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이해원 교수

Hae Won Lee

서울대학교 내과 · 의학

연구실 소개

이 교수의 연구실은 간세포생식성암(HCC)의 이식 기준 확장과 생존율 향상을 위한 임상적 연구에 중점을 두고 있습니다. 특히 밀란 기준을 초과하는 만성 간질환 환자에게서도 이식으로 유의미한 결과를 얻을 수 있는 생물학적 특성과 예후 요인을 규명하고 있으며, 생존율, 재발 위험, 기증자 및 수혜자 선별 기준의 최적화를 위한 다기관 임상 연구를 지속하고 있습니다. 또한 간 이식 후 합병증인 간내 담도협착 및 간부전성 폐질환 등에 대한 치료 전략 개발에도 기여하고 있습니다.

간세포생식성암이식 기준 확장생존율다기관 임상연구이식 후 합병증

연구 현황

논문 수
187
총 인용 수
2,495
최근 5년 논문
65
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
65총합
2021
2022
2023
2024
2025
5개년 연도별 피인용 수
302총합
20212022202320242025

주요 논문

15
1
논문|인용수 114·2018
A prospective randomized study comparing radiofrequency ablation and hepatic resection for hepatocellular carcinoma
Hae Won Lee, Jeong Min Lee, Jung‐Hwan Yoon, Yoon Jun Kim, Joong‐Won Park, Sang‐Jae Park, Seong Hoon Kim, Nam‐Joon Yi, Kyung‐Suk Suh
SJR Q2Annals of Surgical Treatment and ResearchOA

HR was significantly superior to RFA in terms of disease-free survival; however, the overall survival was excellent in both groups.

HepatologyMedicine
2
논문|인용수 83·2007
Classification and Prognosis of Intrahepatic Biliary Stricture After Liver Transplantation
Hae Won Lee, Kyung‐Suk Suh, Woo Young Shin, Eung‐Ho Cho, Nam‐Joon Yi, Jeong Min Lee, Joon Koo Han, Kuhn Uk Lee
SJR Q1Liver Transplantation

Intrahepatic biliary stricture (IHBS) after liver transplantation (LT) may develop in patients with hepatic artery thrombosis, chronic rejection, or ABO incompatibility, as well as in patients with prolonged warm ischemia in non-heart-beating donor (NHBD) LT. However, the clinical course and methods of management have not been well defined for IHBSs to date. Thus, the purpose of this study was to provide a classification of post-LT IHBS and to investigate patient prognosis. Forty-four patients w

SurgeryMedicine
3
논문|인용수 51·2018
Patient Selection by Tumor Markers in Liver Transplantation for Advanced Hepatocellular Carcinoma
Hae Won Lee, Gi‐Won Song, Sung‐Gyu Lee, Jong Man Kim, Jae‐Won Joh, Dai Hoon Han, Soon Il Kim, Seong Hoon Kim, Dong‐Sik Kim, Jai Young Cho, Kyung‐Suk Suh
SJR Q1Liver TransplantationOA

Although far advanced hepatocellular carcinoma (HCC) is generally considered a contraindication for liver transplantation (LT), biologically favorable tumors among them could show acceptable results. However, it is still unclear which tumors can be treated with LT. Data were collected on adult patients who underwent LT for HCC beyond the Milan criteria in 8 Korean LT centers between January 2000 and June 2013. Far advanced HCC was defined as HCC with the largest tumor ≥ 10 cm, 10 or more tumor n

HepatologyMedicine
4
리뷰|인용수 32·2016
Liver transplantation for advanced hepatocellular carcinoma
Hae Won Lee, Kyung‐Suk Suh
SJR Q1Clinical and Molecular HepatologyOA

There has been ongoing debate that the Milan criteria may be too strict that a significant number of patients who could benefit from liver transplantation (LT) might have been excluded. Based on this idea, various studies have been conducted to further expand the Milan criteria and give more HCC patients a chance of cure. In deceased donor LT (DDLT) setting, expansion of the criteria is relatively tempered because the results of LT for HCC should be comparable to those of patients with non-malig

HepatologyMedicine
5
리뷰|인용수 23·2016
Expansion of the criteria for living donor liver transplantation for hepatocellular carcinoma
Hae Won Lee, Kyung‐Suk Suh
SJR Q2Current Opinion in Organ Transplantation

The overall chance of survival, and recipient/donor preferences as well as the risk of recurrence are considered in the LDLT setting. Therefore, the selection criteria for liver transplantation for HCC could benefit from expansion for LDLT.

HepatologyMedicine
6
논문|인용수 18·2008
Hypophosphatemia after live donor right hepatectomy
Hae Won Lee, Kyung‐Suk Suh, Joohyun Kim, Woo Young Shin, Eung-Ho Cho, Nam‐Joon Yi, Kuhn Uk Lee
SJR Q1Surgery
NephrologyMedicine
7
리뷰|인용수 13·2016
Advancements of liver transplantation for hepatocellular carcinoma in Korea
Hae Won Lee, Kyung‐Suk Suh
SJR Q2Japanese Journal of Clinical OncologyOA

The Milan criteria are still considered the gold standard for patient selection criteria for liver transplantation in patients with hepatocellular carcinoma. However, those criteria may be too strict and thus exclude a significant number of patients who could benefit from liver transplantation. Based on this notion, many expanded selection criteria have been suggested. In Asian countries, where there is a serious shortage of deceased donor organs, living donor liver transplantation accounts for

HepatologyMedicine
8
논문|인용수 13·2010
Pulmonary Artery Embolotherapy in a Patient with Type I Hepatopulmonary Syndrome after Liver Transplantation
Hae Won Lee, Kyung‐Suk Suh, Joohyun Kim, Woo Young Shin, Nam‐Joon Yi, Hwan Jun Jae, Jin Wook Chung, So Won Oh, Keon Wook Kang, Kuhn Uk Lee
SJR Q1Korean Journal of RadiologyOA

Although liver transplantation (LT) is the only effective treatment option for hepatopulmonary syndrome (HPS), the post-LT morbidity and mortality have been high for patients with severe HPS. We performed post-LT embolotherapy in a 10-year-old boy who had severe type I HPS preoperatively, but he failed to recover early from his hypoxemic symptoms after an LT. Multiple embolizations were then successfully performed on the major branches that formed the abnormal vascular structures. After the embo

HepatologyMedicine
9
논문|인용수 6·2014
Occurrence of Eggs and Larvae of Blackfin Flounder Glyptocephalus stelleri (Pleuronectidae, Pisces) off Wangdol-cho, East Sea
Hae Won Lee, Soo Jeong Lee, Jae Hyung Yang, Jae-Bong Lee, Hyung Kee, Jin‐Koo Kim
Korean Journal of Fisheries and Aquatic SciencesOA

We report the first identification of a spawning ground of the blackfin flounder Glyptocephlaus stelleri near the Wangdol-cho sea mountains, located in the southern East Sea. Eggs and larval fish of G. stelleri were collected during April and June, 2014, when an abundance of eggs was found in the southern area of Wangdol-cho. Our findings suggest that G. stelleri prefers to spawn in the vicinity of the off-shore sea mountains, where the temperature is between 10 and <TEX>$12^{\circ}C$</TEX> and

Global and Planetary ChangeEnvironmental Science
10
논문|인용수 6·2013
The Role of Major Donors in Health Aid to the Democratic People’s Republic of Korea
이해원, Deborah Y. Ahn, 최소영, 김영찬, 최현주, 박상민

We investigated the major trends in health aid financing in the Democratic People’s Republic of Korea (DPRK) by identifying the primary donor organizations and examining several data sources to track overall health aid trends. We collected gross disbursements from bilateral donor countries and international organizations toward the DPRK according to specific health sectors by using the Organization for Economic Cooperation and Development creditor reporting system database and the United Nations

11
논문|인용수 5·2024
A Study on the Improvement of CartoonGAN Image Quality for Nonlinear Edge Reinforcement using SRCNN Quality Enhancement Processing
Hae Won Lee, Seong Geon Bae
Asia-pacific Journal of Convergent Research InterchangeOA

With the recent development of image processing and deep learning technology, research and application in the fields of ultra-high-resolution image generation and cartoon-style conversion are expanding further.Among the ultra-resolution image generation models, the CartoonGAN model is specialized in generating cartoon-style images, but there are limitations in terms of resolution improvement.This study proposes an innovative method of additionally applying a Super-Resolution Convolutional Neural

MarketingBusiness, Management and Accounting
12
논문|인용수 4·2012
Liver Transplantation for Hepatitis C Virus-Related Liver Disease in Korea
Hae Won Lee, Kwang‐Woong Lee, Bong‐Wan Kim, Gi‐Won Song, Young Seok Han, Choon Hyuck David Kwon, Seong Hoon Kim, Gi Hong Choi, Jong Young Choi
Korean Journal of TransplantationOA

Hae Won Lee, M.D., Kwang-Woong Lee, M.D., Bong-Wan Kim, M.D., Gi-Won Song, M.D., Young Seok Han, M.D., Choon Hyuck David Kwon, M.D., Seong Hoon Kim, M.D., Gi Hong Choi, M.D. and Jong Young Choi, M.D.. J Korean Soc Transplant 2012;26:269-76. https://doi.org/10.4285/jkstn.2012.26.4.269

HepatologyMedicine
13
논문|인용수 3·2007
Preoperative lamivudine therapy in HBV DNA positive recipients: is it always necessary?
Hae Won Lee, Kyung‐Suk Suh, Nam‐Joon Yi, Sung Yang, Eung‐Ho Cho, Jai Young Cho, Choon Hyuck David Kwon, Yong Beom Cho, Kuhn Uk Lee
PubMed

BACKGROUND/AIMS: Long-term preoperative lamivudine therapy has been recommended for patients with positive HBV DNA to suppress HBV replication before liver transplantation. However, it is unclear whether preoperative lamivudine therapy is mandatory in HBV DNA positive patients to reliably prevent HBV recurrence or whether transplantation should be delayed to allow time for sufficient preoperative lamivudine therapy. METHODOLOGY: From January 2000 to January 2004, thirty-eight patients serum posi

EpidemiologyMedicine
14
논문|인용수 2·2021
Technical Tips in Laparoscopic Donor Right Hepatectomy in Living Donor Liver Transplantation
Hae Won Lee, Ho‐Seong Han, Jai Young Cho
SJR Q4Surgery Gastroenterology and OncologyOA

Although laparoscopic donor right hepatectomy (LDRH) is increasingly performed in adult living donor liver transplantation, most experiences have been reported from a limited number of major transplant centers. This is because LDRH requires high-level surgical skills and a guarantee of donor safety. Thus, despite its many advantages, this operation program should be performed with caution, especially in less experienced centers. Various surgical techniques and the know-how have been introduced b

SurgeryMedicine
15
논문|인용수 2·2021
Age and Growth Characteristic of Pacific Anchovy, Engraulis japonicus, in the Southern Waters of Korea Based on the Year Ring of Otolith and Collection Date
Hae Won Lee, Sun Do Hwang, Hee‐Yong Kim
Korean Journal of Ichthyology

멸치의 연령 및 성장특성을 분석하기 위해 2004년에 남해연안에서 채집된 개체들의 이석 506개를 분석하였으며, 윤문에 의해 결정된 연령과 채집시기를 기준으로 멸치의 월령을 추정하였다. 월령별 가랑이 체장을 이용하여 구한 성장 매개변수인 이론적 최대 체장은 132.9 mm, 성장계수는 0.1079/month였으며 체장이 0일 때의 이론적 연령은 1.0262월이었다. 이들 매개변수로 von Bertalanffy 체장성장식을 나타내면, L<sub>t</sub>=132.9(1- e<sup>-0.1079 (t-1.0262)</sup>)였다. 연륜과 채집시기를 통해 설정한 월령기준의 성장 매개변수 추정은 우리나라 멸치의 성장특성을 파악하기에 적절한 것으로 판단되었다.

Aquatic ScienceAgricultural and Biological Sciences

대표 연구 분야

HepatologySurgeryEpidemiologyGlobal and Planetary ChangePulmonary and Respiratory MedicineOncology

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