조한별 교수

Most tumors frequently undergo initial treatment with a chemotherapeutic agent but ultimately develop resistance, which limits the success of chemotherapies. As cisplatin exerts a high therapeutic effect in a variety of cancer types, it is often used in diverse strategies, such as neoadjuvant, adjuvant and combination chemotherapies. However, cisplatin resistance has often manifested regardless of cancer type, and it represents an unmet clinical need. Since we found that API5 expression was posi

Purpose: To determine the most powerful cancer antigen 125 (CA125)-related prognostic factor for advanced epithelial ovarian cancer (EOC) and to identify cut-off values that distinguish patients with a poor prognosis from those with a good prognosis. Materials and Methods: We included 223 patients who received staging laparotomy and were diagnosed with stage IIC–IV serous EOC. Cox regression analysis was used to determine the most significant prognostic factor among the following variables: seru

Clinical practice guidelines for gynecologic cancers have been developed by many organizations. Although these guidelines have much in common in terms of the practice of standard of care for uterine corpus cancer, practice guidelines that reflect the characteristics of patients and healthcare and insurance systems are needed for each country. The Korean Society of Gynecologic Oncology (KSGO) published the first edition of practice guidelines for gynecologic cancer treatment in late 2006; the sec

Purpose: To investigate chemosensitivity with an adenosine triphosphate-based chemotherapy response assay in patients with epithelial ovarian or peritoneal cancer according to tumor histology, grade, and disease status. Materials and Methods: One hundred specimens were collected during primary or secondary debulking from 67 patients with primary ovarian cancer, 24 patients with recurrent ovarian cancer, 5 patients with primary peritoneal cancer, and 4 patients with recurrent peritonealcancer; sa

=난소의 스테로이드세포종양은 전체 난소종양의 0.1% 이하를 차지하는 희귀한 질환으로, 보고된 바에 의하면 약 3.3% 내지 25%에서 무증상을 보인다. 우리나라에서 보고된 3 증례의 스테로이드세포종양은 모두 내분비학적 증상을 보였고 개복술을 통해 진단 및 치료하였다. 본 저널의 저자들은 내분비학적 증상이 없이 20주 정도 크기의 복부 종괴를 주소로 내원한 17세 여성에서, 초음파 유도하에 낭종을 흡입하고 복강경으로 스테로이드세포종양을 진단 및 치료하였기에 국내 문헌상 보고가 매우 드문 점과 그 희귀성에 비추어 문헌적 고찰과 함께 보고하는 바이다.

Purpose: We retrospectively investigated the diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography (PET) and PET/CT for cancer detection in asymptomatic health-check examinees. Materials and Methods: This study consisted of 5091 PET or PET/CT conducted as part of annual health examination at one hospital from March 1998 to February 2008. To find the incidence of cancers, medical records of the subjects were thoroughly reviewed for a follow-up period of one year. The patte

=저자들은 임신 중 급성 지방간 1예를 경험하였기에 임신 중 급성 지방간의 진단, 임상 경과, 생화학적 검사 소견의 변화, 합병증, 모성 및 태아의 결과를 보고하고자 한다. 31세 경산부가 임신 35주에 신물이 올라오는 증상을 주소로 내원하여 황달이 관찰되고 혈액 검사상 간 및 신장 기능부전, 파종성 혈관내 응고병증 소견을 보이며 초음파상 지방간 소견을 보여 임신 중 급성 지방간으로 진단한 후 응급 제왕 절개술을 시행하여 모성의 복수, 태변이 착색된 양수 과다를 볼 수 있었고 2330 g의 건강한 남아를 분만하였다. 분만 후 1일, 2일, 6일째 각각 핍뇨, 급성호흡곤란 증후군, 췌장염이 발생하였다. 집중치료 후 AST/ALT, 크레아티닌 및 섬유소원, PT/PTT, 혈소판과 같은 혈액응고인자는 분만 후 7-10일, 췌장염은 분만 후 24일에 회복되었다. 급성 호흡곤란 증후군을 위한 인공호흡기 치료는 분만 후 49일까지 지속되었으며, 분만 후 88일에 퇴원을 지시하였다. 증가된 총

=자궁 육종은 자궁의 중배엽에서 발생하는 드문 질환으로 자궁에서 발생하는 악성 종양의 2-6%에 불과하며 조직학적 아형으로 자궁 평활 근육종, 악성 혼합 밀러씨 종양, 자궁내막 간질성육종 등이 있다. 자궁내막 간질성육종은 자궁 육종의 7-15%를, 전체 여성 생식기 악성 종양의 약 0.2%를 차지하며, 핵분열상, 혈관침범여부에 따라 자궁내막 간질성 결절, 저등급 자궁내막 간질성육종 그리고 고등급 자궁내막 간질성육종의 세 가지 아형으로 구분된다.저등급 자궁내막 간질성육종은 고등급 자궁내막 간질성육종에 비해 임상적으로 좀 더 완만한 경과를 보이며 전이가 일어날 수 있으나 대부분 진행이 느리다.

Objective: To examine the correlation between cervical cytology and final histological results in patients who have undergone loop electrosurgical excision procedure (LEEP) with or without colposcopy-directed biopsy. Methods: A retrospective review was performed of 829 patients who underwent LEEP for abnormal cervical cytology at Gangnam Severance Hospital between January 2004 and December 2008. Patients were classified to three groups according to cervical cytology and also divided into two gro

Background: using a new heating-chilling process designed to yield L1 VLPs with high purity and homogeneity. Methods: The 9-valent vaccine formulation contained L1 VLPs for HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58. A double-blind, randomized clinical trial was conducted in which participants were assigned in a 1:1 ratio to receive either the investigation vaccine or a placebo consisting solely of aluminum phosphate (AP) gel, used as an adjuvant. A total of 41 healthy women aged 19-45 year

목적로봇을 이용한 자궁근종절제술을 복강경하 자궁근종절제술, 개복하 자궁근종절제술과 임상 양상 및 수술 후 경과에 대해 비교하여 보고자하였다. 연구방법2007년 1월부터 2011년 3월까지 자궁근종절제술을 시행 받은 환자를 수술방법에 따라 세 군으로 나누어 환자 및 근종의 특성, 수술 중및 수술 후 경과에 대해 후향적으로 의무기록을 분석하여 비교하였다. 결과총 206명의 환자 중 로봇을 이용한 자궁근종절제술을 시행한 환자(로봇수술 군)는 31명(15%), 복강경하 자궁근종절제술을 시행한 환자(복강경수술 군)는 70명(34%), 개복하 자궁근종절제술을 시행한 환자(개복수술 군)는 105명(51%)이었다. 로봇수술 군(164.3 ± 193.7 g)에서 제거된 근종의 무게는 개복수술 군(284.7 ± 265.6 g)과 비교했을 때에는 가벼웠지만 복강경수술 군(117.3 ± 132.7 g)에 비해서는더 무거웠다(P = 0.001). 평균 수술 중 출혈량은 개복수술 군, 로봇수술 군, 복강경수

Objective The main aim of this study was to evaluate cancer antigen 125 (CA125)/carcinoembryonic antigen (CEA) ratio (CCR),as a reliable marker to differentiate ovarian mucinous carcinoma from other epithelial ovarian carcinomas (EOCs),namely serous, clear cell, and endometrioid carcinomas. Methods Female patients suffering from different kinds of EOCs whom were subjected to elective surgery at the GangnamSeverance Hospital between January 2008 and December 2016, were included in this study. The

Background: Bulky or multiple lymph node (LN) metastases are associated with poor prognosis in cervical cancer, and the size or number of LN metastases is not yet reflected in the staging system and therapeutic strategy. Although the therapeutic effects of surgical resection of bulky LNs before standard treatment have been reported in several retrospective studies, well-planned randomized clinical studies are lacking. Therefore, the aim of the Korean Gynecologic Oncology Group (KGOG) 1047/DEBULK

Muscle disorders arise from genetic factors or other external environmental influences, leading to muscle loss and decreased strength. Muscle disease is closely related to age, and with the global progression of aging, there is increas- ing interest in the prevention and treatment of muscle diseases among the elderly population. Muscles release various sub- stances during contraction and relaxation when exercising, and growth and differentiation are enhanced. Similar effects can be achieved by v