginsenoside RB1 the anti-ulcer constituent from the head ofPanax ginsengChoon Sik Jeong, Jin Ee Hyun, Yeong Shik Kim, Eung-Seok Lee
SJR Q1Archives of Pharmacal Research
Molecular BiologyBiochemistry, Genetics and Molecular Biology
13
논문|인용수 41·2010
Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationshipPritam Thapa, Radha Karki, Ho-Young Choi, Jae Hun Choi, Minho Yun, Byeong‐Seon Jeong, Mi-Ja Jung, Jung Min Nam, Younghwa Na, Won‐Jea Cho, Youngjoo Kwon, Eung-Seok Lee
SJR Q2Bioorganic & Medicinal Chemistry
Molecular BiologyBiochemistry, Genetics and Molecular Biology
14
논문|인용수 32·2017
Inhibition of LPS-stimulated ROS production by fluorinated and hydroxylated chalcones in RAW 264.7 macrophages with structure-activity relationship studyGanesh Bist, Nirmala Tilija Pun, Til Bahadur Thapa Magar, Aarajana Shrestha, Hye Jin Oh, Amrita Khakurel, Pil‐Hoon Park, Eung-Seok Lee
SJR Q2Bioorganic & Medicinal Chemistry Letters
PharmacologyMedicine
15
논문|인용수 32·2017
Design, synthesis, and structure-activity relationship study of halogen containing 2-benzylidene-1-indanone derivatives for inhibition of LPS-stimulated ROS production in RAW 264.7 macrophagesAarajana Shrestha, Hye Jin Oh, Mi Jin Kim, Nirmala Tilija Pun, Til Bahadur Thapa Magar, Ganesh Bist, Hongseok Choi, Pil‐Hoon Park, Eung-Seok Lee
SJR Q1European Journal of Medicinal Chemistry
Organic ChemistryChemistry
대표 연구 분야
Molecular BiologyPharmacologyOrganic ChemistryOncologyEpidemiologyPulmonary and Respiratory Medicine
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