이향운 교수

Methanol poisoning results in neurological complications including visual disturbances, bilateral putaminal hemorrhagic necrosis, parkinsonism, cerebral edema, coma, or seizures. Almost all reported cases of methanol poisoning are caused by oral ingestion of methanol. However, recently there was an outbreak of methanol poisoning via non-oral exposure that resulted in severe neurological complications to a few workers at industrial sites in Korea. We present 3 patients who had severe neurological

Purpose: The purpose of this study is to investigate the frequency and characteristics of migraine and seizurerelated headache (SRH) according to the criteria of the International Headache Society. Materials and Methods: A questionnaire was undertaken at the initial evaluation of newly referred patients from 32 epilepsy clinics. Results:Of a total of 597 patients, 74 (12.4%) patients had migraine. Age at the onset of epilepsy was lower in patients with migraine than in those without. Twenty-six

Background and Purpose Repetitive transcranial magnetic stimulation (rTMS) has potential as a noninvasive neuromodulation treatment method for various neuropsychiatric disorders,and repeated sessions of rTMS are more likely to enhance the therapeutic efficacy. This study investigated neurophysiologic and spatiodynamic changes induced by repeated 1-Hz rTMS of the temporal cortex using transcranial magnetic stimulation (TMS) indices and fluorodeoxyglucose positron emission tomography (FDG-PET). Me

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous mitochondrial disorder with variable clinical symptoms. Here, from the sequencing of the entire mitochondrial genome, we report a Korean MELAS family harboring two homoplasmic missense mutations, which were reported 9957T＞C (Phe251Leu) transition mutation in the cytochrome c oxidase subunit 3 (COX3) gene and a novel 13849A＞C (Asn505His) transversion mutation in the NA

Objectives:To investigate the sleep patterns of Korean adolescents and the subjective perception on their sleep pattern and daytime functioning related to sleep status.Subjects and methods:The questionnaire survey was done in 2007 for students in middle and high schools located in Mokdong region in Seoul.The questionnaire included sleep/wake schedules both on school days and weekends, various questions regarding sleepiness and other sleep complaints, and morningness-eveningness scale. Results:Th

Background and Purpose Benign childhood epilepsy with centrotemporal spikes (BECTS) does not always have a benign cognitive outcome. We investigated the relationship between cognitive performance and altered functional connectivity (FC) in the resting-state brain networks of BECTS patients. Methods We studied 42 subjects, comprising 19 BECTS patients and 23 healthy controls. Cognitive performance was assessed using the Korean version of the Wechsler Intelligence Scale for Children-III, in additi

Background and Purpose Dopamine agonists are first-line drugs for treating the symptoms of restless legs syndrome (RLS). However, few studies have investigated the effect of dopamine agonists on the quality of life (QoL) in RLS patients. We conducted a study to determine whether ropinirole exerts positive effects on the QoL in RLS patients and to analyze the underlying factors. Methods Primary RLS patients from eight medical centers were recruited in the study. They were evaluated in the baselin

Background and Purpose Obstructive sleep apnea (OSA) is associated with cerebral whitematter changes (WMC), but the underlying mechanisms are not completely understood. Our aim was to identify the cardiovascular autonomic characteristics during sleep that are associated with cerebral WMC in OSA patients. Methods We recruited subjects from our sleep-center database who underwent both polysomnography and brain MRI within a 1-year period. Sixty patients who had OSA with WMC (OSA+WMC), 44 patients w

Background: Methyl alcohol poisoning has been mainly reported in community. Two cases of methyl alcohol poisoning occurred in a small-sized subcontracted factory which manufactured smartphone parts in Korea. Case presentation: One young female patient presented with dyspnea and visual disturbance. Another young male patient presented with visual disturbance and myalgia. They treated with sodium bicarbonate infusion and hemodialysis for metabolic acidosis. In addition, he received ethyl alcohol p

본 연구는 실천 중심 기후변화 교육 프로그램에 참여한 중학생들의 경험 탐색을 통해 기후변화에 대한 행위주체성이 어떻게 드러나는지 살펴보는 것을 목적으로 한다. 이를 위해 프로그램에 참여한 서울과 경기도 지역의 중학생 15명을 연구참여자로 선정하고, 심층 면담, 수업 참여관찰, SNS 소통 내용, 기후 행동 보고서를 데이터로 수집하고 반복적 비교 분석 방법을 통해 질적 분석을 수행하였다. 연구 결과는 연구 참여 중학생들의 행위주체성을 세 가지 경험을 통해 논의하고 있다. 첫째, 중학생들은 기후변화에 대한 탐구와 미션을 수행하면서 추상적으로 여겼던 문제를 자신의 삶과 연결해 구체화하는 ‘자기문제화’ 과정을 거쳤다. 기후변화에 대한 사회의 무관심을 인식하고, 비판적으로 관찰하고, 성찰하는 과정을 통해 기후변화를 해결하기 위한 실천가로 자신을 자리매김하며 스스로에게 권한을 부여하였다. 둘째, 중학생들은 동료들과 기후 행동을 공유하고 연대를 구성하면서, 개인의 실천이 공동체의 실천으로 확장되

The participation of activated leukocytes and subsequent production of chemical mediators has been well accepted in the pathophysiology of hypoxic-ischemic injury. This study was performed to see the effects of leukocytes on hippocampal neuronal damage in transient global ischemia induced by 10-min occlusion of bilateral common carotid arteries (CCAs) with reperfusion for various times, and in complete unilateral ischemia induced by 24-hr ligation of left CCA. Leukopenia was induced by intraperi

ObjectiveaaThe purpose of this study was to investigate the impact of specific behavioral problems on the health-related quality of life (HRQOL) in children and adolescents with epilepsy. MethodsaaChildren and adolescents with epilepsy (n=92; age range=6–17 years) and their mothers completed questionnaires about behavioral problems, HRQOL, socio-demographics, and epilepsy-related variables. To determine significant predictor variables of the HRQOL, the stepwise regression analyses and partial co

Purpose: Treatment for epilepsy primarily involves antiseizure medications (ASMs), which can be characterized using the clinical data warehouse (CDW) database. In this study, we compared retention rates and time to successful treatment for various ASMs to reflect both efficacy and adverse effects in patients with newly diagnosed epilepsy. Materials and Methods: We identified newly diagnosed epilepsy patients with ASM treatment for more than 12 months using CDW of a tertiary referral hospital. Cl

Coagulation profile was investigated in blood drawn from the uterine vein of 12 patients undergoing cesarean section for moderate to moderately severe preeclampsia, and blood drawn peripherally at the same time. An identical study was made in a control group of 12 nontoxemic patients undergoing routine repeat cesarean section. In the control group, platelet counts and fibrinogen levels were always within normal limits, and there was no major difference between peripheral and uterine vein blood;

Abstract—We consider throughput-optimal power allocation in multi-hop wireless networks. The study of this problem has been limited due to the non-convexity of the underlying optimization problems, that prohibits an efficient solution even in a centralized setting. We take a randomization approach to deal with this difficulty. To this end, we generalize the randomization framework originally proposed for input queued switches to an SINR rate-based interference model. Further, we develop distribu