최혜진 교수

Reaction of Co(CF3SO3)2 with the new molecule 1,4-benzenedi(4'-pyrazolyl) (H2BDP) in N,N'-diethylformamide (DEF) at 130 degrees C generates the metal-organic framework Co(BDP).2DEF.H2O (1). X-ray analysis reveals the structure of 1 to contain chains of tetrahedrally ligated Co2+ ions linked through BDP2- ligands to generate a three-dimensional framework with 10 x 10 A2 channels. Thermogravimetric data shows the framework to have a high thermal stability, and complete desolvation occurs upon heat

A metal-organic pillared bilayer open framework having 3D channels, [Ni(2)(C(26)H(52)N(10))](3)[BTC](4).6C(5)H(5)N.36H(2)O (BOF-1, 1), has been assembled from bismacrocyclic nickel(II) complex [Ni(2)(C(26)H(52)N(10))(Cl)(4)].H(2)O and sodium 1,3,5-benzenetricarboxylate (Na(3)BTC). The channels are occupied by pyridine and water guest molecules. When the single crystal of 1 was dried in air and then heated at 75 degrees C for 1.5 h, respectively, [Ni(2)(C(26)H(52)N(10))](3)[BTC](4).30H(2)O (1') a

Novel multidimensional supramolecular networks with brick wall and honeycomb structures, [Ni(C 12 H 30 N 6 O 2 )] 3 [C 6 H 3 (COO) 3 ] 2 ·18H 2 O ( 1 ) and [Ni(C 12 H 30 N 6 O 2 )] 3 [C 6 H 3 (COO) 3 ] 2 ·14H 2 O·2C 5 H 5 N ( 2 ), respectively, have been constructed by the self-assembly of S = 0 Ni(II) macrocyclic complex containing hydroxyl pendent chains and 1,3,5-benzenetricarboxylate (BTC 3- ). The host structures assembled are greatly affected even by the partial change of the guests. X-ray

Reactions between K(3)[M(CN)(6)] and [Mn(5-Brsalen)(H(2)O)(2)](+) (5-Brsalen = N,N'-ethylenebis(5-bromosalicylidene)aminato dianion) in a mixture of methanol and water afford the compounds K[(5-Brsalen)(2)(H(2)O)(2)Mn(2)M(CN)(6)].2H(2)O, with M = Cr (1) or Fe (2). The two compounds are isostructural, each containing a molecular cluster with a linear Mn(III)-NC-M(III)-CN-Mn(III) core and tetragonally elongated coordination about the Mn(III) centers. Magnetic data indicate the presence of weak exc

A three-dimensional network with one-dimensional channels (see picture) has been self-assembled from the nickel(II) complex of cyclam and 1,3,5-benzenetricarboxylate in water through hydrogen-bond formation. The channels have an appropriate diameter (10.3 Å) to include D-glucose with a formation constant of Kf=(1.38±0.01)×104 M−1. Under similar conditions maltose is not included.

Pyrazolate-bridged metal–organic frameworks incorporating tetrahedral Zn2+ ions are shown to exhibit a high chemical stability in boiling water, organic solvents, and acidic media, and are assessed for their hydrogen storage properties.

A 3-D network is self-assembled from a square-planar Ni(II) macrocyclic complex containing hydroxyl pendent chains and a terephthalato (tp2-) ligand. In the crystal, two series of linear chains extending different directions are alternately packed and interconnected by the hydrogen-bonding interactions between the pendent hydroxyl groups and the secondary amines of the macrocycles. The solid is able to bind water reversibly.

BACKGROUND AND AIMS: Biliary tract cancer (BTC) exhibits diverse molecular characteristics. However, reliable biomarkers that predict therapeutic responses are yet to be discovered. We aimed to identify the molecular features of treatment responses to chemotherapy and immunotherapy in BTCs. APPROACH AND RESULTS: We enrolled 121 advanced BTC patients (68 cholangiocarcinomas [33 intrahepatic, 35 extrahepatic], 41 gallbladder cancers, and 12 Ampulla of Vater cancers) whose specimens were analyzed b

BACKGROUND: Sorafenib (Nexavar) is an orally active multikinase inhibitor that is approved for the treatment of hepatocellular carcinoma (HCC). In this study, we used (18) F-2-fluoro-2-deoxyglucose ((18) F-FDG) with positron emission tomography (PET) to predict the treatment outcome of sorafenib in patients with advanced HCC. MATERIALS AND METHODS: A total of 29 patients with HCC were included. Baseline (18) F-FDG PET scans were performed a median of 14 days before sorafenib treatment. Sorafenib

BACKGROUND AND PURPOSE: Dipeptidyl peptidase 4 (DPP4) is an aminopeptidase that is widely expressed in different cell types. Recent studies suggested that DPP4 plays an important role in tumour progression in several human malignancies. Here we have examined the mechanisms by which up-regulation of DPP4 expression causes epithelial transformation and mammary tumourigenesis. EXPERIMENTAL APPROACH: Expression of DPP4 and the peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1), and the cy

A nickel(II) pentaaza macrocyclic complex containing a 1-hexadecyl pendant chain, [Ni(C(25)H(55)N(5))](ClO(4))(2).H(2)O (1), was synthesized by a one-pot metal-template condensation reaction. Crystal data for 1: triclinic, Ponemacr;, a = 8.333(4) A, b = 8.356(3) A, c = 28.374(9) A, alpha = 81.865(19) degrees, beta = 86.242(18) degrees, gamma = 63.871(17) degrees, Z = 2. Solid 1 forms hydrophobic layers that are constructed by the long alkyl chains of the macrocycles. Solid 1 exchanges ClO(4)(-)