신흥수 교수

Interpenetrating polymer networks (IPNs) composed of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAAc) exhibited electrical-sensitive behavior. PAAc as an initial network was prepared inside a PVA solution using UV irradiation; then, PVA networks as a secondary network were formed by a repetitive freeze–thawing process. Their mechanical properties were influenced by the swelling ratio, crosslinking by UV radiation and a freeze–thawing process, and intermolecular force by hydrogen bonding.

AIMS: Cardiac tissue engineering has been proposed as an appropriate method to repair myocardial infarction (MI). Evidence suggests that a cell with scaffold combination was more effective than a cell-only implant. Nevertheless, to date, there has been no research into elastic biodegradable poly(lactide-co-epsilon-caprolactone) (PLCL) scaffolds. The aim of this study was to investigate the effect of mesenchymal stem cells (MSCs) with elastic biodegradable PLCL scaffold transplants in a rat MI mo

A temperature- and pH-responsive drug delivery system was studied by using interpenetrating polymer network (IPN) hydrogels constructed with poly(acrylic acid) (PAAc) and poly(vinyl alcohol) (PVA). The release of indomethacin incorporated into these hydrogels showed pulsatile patterns in response to both pH and temperature. Indomethacin diffused from the polymer matrices through the swelling and deswelling mechanism. The release amount increased at higher temperature because of the swelling caus

The swelling behaviors of poly(vinyl alcohol)–poly(acrylic acid) (PVA–PAAc) interpenetrating networks (IPN) hydrogels in the presence of electrolytes were studied. The ionized carboxylic group within IPN hydrogels at pH 7 strongly interacted with electrolytes in the medium and caused anomalous swelling pattern. The permeabilities of 5 representative solutes were regulated as a function of temperature, pH, ionic strength, solute size, and ionic properties of solutes. The permeation of nonionic so

Conductive biomaterials with a suitable biocompatibility have been utilized to fabricate in vitro platformsfor differentiation of progenitor cell population as well as implantable tissue engineering scaffolds. Thisreview evaluates biocompatibility of various conductive biomaterials and relevant fabrication techniquesincluding coating, incorporation into composites, and functionalization with biological moieties. Inaddition, recent developments in tissue engineering applications using various con

Background: Bone regeneration research is currently ongoing in the scientific community. Materials approved for clinical use, and applied to patients, have been developed and produced. However, rather than directly affecting bone regeneration, these materials support bone induction, which regenerates bone. Therefore, the research community is still researching bone tissue regeneration. In the papers published so far, it is hard to find an improvement in the theory of bone regeneration. This revi

Regulation of cell-material interactions is an important factor for modulating the cell function in many tissue engineering applications. A more attractive strategy for enhancing the cell-material interactions is to mimic the physical and chemical features of the native extracellular matrix (ECM). The main goal of this study was to develop ECM-like substrates that can control the cell-material interactions including adhesion, spreading, proliferation and differentiation. Poly(L-lactide-co-ε-capr

Adult stem cells have recently drawn considerable attention for potential cell therapy applications. However, critical details about their specific in vivo environments and cellular activities are unclear. Adipose tissue-derived mesenchymal stem cells (ASCs) are attractive candidates for treating bone defects, but most studies focus on delivery of in vitro-differentiated cells. We assessed various scaffolding materials for the ability to support osteogenic differentiation of undifferentiated hum

The development of an artificial matrix is critical as both a substrate to control the cell behavior and as a tool for examining the roles of cellular microenvironment in biology. This study developed cell-interactive hydrogels containing a Arg-Gly-Asp (RGD) peptide, cross-linked via bio-inspired enzymatic processes using H2O2 and horseradish peroxidase (HRP) as the initiators and examined how they controlled myoblast functions. The cell-interactive hydrogels modulated the adhesion and prolifera

A variety of surface modification techniques have been proposed to improve the cell-biomaterial interactions. On the other hand, these processes may cleave long-chained polymers, and compromise their mechanical properties. In this study, dopamine was used as a bridge molecule to immobilize gelatin on the poly(L-lactide-co-ε-caprolactone) (PLCL) fibrous matrices, which may then be used as a cell delivery carrier. The PLCL fibrous matrices coated with polydopamine by dipping (D-PLCL) can subsequen

Poly(vinyl alcohol)(PVA)와 carboxymethyl cellulose sodium salt(CMC)는 우수한 생체적합성 및 수용성 으로 인하여 생체의학 분야에서 주목하는 재료 중 하나이다. 본 연구에서는 PVA와 CMC를 동결/융해 과정과 감마선 조사에 의하여 인공연골로서 사용 가능한 수화젤을 제조하였다. 수화젤 제조시 PVA/CMC의 농도는 PVA는 7 wt%, CMC는 4 wt%로 고정시켰으며, 동결/융해 과정은 2회 반복하였으며, 감마선은 30 kGy 조사하였다. 방사선 조사 전과 후의 겔화율은 눈에 띄는 차이는 보이지 않았으나 팽윤도는 조사 후에 감소하였으며, 겔강도는 증가하였다. CCK-8 assay에 의하여 세포독성이 없는 것으로 확인되었다. 제조된 PVA/CMC 수화젤은 체내에 삽입되는 인공연골 재료로서 사용가능성을 제시하였다.

Background Bone tissue regeneration is regulated by complex events, including inflammation, osteoinduction, and remodeling. Therefore, to induce the complete restoration of defective bone tissue, biomaterials with the ability to regulate the collective bone regenerative system are beneficial. Although some studies conclude that reducing reactive oxygen species created a favorable environment for bone regeneration by controlling inflammation, biomaterials that can simultaneously promote osteogene

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In this study, we prepared polydopamine-gelatin templated electrospun nanofibers, which were coatedwith precisely controlled amounts of biominerals in the form of simulated bodyfluid (SBF). We initiallyinvestigated the effects of different mineral concentrations on the in vitro osteogenic differentiation ofhuman adipose derived stem cells (hADSCs), demonstrating the increase in osteogenic differentiation asa function of mineral concentration without any osteogenic supplements. Meanwhile, in the