김규리 교수

This report describes a simple method to prepare water-soluble chitosan derivative by conjugation of an enediol group, catechol. Chitosan functionalized with a catechol-containing compound, 3,4-dihydroxyhydrocinnamic acid, by a carbodiimide coupling method resulted in chitosan-catechol conjugates. This one-step chemical modification of high-molecular-weight chitosan (approximately 100 kDa) dramatically increased the water solubility of the chitosan derivative to 60 mg mL^-1 at pH 7.0.

Hyper-activated melanocytes are the major cause of skin hyper-pigmentary disorders, such as freckles and melasma. Increasing efforts have been made to search for materials with depigmenting activity to develop functional cosmetics. As a result, numerous materials have been reported to have depigmenting activity but some of them are known to cause unwanted side effects. Consequently, anti-pigmentary natural compounds without concern of toxicity are in great demand. Virtually all sorts of natural

With the rapid growth of wireless communication devices, the influences of electromagnetic fields (EMF) on human health are gathering increasing attention. Since the skin is the largest organ of the body and is located at the outermost layer, it is considered a major target for the health effects of EMF. Skin pigmentation represents one of the most frequent symptoms caused by various non-ionizing radiations, including ultraviolet radiation, blue light, infrared, and extremely low frequency (ELF)

There is a great need for improved diagnostic and prognostic accuracy of potential cardiac toxicity in drug development. This study reports the evaluation of several commercially available biomarker kits by 3 institutions (SRI, Eli Lilly, and Pfizer) for the discrimination between myocardial degeneration/necrosis and cardiac hypertrophy as well as the assessment of the interlaboratory and interplatform variation in results. Serum concentrations of natriuretic peptides (N-terminal pro-atrial natr

Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the murine melanoma cell line, B16F10, and human melanoma cell line, MNT-1, as well as a pigmented 3D-human skin model. (-)-4-Hydroxysattabacin treatment decreased melanin contents in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-stimulated B16F1

Recently, the impacts of 5G electromagnetic radiation (EMR) with 28 GHz on human health have been attracting public attention with the advent of 5G wireless communication. Here, we report that 5G (28 GHz) EMR can attenuate the skin pigmentation in murine melanoma cells (B16F10) and a 3D pigmented human epidermis model (Melanoderm™). B16 cells were exposed to 5G (28 GHz) with or without α-MSH for 4 h per day. Interestingly, 5G attenuated α-MSH-induced melanin synthesis. Fontana–Masson staining co

This study demonstrates that acremonidin E, a bioactive metabolite derived from a fungal endophyte of <i>P. ginseng,</i> can inhibit melanin synthesis by downregulating tyrosinase, illuminating the potential utility of microorganisms associated with <i>P. ginseng</i> for cosmetic ingredients.

Objectives: Undergraduates entering society and family members around them significantly in terms of their knowledge, attitudes, and behavior related to oral health. Methods: We conducted a self-assessment survey of 634 undergraduates at three universities from October 21st to 30th of 2008. The collected data were converted into scores and analyzed with the statistical program, SPSS. Results: 1. We had 30.2% male students and 56.9% of all surveyed had received oral health education. 2. The level

Ginseng has been utilized for centuries in both the medicinal and cosmetic realms. Recent studies have actively investigated the biological activity of ginseng berry and its constituents. (+)-Syringaresinol [(+)-SYR], an active component of ginseng berry, has been demonstrated to have beneficial effects on the skin, but its potential impact on skin pigmentation has not been fully explored. Here, the antioxidant and anti-pigmentary activity of (+)-SYR were evaluated in B16F10 murine melanoma cell

This paper examines WHO's involvement in South Korea within the context of the changing organization of public health infrastructure in Korea during the years spanning from the end of the Japanese occupation, through the periods of American military occupation and the Korean War, and to the early years of the Park Chung Hee regime in the early 1960s, in order to demonstrate how tuberculosis came to be addressed as a public health problem. WHO launched several survey missions and relief efforts b

본 연구는 이산화염소수 처리가 식품에서의 잔류농약 제거에 효과가 있는지 조사하기 위해서 수행되었다. 10, 50, 100 ppm 이산화염소수로 채소류에 흔히 쓰이는 농약인 chlrpyrifos, diazinon, metalaxyl을 처리하여 GC를 이용하여 농약의 분해율을 측정하였다. 상기 세 가지 농약 성분은 이산화염소수 처리 농도뿐만 아니라 처리시간에 비례하여 분해되었으며 특히 100 ppm 이산화염소수 처리가 가장 효과적이었다. 또한, 인위적으로 농약을 오염시킨 상추를 증류수, 100 ppm 이산화염소수에 각각 침지하여 농약의 제거율을 비교해 보았을 때, 100 ppm 이산화염소수에 10분 동안 침지하였을 때가 가장 효과가 좋았다. 본 연구 결과, 이산화염소수 처리는 신선농산물에서의 잔류농약을 제거하기 위한 세척수로 이용될 수 있을 것으로 판단된다.

Following two gas explosions in 1995 that resulted from poor management of information on underground pipes, the Republic of Korea accelerated its efforts to update and integrate spatial data, such as underground maps. The Ministry of Construction and Transportation (which became the Ministry of Land, Infrastructure and Transport in 2013) led the integration initiative, but the ministry faced a lack of cooperation from counterpart ministries and agencies. It was often at a stalemate with its mai