안형준 교수
Hyoung-Joon Ahn
연세대학교 구강내과 · 의학
연구실 소개
안형준 교수의 연구실은 치의학 분야에서 임상적 의미가 높은 생물학적 마커와 치료적 요법의 효과를 중심으로 연구를 진행하고 있습니다. 특히 혈액학적 지표인 혈小판 평균부피(MPV)와 그 비율이 혈전색전성 질환의 위험도와 관련이 있는지, 간염 바이러스 보유 이식 환자의 예후 및 항바이러스 치료 효과를 분석하는 데 초점을 맞추고 있습니다. 또한, 잇몸 및 구강 기능과 관련된 임상 문제, 예를 들어 템포람디부러리 장애, 보툴리눔 토크신 주사의 치열 기능에 미치는 영향, 그리고 구강칸디다의 형태학적 특성과 치료 반응성에 대한 연구도 활발히 진행되고 있습니다. 이처럼 임상 기반의 정밀의학적 접근을 바탕으로 구강·악안면 질환의 메커니즘과 치료 전략을 탐구하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15The mean platelet volume (MPV) is a laboratory marker associated with platelet function and activity. Increased MPV in thromboembolic disease is considered an important risk factor. The aim of this study was to compare the MPV and MPV/platelet count (MPV/P) ratio between deep vein thrombosis (DVT) and control subjects. We retrospectively reviewed the medical records of patients (n = 91) admitted due to newly diagnosed DVT from December 2010 to March 2012. The control group (n = 311) underwent he
The clinical outcomes of 2,054 renal recipients were examined retrospectively based on pre-transplant hepatitis B surface antigen (HBsAg) status to investigate the efficacy of lamivudine treatment in HBsAg positive recipients. Pre-transplant HBsAg positivity was documented in 66 recipients. The 10-year patient and graft survival rates in Ag positive group were significantly lower than those of Ag negative group (64.4/36.6% vs. 88.2/70.5%, respectively, P < 0.0001). Since 1997, lamivudine was use
This study examined the differences in the masticatory function of patients with temporomandibular disorder (TMD) in Korea. The experimental groups were as follows: 23 patients with painful arthralgia classified as pain group according to the research diagnostic criteria for temporomandibular disorder (RDC/TMC) and 28 patients with pain-free disc displacement and reduction classified as clicking group. The subjects were obtained from those who had visited Yonsei University Dental Hospital from 2
This study examined changes in masticatory function after botulinum toxin type A (BTX-A) injection using objective and subjective tests during 12 weeks. Also, we compared differences in masticatory function between group in which only masseter muscle (M group) was injected and group in which masseter and temporal muscle (M-T group) were injected. Forty subjects were assigned into two groups; M group (n = 20) and the M-T group (n = 20). The Meditoxin(®) was used as BTX-A injection. The mixing abi
Dimorphic Candida exist as commensal yeast carriages or infiltrate hyphae in the oral cavity. Here, we investigated the clinical relevance of Candida hyphae in non-pseudomembranous oral candidiasis (OC) by smears of tongue biofilms. We conducted a retrospective study of 2829 patients who had had tongue smears regardless of OC suspicion. Clinical characteristics were evaluated using a novel method of assessing hyphae. Clinical factors (moderate/severe stimulated pain, pain aggravated by stimulati
The aim of this study was to explore the effect of bleaching agents on the release of metal ions and change in physical and chemical characteristics of amalgams. Amalgam surface changes resulting from bleaching on amalgam were assessed with inductively coupled plasma atomic emission spectrophotometer, an automatic mercury analyzer, a colorimeter, and atomic force microscopy. Analysis of the release of metal ions indicated that the bleaching agent caused more copper, tin, and mercury ions to be r
This analysis of trends in Korean patients seeking OT overseas demonstrates the importance of multilateral approaches to address organ trafficking. National effort to achieve self-sufficiency by increasing activities for organ donations is one of the fundamental solutions to transplant tourism.
BACKGROUND: Polyomavirus (PV) nephropathy may coexist with or follow acute renal transplant rejection. The aim of this study was to evaluate whether HLA-DR and CD54 are useful cellular markers for surveillance of acute rejection in PV-infected patients. METHODS: A prospective study was conducted using 205 renal transplant patients. Urine samples were collected at a regular interval post-transplantation for routine cytology and immunocytochemistry. Urinary levels of tumour necrosis factor alpha,
The microarchitecture of collagen fibrils in the articular disc of the temporomandibular joint (TMJ) plays an important role in dissipating the mechanical load during jaw movement. However, little information is available on its adaptations to the biomechanical environment during development. To address this issue, we analyzed the diameter of collagen fibrils of the articular disc of the rat TMJ with quantitative ultrastructural analysis during postnatal development. The mean diameter of the col
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