안익성 교수
Ik-sung Ahn
연세대학교 화공생명공학과 · 생화학·유전·분자생물학
연구실 소개
안익성 교수의 연구실은 주로 환경 생물공학과 생화학적 반응 메커니즘을 기반으로 한 오염물질 제거 기술 및 생체분자 탐지 기술을 연구하고 있습니다. 특히 희토류 환경오염물질인 나이프탈렌과 다환화합물의 생물분해 메커니즘, 고체상에서의 농도 이동 및 흡착 거동을 수학적 모델링을 통해 규명하고 있으며, 카스파이신 B와 같은 생체효소의 선택적 탐지 및 억제제 개발에도 주력하고 있습니다. 나노입자 기반 효소 고정화 기술을 활용한 고효율 생물촉매 개발도 핵심 연구 분야입니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15The objectives of this work were (1) to demonstrate how the chemostat approach could be modified to allow determination of kinetic parameters for a sparingly soluble, volatile substrate such as naphthalene and (2) to examine the influence of the interactions of various nutrients on possible growth-inhibitory effects of naphthalene. Pseudomonas putida G7 was used as a model naphthalene-degrading microorganism. Naphthalene was found to be toxic to P. putida G7 in the absence of a nitrogen source o
Cathepsin B has been suggested to be a prognostic marker of melanoma, glioma, and a variety of cancers such as brain, breast, colon, esophageal, gastric, lung, ovarian, and thyroid cancers. Cathepsin B inhibitors have also been considered as anticancer drug candidates; hence, there has been a growing need for a probe which enables the selective and simple detection of cathepsin B and its inhibitors. For the purpose of selective assay, a cathepsin B-specific substrate, N,N'-diBoc-dityrosine-glyci
Biological conversion of high-concentration CO<sub>2</sub>in the emission gases using a deep-sea sulfur oxidizing bacterium.
Magnetic particles of size 10 nm have been coated with silica to a mean diameter of 40 nm and charged with Cu2+ ions via a multidentate ligand, iminodiacetic acid (IDA), for the immobilization of His-tagged Bacillus stearothermopilus L1 lipase. Microporous (average pore diameter of 60 Å) silica gel with a mean particle diameter of 115 µm has been used as a comparative support material. The molar ratio of Cu2+ to IDA was found to be 1:1.14 and 1:1.99 in the silica gel and the silica-coated magnet
Three models for sorption/desorption of polycyclic aromatic hydrocarbon (PAH) contaminants from soil were compared for their ability to predict the transport of PAH in soil: a “gamma” model, a “two-site/two-region” nonequilibrium model, and a “hybrid” model. In the “hybrid” model, soil organic matter was conceptually divided into two compartments; a fraction with rapid sorption/desorption kinetics and a compartment with mass-transfer-limited kinetics. Contaminant sorbed in the rapid compartment
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