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박흥재 교수

Heungjae Park

성균관대학교 의학과 · 의학

연구실 소개

박흥재 교수의 연구실은 만성 신장질환의 새로운 치료 전략 개발을 중심으로, 태반에서 유래한 신장 전구세포 이식을 통한 기능적 신장 조직 재생과 함께, 장내 미생물군의 역할을 규명하는 데 초점을 맞추고 있습니다. 특히 신석질환과 하복부 증후군의 메커니즘을 밝히고, 투여 약물(예: 타마술로신)의 효과를 임상적으로 평가함으로써 개인 맞춤형 치료 전략을 모색하고 있습니다. 이와 더불어, 신장 기능 저하의 생활습관 요인 분석을 통해 예방적 접근도 함께 연구하고 있습니다.

신장 전구세포장내 미생물군신석질환비신경성 배뇨이상타마술로신 치료 효과

연구 현황

논문 수
82
총 인용 수
551
최근 5년 논문
6
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
6총합
2019
2020
2021
2022
2026
5개년 연도별 피인용 수
104총합
20192020202120222026

주요 논문

15
1
논문|인용수 80·2007
What Is the Indication of Varicocelectomy in Men with Nonobstructive Azoospermia?
Joong Shik Lee, Heung Jae Park, Ju Tae Seo
SJR Q2Urology
Reproductive MedicineMedicine
2
논문|인용수 61·2007
Improvement of Kidney Failure With Fetal Kidney Precursor Cell Transplantation
Sang Soo Kim, Heung Jae Park, Joungho Han, So‐Jung Gwak, Moon Hyang Park, Kang Won Song, Yun Hee Rhee, Hyung‐Min Chung, Byung‐Soo Kim
SJR Q1Transplantation

Transplanting fetal kidney precursor cells showed the potential for the partial augmentation of kidney structure and function in the treatment of kidney failure.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
3
논문|인용수 45·2020
Glycemic Status, Insulin Resistance, and the Risk of Nephrolithiasis: A Cohort Study
Seolhye Kim, Yoosoo Chang, Hyun Suk Jung, Young Youl Hyun, Kyu‐Beck Lee, Kwan Joong Joo, Heung Jae Park, Young‐Sam Cho, Hyeonyoung Ko, Eunju Sung, Ho Cheol Shin, Seungho Ryu
SJR Q1American Journal of Kidney Diseases
Pulmonary and Respiratory MedicineMedicine
4
논문|인용수 38·2009
Efficacy and Safety of Tamsulosin for the Treatment of Non-neurogenic Voiding Dysfunction in Females: A 8-Week Prospective Study
Kyu‐Sung Lee, Deok Hyun Han, Young-Suk Lee, Myung‐Soo Choo, Tag Keun Yoo, Heung Jae Park, Hana Yoon, Hyeon Jeong, Sun Ju Lee, Ha Young Kim, Won Hee Park
SJR Q2Journal of Korean Medical ScienceOA

We evaluated the therapeutic effects of tamsulosin for women with non-neurogenic voiding dysfunction. Women who had voiding dysfunctions for at least 3 months were included. Inclusion criteria were age > or =18 yr, International Prostate Symptom Score (IPSS) of > or =15, and maximum flow rate (Q(max)) of > or =12 mL/sec and/or postvoid residuals (PVR) of > or =150 mL. Patients with neurogenic voiding dysfunction or anatomical bladder outlet obstruction were excluded. All patients were classified

UrologyMedicine
5
논문|인용수 38·2022
Gut microbiota and the prevalence and incidence of renal stones
Han‐Na Kim, Jae Heon Kim, Yoosoo Chang, Dongmin Yang, Kwan Joong Joo, Young‐Sam Cho, Heung Jae Park, Hyung‐Lae Kim, Seungho Ryu
SJR Q1Scientific ReportsOA

The role of the gut microbiome in the development of renal stone diseases has not been well characterized. This study focused on the taxonomic and functional profiles of gut microbiomes according to the prevalence and incidence of nephrolithiasis. Stool samples from 915 Korean adults were collected at baseline. Participants were followed for a median of 4.0 years. We evaluated the biodiversity of the gut microbiota and taxonomic profiles associated with nephrolithiasis status, using 16S rRNA gen

Pulmonary and Respiratory MedicineMedicine
6
논문|인용수 30·2007
Kidney Tissue Reconstruction by Fetal Kidney Cell Transplantation: Effect of Gestation Stage of Fetal Kidney Cells
Sang Soo Kim, So‐Jung Gwak, Joungho Han, Heung Jae Park, Moon Hyang Park, Kang Won Song, Seung‐Woo Cho, Yun Hee Rhee, Hyung‐Min Chung, Byung‐Soo Kim
SJR Q1Stem CellsOA

Dialysis and kidney transplantation, current therapies for kidney failure, have limitations such as severe complications, donor shortage, and immune-related problems. The development of an alternative treatment for kidney failure is demanded. The present study shows that the transplantation of fetal kidney cells reconstitutes functional kidney tissue, and that the gestation stage of kidney cells influences the kidney reconstitution. Fetal kidney cells were isolated from metanephroi of rat fetuse

Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
논문|인용수 29·2003
Renal tissue reconstitution by the implantation of renal segments on biodegradable polymer scaffolds
Sang Soo Kim, Heung Jae Park, Joungho Han, Cha Yong Choi, Byung‐Soo Kim
SJR Q2Biotechnology Letters
SurgeryMedicine
8
논문|인용수 26·2000
Tissue-engineering applications for phallic reconstruction
James J. Yoo, Heung Jae Park, Anthony Atala
SJR Q1World Journal of Urology
SurgeryMedicine
9
논문|인용수 23·2010
Efficacy and Safety of Tamsulosin for the Treatment of Non-neurogenic Voiding Dysfunction in Females: A 8-Week Prospective Study
이규성, 한덕현, 이영석, 주명수, 유탁근, 박흥재, 윤하나, 정현, 이선주, 김하영, 박원희
Journal of Korean Medical Science

We evaluated the therapeutic effects of tamsulosin for women with non-neurogenic voiding dysfunction. Women who had voiding dysfunctions for at least 3 months were included. Inclusion criteria were age ≥18 yr, International Prostate Symptom Score (IPSS) of ≥15, and maximum flow rate (Qmax) of ≥12 mL/sec and/or postvoid residuals (PVR) of ≥150 mL. Patients with neurogenic voiding dysfunction or anatomical bladder outlet obstruction were excluded. All patients were classified according to the Blai

10
논문|인용수 23·2018
Sitting time, physical activity and the risk of lower urinary tract symptoms: a cohort study
Heung Jae Park, Chang Hoo Park, Yoosoo Chang, Seungho Ryu
SJR Q1British Journal of UrologyOA

OBJECTIVES: To examine the association of sitting time and physical activity level with the incidence of lower urinary tract symptoms (LUTS) in a large sample of Korean men. MATERIALS AND METHODS: A cohort study was performed in 69 795 Korean men, free of LUTS at baseline, who were followed up annually or biennially for a mean of 2.6 years. Physical activity level and sitting time were assessed using the validated Korean version of the International Physical Activity Questionnaire Short Form. LU

UrologyMedicine
11
논문|인용수 21·2018
Metabolically healthy and unhealthy obesity phenotypes and risk of renal stone: a cohort study
Seolhye Kim, Yoosoo Chang, Kyung Eun Yun, Hyun Suk Jung, Inah Kim, Young Youl Hyun, Kyu‐Beck Lee, Kwan Joong Joo, Heung Jae Park, Ho Cheol Shin, Seungho Ryu
SJR Q1International Journal of Obesity
Pulmonary and Respiratory MedicineMedicine
12
논문|인용수 20·2013
Tuberculosis of testis and prostate that mimicked testicular cancer in young male soccer player
Young Sam Cho, Kwan Joong Joo, Chil Hun Kwon, Heung Jae Park
SJR Q2Journal of Exercise RehabilitationOA

Staphylococcus infection was the most common organism found in infection of athletics, and tuberculosis (TB) was rare. Although genitourinary tuberculosis (GUTB) was the most common subtype of extrapulmonary tuberculosis (EPTB) in the past, it was recently reported to account for less than 0.5% of all patients with EPTB and 1.5% of all patients with pulmonary tuberculosis (TB). And, there are few cases reported about concomitant tuberculous infection of testis and prostate. Pubic pain is a commo

SurgeryMedicine
13
논문|인용수 15·2013
Impact of Treatment With Statins on Prostate-Specific Antigen and Prostate Volume in Patients With Benign Prostatic Hyperplasia
Sang Hun Lee, Tae Ju Park, Min Ho Bae, Sung Ho Choi, Young Sam Cho, Kwan Joong Joo, Chil Hun Kwon, Heung Jae Park
Korean journal of urologyOA

Statin administration reduced PSA and PV in BPH patients. This finding may imply the improvement of lower urinary tract symptoms and prevention of cardiovascular disease and chemoprevention of prostate cancer with statin treatment.

Cancer ResearchBiochemistry, Genetics and Molecular Biology
14
논문|인용수 15·2012
Wilms' Tumor in a Horseshoe Kidney
Sanghun Lee, Min Ho Bae, Sung Ho Choi, Jin Seok Lee, Young Sam Cho, Kwan Joong Joo, Chil Hun Kwon, Heung Jae Park
Korean journal of urologyOA

The incidence of horseshoe kidney is about 1 in 400 cases. The presence of Wilms' tumor with a horseshoe kidney is unusual, and the occurrence of Wilms' tumor in a horseshoe kidney is estimated at 0.4 to 0.9% of all Wilms' tumors. We report the case of a 5-year-old boy who presented with a stage IV Wilms' tumor in a horseshoe kidney. The patient was treated with preoperative chemotherapy followed by surgical resection and adjuvant chemotherapy. This case illustrates the role of preoperative chem

Molecular BiologyBiochemistry, Genetics and Molecular Biology
15
논문|인용수 14·2017
Blood Droplet-Based Cancer Diagnosis via Proteolytic Activity Measurement in Cancer Progression
Jin Woo Choi, Hyungbeen Lee, Gyudo Lee, Yi Rang Kim, Myung‐Ju Ahn, Heung Jae Park, Kilho Eom, Taeyun Kwon
SJR Q1TheranosticsOA

Matrix metalloproteinase (MMP) is a key marker and target molecule for cancer diagnosis, as MMP is able to cleave peptide chains resulting in degradation of extracellular matrix (ECM), a necessary step for cancer development. In particular, MMP2 has recently been recognized as an important biomarker for lung cancer. Despite the important role of detecting MMP molecules in cancer diagnosis, it is a daunting task to quantitatively understand a correlation between the status of cancer development a

Cancer ResearchBiochemistry, Genetics and Molecular Biology

대표 연구 분야

Pulmonary and Respiratory MedicineUrologySurgeryMolecular BiologyEndocrinology, Diabetes and MetabolismReproductive Medicine

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