변효진 교수

Background: The aim of this study was to explore the use of off-label/unlicensed drugs to confirm the safety and efficacy of their prescription in children in Korea. Methods: In this retrospective study, we analyzed data of patients who received any of the 32 drugs between January–December 2014 in tertiary hospitals in Korea, including demographics, diagnoses, reasons for the medication, administration route, and details of adverse drug reactions. Additionally, the mortality in the cohort was as

Purpose: We aimed to establish the propofol effect-site concentration (Ce) for appropriate sedation by pharmacodynamic analysis and to determine the propofol Ce during occurrence of sedation-related side effects in pediatric patients undergoing brain magneticresonance imaging (MRI). Materials and Methods: In 50 pediatric patients scheduled for brain MRI, sedation was induced with 2.0 mg/kg propofol; additionalpropofol doses were 0.5−1 mg/kg. Propofol Ce was simulated by inputting the propofol ad

Background: Electromagnetic guidance reveals needle alignment and position relative to the image plane on an ultrasound view. This study compared the early learning curves of novices performing ultrasound-guided needle placement with (n = 10) or without electromagnetic guidance (n = 10). Methods: Participants performed 30 ultrasound-guided needle placements using an echogenic stick (0.3-cm diameter) as a target inside a phantom model; this early learning period was divided into sequential period

Epigenetics, the study of heritable changes in gene expression that occur without altering the underlying DNA sequence, has emerged as an important conceptual framework for anesthesiology. The epigenome is organized into three mechanistic tiers: cytosine methylation in DNA, chemical modification of histone proteins, and gene regulation by non-coding RNA molecules. Unlike a relatively stable genome, epigenetic patterns vary between cell types, change throughout the lifespan, and are modifiable by

Objective Children are sedated before undergoing diagnostic imaging tests in emergency medi­cine or pediatric sedation anesthesia units. The aim of this study was to identify variables poten­tially affecting the dose of ketamine required for induction of sedation in pediatric patients un­dergoing diagnostic imaging.Methods This retrospective study included children aged 0 to 18 years who underwent sedation with ketamine for computed tomography or magnetic resonance imaging in the pediatric seda­

Background: Although Lightwand and Glidescope have both shown high success rates for intubation, there has been noconfirmation as to which device is most effective for difficult endotracheal intubation. We compared the Glidescope andLightwand devices in terms of duration of intubation and success rate at the first attempt in a simulated difficult airwaysituation. Methods: Fifty-eight patients were randomized to undergo tracheal intubation with either the Glidescope (Glidescopegroup, n = 29) or t

Safe and effective pediatric sedation depends on multiple factors, including the precise selection of sedative agents, provider expertise, availability of age-appropriate monitoring equipment, and the patients’ individual circumstances. These revised clinical practice guidelines, developed by the Korean Society of Pediatric Anesthesiologists, aim to promote safe and effective pediatric sedation across diverse clinical settings in Korea, thereby enhancing patient safety and standardizing care. Th