조현상 교수
Hyun-Sang Jo
연세대학교 정신과 · 공학
연구실 소개
조현상 교수의 연구실은 신경생물학과 대사질환, 특히 정신질환 치료제가 유발하는 체중 증가와 대사 이상에 대비한 신약 개발 및 메커니즘 규명을 핵심으로 합니다. 특히 아데노신 모노포스페이트 활성화단백키나아제(AMPK)를 타겟으로 하는 천연물질(예: 알파리포산)의 대사 조절 기능을 연구하며, 정신건강과 대사 건강의 상호작용을 다룹니다. 또한 스마트 미터링 기반의 에너지 소비 분석과 활동 인식 기술을 접목해, 환자 행동 분석과 실시간 피드백 시스템 개발에도 기여하고 있습니다. 이는 정신질환 환자의 삶의 질 향상과 예방적 관리 전략 수립에 기여합니다.
연구 현황
연구 성과 추이
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주요 논문
15Recently, energy management has become one of the emerging services in the area of residential network service. A smart meter is the most essential component of advanced metering infrastructure (AMI) that connects the home energy management system of individual residences and a smart grid that optimizes the production, distribution, and consumption of electric power. Power strip type smart meters can be used to not only monitor but also control the electric power consumption at individual power
Weight gain and other metabolic disturbances have now become discouraging, major side effects of atypical antipsychotic drugs (AAPDs). The novel strategies required to counteract these serious consequences, however, should avoid modulating the activities of the neurotransmitter receptors involved because those receptors are the therapeutic targets of AAPDs. Adenosine monophosphate-activated protein kinase is an enzyme that plays a pivotal role in energy homeostasis. We hypothesized that alpha-li
Providing Feedback of power consumption by using Advanced Metering Infrastructure (AMI) and smart meters is considered the best method to lower consumers' power consumption. Automatic analysis of power consumption data that provides information on user activity is essential in order to provide effective feedback in time, and advanced services such as automatic power load control based on context information. The activity should be matched with user's behavior in order to make it understandable f
These results suggest that the APOE ε2 allele operates as a susceptibility gene for combat-related PTSD, with the relationship between alcohol use and PTSD differing according to the ε2-allele status. Future studies should determine the role of the APOE in adaptation to extreme stress, the development of PTSD, and comorbid alcohol-related disorders.
Mitochondrial dysfunction reflects a lifelong cumulative burden of cellular damage, and a decrease in mitochondrial DNA (mtDNA) copy number is associated with oxidative stress and chronic inflammation. The goal of this study was to assess whether mitochondrial dysfunction and a decrease in mtDNA copy number are common features of patients with obstructive sleep apnea syndrome (OSA). We compared mtDNA copy number between 20 healthy volunteers and 20 patients with OSA and investigated whether a si
It has been proposed that positive emotional biases could make bipolar manic (BM) patients maintain abnormally approaching behaviors during social interactions. To test this hypothesis, we measured interpersonal distance (IPD) and gaze angle of BM patients and normal controls (NCs) during social interaction in immersive virtual environment. Overall, IPDs of BM patients (n = 20) were greater than those of normal controls (n = 20). The IPD difference was even greater between NCs and BM patients wi
Familial hemophagocytic lymphohistiocytosis (FHL) is a rapidly fatal illness, usually encountered in infancy, characterized by fever, hepatosplenomegaly, pancytopenia, and central nervous system involvement. Microscopic examination of tissue shows a non-malignant lymphohistiocytic infiltrate, with prominent erythrophagocytosis. FHL is an autosomal recessive hereditary disorder but may develop secondarily to other conditions such as immunosuppression, malignancies, fat overload and certain infect
AIMS: Bipolar disorder is characterized by behavioral changes such as risk-taking and increasing goal-directed activities, which may result from altered reward processing. Patients with bipolar disorder show impaired reward learning in situations that require the integration of reinforced feedback over time. In this study, we examined the behavioral and electrophysiological characteristics of reward learning in manic and euthymic patients with bipolar disorder using a probabilistic reward task.
Paciente de 59 anos de idade, do sexo feminino, procurou nosso departamento com queixa de obstrucao nasal a esquer-da, com dois meses de duracao. O sintoma apresentava pio-ra progressiva e, na consulta otorrinolaringologica foi detec-tado um tumor na coana esquerda. O exame endoscopico revelou um tumor unilateral com base na face superior da parte posterior do septo nasal, na cavidade nasal esquerda. O polipo encontrava-se pendente e solto na coana, ligado a sua base atraves de um fino pediculo
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