김국래 교수

Glycogen synthase kinase-3β (GSK3β) is a highly conserved kinase that functions as a key regulator of many cellularsignalling pathways. Unlike other kinases, GSK3β transduces signalling via inhibition by upstream kinases or factors. Inthe Wnt/β-catenin signalling pathway, the Wnt coreceptor LRP6/5 serves as a direct inhibitor of GSK3β when the PPPSPmotif in LRP6/5 is phosphorylated upon Wnt activation. We constructed a chimeric protein composed of the PPPSP motifand the mouse GSK3β to determine

G-protein-coupled receptors (GPCRs) are seven-transmembrane proteins that play important roles in signal transductionfrom the extracellular compartment to the cytoplasm. GPCR malfunction has been implicated in various diseases such ascancer, allergy, neuronal disease, rheumatism, and obesity. Because of the importance of GPCRs, GPCR-targeting drugsoccupy approximately 40% of the total drug market. Recently, three-dimensional structures of many GPCRs have beensuccessfully ascertained on the basis