황정원 교수
Hwang, Jung-Won
서울대학교 마취통증의학과 · 의학
연구실 소개
황정원 교수의 연구실은 마취 및 집중치료 분야에서 환자의 안정적이고 안전한 진료를 위한 약리적 및 생체지표 기반의 임상 연구를 중심으로 전개하고 있습니다. 특히 의료 중재 시 sedation 및 analgesia의 최적화, 예후 예측 지표로 활용 가능한 혈액 생체지표(예: CRP/albumin 비율)의 임상적 의의를 규명하고 있으며, 뇌졸중 및 수술 후 환자의 신경학적 회복 메커니즘에 대한 기전 연구도 진행 중입니다. 이와 함께 마취유도제의 신경보호 작용 및 염증 반응 조절 기전에 대한 기초 연구를 병행하여 임상응용가능성을 높이고자 합니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15BACKGROUND: During fiberoptic bronchoscopy, propofol, ketamine, benzodiazepines, and opiates are most commonly used, alone or in combination for sedation. The aim of this study was to compare the clinical efficacy of propofol/ketamine with propofol/alfentanil for patient-controlled sedation (PCS) during fiberoptic bronchoscopy. METHOD: Patients undergoing fiberoptic bronchoscopy were randomly assigned to receive either propofol/alfentanil (PA group; n = 138) or propofol/ketamine (PK group; n = 1
C-reactive protein and albumin are associated with poor outcomes in critically ill patients. This study aimed to investigate the significance of the C-reactive protein/albumin (CRP/ALB) ratio as a novel prognostic factor for 30-day or 1-year mortality after admission to the postoperative intensive care unit (ICU). This retrospective study was conducted by examining the medical records of postoperative patients aged 19 years or older admitted to the ICU at a tertiary care hospital from January 20
Postoperative CRP, especially CRP POD1-2, can be a useful prognostic factor for both poor outcome and symptomatic vasospasm in patients with aneurysmal SAH.
The purpose of this study was to compare the fracture resistance of copy-milled and conventional In-Ceram crowns. Four groups of 10 uniform sized all-ceramic anterior crowns were fabricated for this test: (1) In-Ceram Spinell (2) In-Ceram Alumina (3) Celay In-Ceram Spinell, and (4) Celay In-Ceram Alumina crowns. All specimens were cemented on stainless steel master die with resin cement and stored in 37 degrees C water for one day prior to loading into a universal testing machine. Using a steel
THE ProSeal™ laryngeal mask airway (PLMA; Laryngeal Mask Co. Limited, Mahe, Seychelles) is a relatively new laryngeal mask device with an added dorsal cuff to improve the seal and a drainage tube to prevent aspiration and gastric insufflation. The PLMA is more difficult to insert at first attempt than the classic laryngeal mask airway, with success rates at first attempt varying between 82% and 100%.1–4Several techniques have been described to improve the insertion success rate; Drolet and Girar
The anti-inflammatory actions of sevoflurane postconditioning are suggested as an important mechanism of sevoflurane postconditioning-induced neuroprotection against cerebral ischemia. Here, we determined whether the anti-inflammatory effects of sevoflurane postconditioning were mediated via inhibition of the toll-like receptor (TLR)-4/nuclear factor kappa B (NF-κB) pathway after global transient cerebral ischemia in rats. Forty-five rats were randomly assigned to five groups as follows: (1) con
A preoperative increase in blood pressure after position change may be a good variable to predict hypotension during spinal anesthesia for cesarean delivery.
: Impact of anesthetics on IOP during laparoscopic surgery may change depending on the surgical position. For the laparoscopic surgery performed in the head-down position, propofol may be more helpful in preventing ocular hypertension.
BACKGROUND: We evaluated the efficacy of glossopharyngeal nerve block (GNB) for the control of post-tonsillectomy pain in adult patients, and correlated the extent of obtunded gag reflex as a clinical indicator of GNB with the extent of pain relief. METHODS: Seventy-five patients undergoing tonsillectomy received bilateral GNB with 0.75% ropivacaine with epinephrine (Group R), 0.5% bupivacaine with epinephrine (Group B) at the end of the operation, or no intervention (Group C). To evaluate the e
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