신희철 교수

Plasma processes cause current to flow through the thin oxide and the resultant plasma-induced damage can be simulated and modelled as damage produced by constant-current (or voltage) electrical stress. Plasma processing causes MOSFET parameter degradation, from which one can deduce the plasma charging current. Since the scattering of post-damage device parameters is due to a reproducible variation of stress current across the wafer, one can easily analyse the effect of device geometry on damage

PURPOSE: Hereditary cancer syndrome means that inherited genetic mutations can increase a person's risk of developing cancer. We assessed the frequency of germline mutations using an next-generation sequencing (NGS)-based multiple-gene panel containing 64 cancer-predisposing genes in Korean breast cancer patients with clinical features of hereditary breast and ovarian cancer syndrome (HBOC). MATERIALS AND METHODS: A total of 64 genes associated with hereditary cancer syndrome were selected for d

In acute leukemia, leukemic infiltration of the breast is extremely rare. We report a case of biphenotypic acute leukemia (BAL) that presented as a breast mass. A 30-year-old woman presented with a 4-month history of a right breast mass with nipple discharge and easy fatigue. She had received chemotherapy and peripheral blood stem cell transplantation for BAL and had been in complete remission for the last 2 years. Core needle biopsy of the breast mass revealed monomorphous infiltrates of blast

Discordance in receptor status and tumor phenotype between primary breast cancer and corresponding metastatic lesions was observed. Patients with concordant TNP had worse long-term outcomes than patients with concordant non-TNP and discordant TNP between primary and metastatic breast cancer. Identifying the receptor status of metastatic lesions may lead to improvements in patient management and survival.

1039 Background: The receptor status including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) of metastases may be different from that of the primary breast cancer. This discordance of receptor status may influence patient prognosis. We investigated discordance of receptor status between primary breast cancer and distant metastases in the same patients and its effect on prognosis. Methods: ER, PR, and HER2 status in metastases were availab

e12023 Background: The aim of this study was to evaluate the diagnostic performance of ultrasonography (US), breast magnetic resonance imaging (MRI), and 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for axillary lymph node metastasis in breast cancer patients. Methods: Between 2012 and 2013, 180 breast cancer patients received curative breast cancer surgery. Preoperative ultrasonography, breast MRI, and 18F-FDG PET/CT were performed. Complete axillary ly

e13110 Background: Next-generation sequencing technology allows the simultaneous sequencing of multiple target genes. We developed a gene panel containing 64 genes which were associated with various hereditary cancers. This study was performed to evaluate the frequency of pathogenic mutations associated with hereditary cancer among Korean patients at high risk hereditary breast cancer using multi-gene sequencing panel. Methods: A total of 252 breast cancer patients with high-risk hereditary canc