Skip to main content

이혁 교수

Hyeok Lee

성균관대학교 의학과 · 의학

연구실 소개

이혁 교수의 연구실은 소화기계 질환, 특히 장내 장벽 기능 이상과 관련된 면역 및 세포 생물학적 메커니즘을 중심으로 연구를 진행하고 있습니다. 특히 장내 비만세포의 역할, 장내 미생물-면역 상호작용, 그리고 암 치료를 위한 나노입자 기반 백신 전략 개발에 초점을 맞추고 있습니다. 최근에는 항우울제의 장기적 효과와 프로톤펌프차단제가 미네랄 대사에 미치는 영향에 대한 임상적 연구도 함께 수행하고 있습니다. 이는 기능성 장질환과 약물 유도성 대사 이상의 병태생리학적 기전을 규명하는 데 기여하고 있습니다.

장내 장벽면역세포항암 백신약물 유도 대사 이상임상 연구

연구 현황

논문 수
411
총 인용 수
10,374
최근 5년 논문
92
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
92총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
333총합
20222023202420252026

주요 논문

15
1
논문|인용수 143·2018
pH-responsive hyaluronate-anchored extracellular vesicles to promote tumor-targeted drug delivery
Hyuk Lee, Hongsuk Park, Gwang Jin Noh, Eun Seong Lee
SJR Q1Carbohydrate Polymers
Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
논문|인용수 117·2013
Mucosal Mast Cell Count Is Associated With Intestinal Permeability in Patients With Diarrhea Predominant Irritable Bowel Syndrome
Hyuk Lee, Jung Ho Park, Dong Il Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Seoung Wan Chae
SJR Q1Journal of Neurogastroenterology and MotilityOA

This study demonstrated a positive correlation between the number of mucosal mast cells and intestinal permeability, suggesting that mucosal mast cells play an important role for increased intestinal permeability in patients with IBS-D.

GastroenterologyMedicine
3
논문|인용수 105·2010
A feasibility study on the expanded indication for endoscopic submucosal dissection of early gastric cancer
Hyuk Lee, Won Kyoung Yun, Byung‐Hoon Min, Jun Haeng Lee, Poong‐Lyul Rhee, Kyoung Mee Kim, Poong‐Lyul Rhee, Jae J. Kim
SJR Q1Surgical EndoscopyOA
Pulmonary and Respiratory MedicineMedicine
4
논문|인용수 101·2017
A cohort study on Helicobacter pylori infection associated with nonalcoholic fatty liver disease
Tae Jun Kim, Dong Hyun Sinn, Yang Won Min, Hee Jung Son, Jae J. Kim, Yoosoo Chang, Sun‐Young Baek, Soohyun Ahn, Hyuk Lee, Seungho Ryu
SJR Q1Journal of Gastroenterology
SurgeryMedicine
5
논문|인용수 101·2014
Clinical safety of endoscopic submucosal dissection compared with surgery in elderly patients with early gastric cancer: a propensity-matched analysis
Chan Hyuk Park, Hyuk Lee, Dong Wook Kim, Hyunsoo Chung, Jun Chul Park, Sung Kwan Shin, Woo Jin Hyung, Sang Kil Lee, Yong Chan Lee, Sung Hoon Noh
SJR Q1Gastrointestinal Endoscopy
Pulmonary and Respiratory MedicineMedicine
6
논문|인용수 97·2010
Efficacy of Venlafaxine for Symptomatic Relief in Young Adult Patients With Functional Chest Pain: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial
Hyuk Lee, Jeong Hwan Kim, Byung‐Hoon Min, Jun Haeng Lee, Hee Jung Son, Jae J. Kim, Poong‐Lyul Rhee, Young Ju Suh, Seonwoo Kim, Poong‐Lyul Rhee
SJR Q1The American Journal of GastroenterologyOA

Venlafaxine, an SNRI antidepressant, significantly improved symptoms in young adult patients with FCP.

Pulmonary and Respiratory MedicineMedicine
7
논문|인용수 88·2013
Long-term outcome of early gastric cancer after endoscopic submucosal dissection: Expanded indication is comparable to absolute indication
Chan Hyuk Park, Suji Shin, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Hyuk Lee
SJR Q1Digestive and Liver DiseaseOA
Pulmonary and Respiratory MedicineMedicine
8
논문|인용수 60·2011
Clinical features and predictive factors of coagulation syndrome after endoscopic submucosal dissection for early gastric neoplasm
Hyuk Lee, Kyung Seok Cheoi, Hyunsoo Chung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee
SJR Q1Gastric CancerOA
Pulmonary and Respiratory MedicineMedicine
9
논문|인용수 58·2015
Covered Metallic Stents With an Anti-Migration Design vs. Uncovered Stents for the Palliation of Malignant Gastric Outlet Obstruction: A Multicenter, Randomized Trial
Hyuk Lee, Byung‐Hoon Min, Jeong Hoon Lee, Cheol Min Shin, Younjoo Kim, Hyunsoo Chung, Sang Hyub Lee
SJR Q1The American Journal of Gastroenterology

WCS group showed comparable migration rate and significantly more durable long-term stent patency compared with UCS group for the palliation of GOO in patients with inoperable gastric cancer.

SurgeryMedicine
10
논문|인용수 50·2017
Palliative gastrojejunostomy versus endoscopic stent placement for gastric outlet obstruction in patients with unresectable gastric cancer: a propensity score-matched analysis
Seung Hyeon Jang, Hyuk Lee, Byung‐Hoon Min, Su Mi Kim, Hye Seung Kim, Keumhee C. Carrière, Yang Won Min, Jun Haeng Lee, Jae J. Kim
SJR Q1Surgical Endoscopy
SurgeryMedicine
11
논문|인용수 49·2014
The efficacy of topical bupivacaine and triamcinolone acetonide injection in the relief of pain after endoscopic submucosal dissection for gastric neoplasia: a randomized double-blind, placebo-controlled trial
Bun Kim, Hyuk Lee, Hyunsoo Chung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee
SJR Q1Surgical Endoscopy
Pulmonary and Respiratory MedicineMedicine
12
논문|인용수 39·2010
IgG4-related sclerosing esophagitis: a case report
Hyuk Lee, Mee Joo, Tae Jun Song, Sun Hee Chang, Hanseong Kim, Yeon Soo Kim, Ji Yoon Ryoo
SJR Q1Gastrointestinal Endoscopy
RheumatologyMedicine
13
논문|인용수 39·2019
Dendritic Cell-Targeted pH-Responsive Extracellular Vesicles for Anticancer Vaccination
Hyuk Lee, Hongsuk Park, Hyeong Sup Yu, Kun Na, Kyung Taek Oh, Eun Seong Lee
SJR Q1PharmaceuticsOA

Immunotherapy can potentially treat cancers on a patient-dependent manner. Most of the efforts expended on anticancer vaccination parallel the efforts expended on prototypical immunization in infectious diseases. In this study, we designed and synthesized pH-responsive extracellular vesicles (EVs) coupled with hyaluronic acid (HA), 3-(diethylamino)propylamine (DEAP), monophosphoryl lipid A (MPLA), and mucin 1 peptide (MUC1), referred to as HDEA@EVAT. HDEA@EVAT potentiated the differentiation and

Molecular BiologyBiochemistry, Genetics and Molecular Biology
14
논문|인용수 37·2013
Clinical Predictors Associated With Proton Pump Inhibitor–Induced Hypomagnesemia
Sunyong Kim, Hyuk Lee, Chan Hyuk Park, Choong Nam Shim, Hyun Jik Lee, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Ha Yan Kim, Dae Ryong Kang
SJR Q2American Journal of TherapeuticsOA

There is increasing evidence and case reports regarding proton pump inhibitor (PPI)-induced hypomagnesemia. Our study aimed to clarify the relationship between PPI use and serum magnesium levels and to specify high-risk patients. We retrospectively studied 112 consecutive patients aged 20 years or older who were treated with PPI for ≥30 days and whose serum magnesium levels were available for the PPI treatment period. We compared the mean level of serum magnesium of the enrolled patients with PP

Nutrition and DieteticsNursing
15
논문|인용수 35·2006
[Peginterferon alfa-2a plus ribavirin for initial treatment of chronic hepatitis C in Korea].
Hyuk Lee, Moon Seok Choi, Seung Woon Paik, Jeong Hwan Kim, Do Young Kim, Joon Hyoek Lee, Kwang Cheol Koh, Byung Chul Yoo, Poong‐Lyul Rhee, Soon Mi Song
PubMed

BACKGROUND/AIMS: Combination therapy with peginterferon and ribavirin is a standard therapy for western patients with chronic hepatitis C; however, its efficacy remains unclear in East Asian patients. We evaluated the efficacy and safety of administering peginterferon alfa-2a plus ribavirin in native Korean patients with chronic hepatitis C. METHODS: Seventy-five patients with detectable HCV RNA (52.0% male, median age: 50.8 years) were eligible for the study. The patients were treated with pegi

HepatologyMedicine

대표 연구 분야

Pulmonary and Respiratory MedicineSurgeryGastroenterologyOncologyMolecular BiologyInorganic Chemistry

이혁 교수의 연구를 Nubint에서 더 깊이 살펴보세요

이 연구실의 논문을 앱에서 열어 AI와 함께 읽고, 핵심을 요약하고, 내 글에 인용하세요.