강혜진 교수

The aim of this study was to identify brain areas related to apathy or depression in patients with Alzheimer disease (AD). Eighty-one AD patients were enrolled in this prospective study. (99m)Tc-HMPAO single photon emission computed tomography was performed to evaluate regional cerebral blood flow (rCBF). According to the Neuropsychiatric Inventory subscores of apathy and depression, 9 patients were classified as clinically significant (cs) depressed and non-cs-apathetic (D+) groups and 9 were c

본 연구는 주민들의 지역에 대한 만족이 지방정부의 중요한 과제로 떠오르는 상황에서 주민들의 지방정부 서비스에 대한 기대불일치가 지역 만족에 어떠한 영향을 미치는지를 살펴보고자 하였다. 이와 함께 기대불일치와 지역에 대한 주민 만족 사이의 관계를 지방정부에 대한 신뢰가 조절할 가능성이 있는지를 확인하였다. 이를 규명하기 위하여 전국 지방자치단체 주민들을 대상으로 조사한 서베이 자료를 분석하였다. 자료를 분석한 결과, 주민들의 기대불일치는 지역만족도와 거주의사에 부정적인 영향을 미친다는 것을 확인하였다. 또한 이러한 양자의 부정적인 관계는 주민들이 속한 지방정부에 대한 신뢰가 높을수록 완화되는 경향을 보였다. 이러한 분석결과는 다음과 같은 함의를 제시할 수 있을 것으로 보인다. 먼저, 지방정부 주민들이 중요하다고 생각 하는 서비스에 대한 만족도를 높이는 방향으로 서비스의 우선순위를 고려해야한다는 정책적 시사점을 도출해볼 수 있다. 또한, 지방정부에 대한 주민들의 신뢰를 높임으로서 정부에

The human brain naturally integrates audiovisual information to improve speech perception. However, in noisy environments, understanding speech is difficult and may require much effort. Although the brain network is supposed to be engaged in speech perception, it is unclear how speech-related brain regions are connected during natural bimodal audiovisual or unimodal speech perception with counterpart irrelevant noise. To investigate the topological changes of speech-related brain networks at all

BACKGROUND: MicroRNAs, small noncoding RNAs, are conserved in many species, and they are key regulators that mediate post-transcriptional gene silencing. Since biologists cannot perform experiments for each of target genes of thousands of microRNAs in numerous specific conditions, prediction on microRNA target genes has been extensively investigated. A general framework is a two-step process of selecting target candidates based on sequence and binding energy features and then predicting targets

This research attempts to examine how organizational characteristics and environmental characteristics of public organization influence adoption and application of the performance evaluation system and pay-for-performance system. In doing so, internal documents and interviews with personnel managers in KAMCO were analyzed and the adoption of system can be divided into three phases. In the process of examining each phase, it was revealed that the factors contributing to the success of establishin

To explain gating of memory encoding, magnetoencephalography (MEG) was analyzed over multi-regional network of negative correlations between alpha band power during cue (cue-alpha) and gamma band power during item presentation (item-gamma) in Remember (R) and No-remember (NR) condition. Persistent homology with graph filtration on alpha-gamma correlation disclosed topological invariants to explain memory gating. Instruction compliance (R-hits minus NR-hits) was significantly related to negative

This study showed that the proposed likelihood ratio-based false discovery rate method efficiently identifies extensive hypometabolic regions owing to its increased detection capability and ability to control the false discovery rate.

OBJECTIVES: Individuals with early- and late-onset deafness showed different functional and morphological brain changes, but white matter alterations in both deaf groups still need to be elucidated. This study aimed to investigate changes in white matter integrity and white matter anatomical connectivity in both early- and late-onset deaf groups compared with hearing group. DESIGN: Diffusion tensor imaging data from 7 early-onset deaf (50.7 ± 6.5 years), 11 late-onset deaf (50.9 ± 12.3 years), a

Abstract Hyperbolic disc embedding and k -core percolation reveal the hierarchical structure of functional connectivity on resting-state fMRI (rsfMRI). Using 180 normal adults’ rsfMRI data from the human connectome project database, we visualized inter-voxel relations by embedding voxels on the hyperbolic space using the $${\mathbb{S}}^{1} /{\mathbb{H}}^{2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mrow> <mml:mi>S</mml:mi> </mml:mrow> <mml:mn>1</mml:m

Our results suggest that oversynchronisation of left A1 connectivity before rTMS of the left A1 and DLPFC is associated with treatment effectiveness.

This study analyzes the factors influencing the organizational performance of schools in Korea, using the 'governance model'. In recent years, the importance of managerial factors in the public sector has been emphasized. To examine whether this emphasis is justified, this study analyzes data collected from the Korean Educational Panel Study wave II and III. The results of the analysis demonstrate that school leaders' managerial actions are important influential factors, as are parental factors

Abstract The brain presents a real complex network of modular, small-world, and hierarchical nature, which are features of non-Euclidean geometry. Using resting-state functional magnetic resonance imaging (rs-fMRI), we constructed a scale-free binary graph for each subject, using internodal time-series correlation of regions-of-interest (ROIs) as a proximity measure. The resulted network could be embedded onto manifolds of various curvature and dimensions. While maintaining the fidelity of embed

본 연구는 해마가 관여하는 연합기억의 유형을 규명하고자 두 종류의 서로 다른 연합기억 과제를 비교하여, 해마가 활성화 되는 연합기억 과제가 어떤 과제인가를 알아보고자 하였다. 연합 기억의 부호화와 재인 동안 활성화 되는 영역을 정상 성인들(N=16)을 대상으로 fMRI를 이용하여 연구하였다. 연합 기억 과제의 유형에 따라, 명명가능한 선형그림 자극을 그 자극이 제시되었던 위치(좌/우)와 함께 기억하여야 하거나(그림-위치 과제), 인위적으로 짝지워진 다른 선형그림과 함께 기억(그림-그림 과제) 기억 할 것이 요구되었다. 응시 기저 조건에 비하여, 해마는 그림-그림 과제 동안 부호화와 인출 중에 활성화 되었으나 그림-위치 과제 동안은 활성화 되지 않았다. 시각피질과 좌측 전전두엽 및 두정엽의 활성화가 두 과제 모두에서 관찰되었으나 공간적 주의, 또는 탐색이 요구되었을 그림-위치 과제동안에만 우측 상소구에서 활성화가 관찰되었다. 본 연구의 결과는 기억해야 할 정보의 유형의 특성에 따라 해

Purpose : The aim of this study was to identify the brain areas in which reductions of regional cerebral blood flow (rCBF) were correlated with decline of general mental function, measured by Mini-Mental State Examination (MMSE). Materials and Methods : Tc-99m HMPAO brain SPECT was peformed in 9 probable AD patients at the initial and follow-up periods of 1.8 years (average) after the first study. MMSE scores were also measured in both occasions. The mean MMSE score of the initial study 16.4 (ra