박광우 교수
Gwang-Woo Park
연세대학교 방사선종양학과 · 물리·천문학
연구실 소개
박광우 교수의 연구실은 방사선 옹호 치료 및 암 치료의 정밀도를 높이기 위한 기초 및 임상 연구를 중심으로 전개됩니다. 특히 이식 후 당뇨병(PTDM)의 발병 기전을 규명하고, 가슴 방사선 치료 시 심장과 폐에 미치는 영향을 최소화하기 위한 기술적 최적화(예: DIBH, 3D 프린팅 볼러스)에 주력하고 있습니다. 또한, 방사선 치료의 정확성과 안전성을 높이기 위한 영상 유도 치료, 동물 모델 개발, 실시간 선량 측정 기술 등 첨단 기반 기술을 융합한 연구를 진행하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15These results revealed that fasting and 2-hr plasma glucose levels, as well as the proinsulin/insulin ratio before transplantation, are both possible indicators of beta-cell dysfunction and may be predictors for the development of PTDM. Furthermore, beta-cell dysfunction, rather than insulin resistance, was proven to be the main factor for the pathogenesis of PTDM.
PURPOSE: We explored whether the deep inspiration breath hold (DIBH) technique using Abches during left-sided breast irradiation was effective for minimizing the amount of radiation to the heart and lung compared to free breathing (FB). MATERIALS AND METHODS: Between February and July 2012, a total of 25 patients with left-sided breast cancer underwent two computed tomography scans each with the DIBH using Abches and using FB after breast-conserving surgery. The scans were retrospectively replan
While atlas segmentation (AS) has proven to be a time-saving and promising method for radiation therapy contouring, optimal methods for its use have not been well-established. Therefore, we investigated the relationship between the size of the atlas patient population and the atlas segmentation auto contouring (AC) performance. A total of 110 patients’ head planning CT images were selected. The mandible and thyroid were selected for this study. The mandibles and thyroids of the patient populatio
The 3D-printed boluses were used during the radiation therapy of the chest wall in six patients with breast cancer after modified radical mastectomy (MRM). We measured the in-vivo skin doses while both conventional and 3D-printed boluses were placed on the chest wall and compared the mean doses delivered to the ipsilateral lung and the heart. The homogeneity and conformity of the dose distribution in the chest wall for both types of boluses were also evaluated. The uniformity index on the chest
Given the tremendous potential of stereotactic body radiotherapy (SBRT), investigations of the underlying radiobiology associated with SBRT-induced normal tissue injury are of paramount importance. This study was designed to develop an animal model that simulates centrally and peripherally located clinical SBRT-induced lung injuries. A 90-Gy irradiation dose was focally delivered to the central and peripheral areas of the left mouse lung with an image-guided small-animal irradiation system. At 1
IORT as a boost was well-tolerated among Korean women without severe acute complication. In vivo dosimetry with OSLD can help ensure safe delivery of IORT as a boost.
A semiempirical method based on the averaging effect of the sensitive volumes of different air-filled ionization chambers (ICs) was employed to approximate the correction factors for beam quality produced from the difference in the sizes of the reference field and small fields.We measured the output factors using several cylindrical ICs and calculated the correction factors using a mathematical method similar to deconvolution; in the method, we modeled the variable and inhomogeneous energy fluen
본 논문은 슐라이어마허의 그리스도교 윤리학적 관점을 바탕으로 애국심과 세계시민주의 간의 관계에 대한 그리스도교적인 이해를 탐구한다. 슐라이어마허에 따르면 민족 공동체는 인류애와 연결되는 최고선이 개진되는 윤리적 과정에서 나타난 공동체이며, 애국심은 민족 공동체를 통하여 선제적으로 형성된 인류애이다. 종교는 전체에 대한 수동성과 수용을 바탕으로 모두가 각자의 개성을 상호존중하고 서로 사랑하는 진정한 세계시민주의의 이념을 드러내는데, 그리스도교는 이를 예수 그리스도를 통해 계시된 하느님의 영의 역사와 거기에 근거한 형제사랑으로 나타낸다. 슐라이어마허의 그리스도교적인 이해에 따르면 하느님의 영의 역사에 기초한 그리스도교적 형제사랑인 세계시민주의는 애국심의 이념이고, 애국심은 그러한 세계시민주의가 민족 공동체 안에서 구체적으로 형성된 것이다. 이제 그리스도인은 전체로서의 하느님의 영의 역사 가운데 모든 민족이 고유한 민족성으로 그 역사를 형성하며 자유롭고 평등하게 교류한다는 그리스도교적 문
Abstract Purpose In this study, we developed a simple but useful computer program, called TomoMQA, to offer an automated quality assurance for mega‐voltage computed tomography (MVCT) images generated via helical tomotherapy. Methods TomoMQA is written in MATLAB and contains three steps for analysis: (a) open the DICOM dataset folder generated via helical tomotherapy (i.e., TomoTherapy ® and Radixact™), (b) call the baseline data for the consistency test and click the “Analysis” button (or click
We investigated the volume averaging effect for air-filled cylindrical ionization chambers to determine the correction factors in a small photon field for a given chamber. We measured output factors with several cylindrical ionization chambers, and by using a mathematical method similar to deconvolution, we modeled the non-constant and inhomogeneous exposure function in the cavity of the chamber. The parameters in the exposure function and the correction factors were determined by solving a syst
Purpose: The purpose of this study is to compare the dosimetry of electron beam (EB) plans and three-dimensional helical tomotherapy (3DHT) plans for the patients with left-sided breast cancer, who underwent breast conserving surgery. Materials and Methods: We selected total of 15 patients based on the location of tumor, as following subsite: subareolar, upper outer, upper inner, lower lateral, and lower medial quadrants. The clinical target volume (CTV) was defined as the area of architectural
A 3D-printed applicator for intraoperative radiation therapy (IORT) using the INTRABEAM system has been introduced, designed to protect normal tissue, expand indications, and assess its effectiveness in various intraoperative settings. The study involved designing and creating inclined applicators at 0° and 45° angles, which were capable of producing flattened and unflattened beams and shielding non-target areas from radiation. The applicator was evaluated based on dose uniformity, percentage de
OBJECTIVE: This study aims to evaluate the feasibility of radiation treatment planning using a commercial treatment planning system (TPS) for small fixed-size electron cone electron applicators not natively supported by the TPS. METHODS: Dosimetric characteristics, including beam profiles and output factors (OFs), were compared between a 6 MeV electron beam collimated by a small fixed-size electron cone applicator and a cerrobend cutout-based general applicator. Measurements were performed using
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