김근수 교수
Geun-soo Kim
연세대학교 신경외과 · 의학
연구실 소개
김근수 교수의 연구실은 척추디스크의 퇴행성 변화와 관련된 생물학적 메커니즘을 규명하고, 이를 바탕으로 척추 수술의 안정성과 치료 성과를 향상시키는 데 초점을 맞추고 있습니다. 특히 니코틴이 디스크 세포에 미치는 직접적 영향과 혈관 공급 감소 메커니즘, 그리고 척추 후방간접유합술(PLIF)에서의 뼈 성장 촉진 전략에 대한 연구를 진행하고 있습니다. 또한 임신 중 척추수술의 안전성과 경추디스크플라스티의 이환성 합병증인 이질성 뼈 형성(HO)의 유발 요인 분석 등 임상적 응용에 기여하는 연구를 지속하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15In the first experiment, the 21-gauge 3-puncture and the 18-gauge 1-puncture models produced the most consistent disc degeneration in the rabbit lumbar spine. When these 2 models were again studied in the second experiment, the 21-gauge 3-puncture technique was superior in producing disc degeneration over a shorter period of time.
In most spinal diseases, including HLD and tumors, prepartum surgical treatment can be safely performed maintaining pregnancy. For patients with progressive neurologic deficit at 34 to 36 weeks gestation or later, spine surgery should be performed following the induction of delivery or a cesarean section, or at the same time.
OBJECT: Systemic nicotine has been hypothesized to cause degeneration of the intervertebral disc which in turn decreases vascular supply to the disc through a cholinergic receptor-mediated process. Another possible mechanism may be through direct regulatory effects on disc cells. In this study, the authors tested the hypothesis that nicotine adversely affects nucleus pulposus cells by directly inhibiting proteoglycan synthesis and gene expression of type II collagen (Phase I study). They also as
STUDY DESIGN: Prospective clinical study. OBJECTIVE: To evaluate the factors that would predispose a patient to heterotopic ossification (HO) formation after cervical arthroplasty. SUMMARY OF BACKGROUND DATA: HO after arthroplasty is one of the complications of cervical total disk replacement (TDR). However, the predisposing factors and pathophysiology of HO have not been precisely described. MATERIALS AND METHODS: We prospectively enrolled and followed up 23 patients, who received single-level
All the intervertebral bone fusion after PLIF occurred inside the cages and in the posterior intervertebral space. We suggest the complete removal of discmaterial and deep insertion of the cages to create sufficient posterior intervertebral space for bone growth. PLIF using cages impacted with laminar bone chips is a useful method when considering the time required for surgery and the morbidity of the autograft donor sites.
3.
We report a significant improvement of an approximate method of including electron Coulomb distortion in electron-induced reactions at momentum transfers greater than the inverse of the size of the target nucleus. In particular, we have found a new parametrization for the elastic electron scattering phase shifts that works well at all electron energies greater than 300 MeV. As an illustration, we apply the improved approximation to the ${(e,e}^{\ensuremath{'}}p)$ reaction from medium and heavy n
STUDY DESIGN: Retrospective case analysis. OBJECTIVE: This study was conducted to investigate the course of ossification of the posterior longitudinal ligament (OPLL) progression after laminoplasty (LP) or laminectomy with posterior fixation (PF). SUMMARY OF BACKGROUND DATA: LP is now recognized as a standard technique for the treatment of cervical multisegment OPLL; however, PF is beneficial for patients with severe stenosis. In recent years, there has been increasing interest in mechanical str
OBJECTIVE: Orbotron training is a popular training method for fighter pilots because it replicates a high-acceleration environment with excessive G-force. The purpose of this study was to investigate the effects of 9 weeks of orbotron training on oxidative DNA damage and antioxidant capacity in humans during 3-dimensional space exercise. SUBJECTS AND METHODS: The subjects comprised 15 senior cadets from the Korea Air Force Academy who had no record of medical disorders and who participated in a
BACKGROUND: Many patients with cervical radiculopathy experience stenosis of the neural foramens due to cumulative osteophyte or uncovertebral joint hypertrophy. For cervical foraminal stenosis, complete uncinate process resection (UPR) is often conducted concurrently with anterior discectomy and fusion (ACDF). The aim of this study was to assess the clinical and radiological outcomes of ACDF with complete UPR versus ACDF without UPR. METHODS: In total, 105 patients who performed one-level ACDF
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