김인아 교수

Ras activation promotes the survival of tumor cells after DNA damage. To reverse this survival advantage, Ras signaling has been targeted for inhibition. Other contributors to Ras-mediated DNA damage survival have been identified using pharmacologic inhibition of signaling, but this approach is limited by the specificity of the inhibitors used and their toxicity. To better define components of Ras signaling that could be inhibited in a clinical setting, RNA interference was used to selectively b

OBJECTIVE: This study aimed to determine the incidence, prevalence and survival time of Korean patients with amyotrophic lateral sclerosis (ALS) using National Health Insurance Service (NHIS) data. METHODS: Using NHIS data, the Korean nationwide health dataset, we identified patients with motor neuron diseases who were first diagnosed with a KCD-6 code (G12.20-G12.28; modified from ICD-10 codes) between 2011 and 2015. ALS (G12.21 code) epidemiological characteristics, including annual incidence,

OBJECTIVES: The work of public officers involves repeated and long-term exposure to heavy workloads, high job strain and workplace violence, all of which negatively impact physical and mental health. This study aimed to evaluate and compare the incidences of diseases among different categories of public officers in Korea, in order to further understand the health risks associated with these occupations. DESIGN: A cohort study using the National Health Insurance data. PARTICIPANTS: We collated cl

Working hours in Korea are long. There is an association between working hours and depressive symptomatology, and there seems be a trend in working hours and depressive symptomatology.

South Korea has the highest policy priority for working hour regulations because it has longer annual working hours than other Organization for Economic Development Co-operation and Development countries and has fewer holidays. According to the results of the Working Conditions Surveys between 2006 and 2020, in 2020, 6% of wage earners worked for > 52 hours weekly. The percentage of workers exceeding 52 hours weekly has decreased over time; however, disparities exist based on age, industry, occu

OBJECTIVES: Recently, overwork-related disorders have become a major public health concern in Korea. This study investigated the current trends of working hours, causes of death in the working population, and compensation rates. METHODS: We reviewed the current trends of working hours, cause of death statistics in the working population, industrial accident compensation insurance (IACI) statistics, issues of compensation and prevention of work-related cerebro-cardio vascular diseases (CCVDs), me

The aim of this study is to investigate the nationwide incidence and treatment pattern of retinopathy of prematurity (ROP) in South Korea. Using the population-based National Health Insurance database (2007-2018), the nationwide incidence of ROP among premature infants with a gestational age (GA) < 37 weeks (GA < 28 weeks, GA28; 28 weeks ≤ GA < 37 weeks; GA28-37) and the percentage of ROP infants who underwent treatment [surgery (vitrectomy, encircling/buckling); retinal ablation (laser photocoa

목적: 이 연구는 일부 조선업 노동자에 있어서의 작업관련성 근골격계 질환의 실태를 파악하고 근골격계 질환에 관여하는 사회심리학적 위험요인으로서의 노동조건의 변화와 직무스트레스, 그리고 이로 인한 육체적 작업강도와 근골격계 증상과의 관련성을 파악하고자 하였다. 방법: 조선업에 종사하는 1,059명의 남성노동자들을 분석대상으로 하였다. 구조화된 설문을 이용하여 근골격계 증상유무, 사회인구학적 변수, 직무스트레스, 사회심리적 스트레스 수준, 육체적 작업강도, 노동조건의 변화를 평가하였다. 근골격계 증상과 스트레스, 육체적 작업강도, 노동강도의 변화의 관계를 살피기 위하여 단변량 분석과 다중 로짓 회귀 분석을 시행하였다. 결과: 하나 이상의 부위에 대해 기준 1 증상의 유병률은 89.5%였으며 등·허리(58.6%), 어깨(56.3%) 순이었다. 사회인구학적인 변수들을 보정한 후 자세요인(OR=1.06, CI=1.00～1.12), 비자세요인 (OR=1.17, CI=1.05～1.31),

BACKGROUND: The purpose of this study was to investigate the relationship between hormone replacement therapy (HRT) and periodontal disease in postmenopausal women using data from the 4th and 5th Korea National Health and Nutrition Examination Survey (KNHANES). METHODS: The study included data from 5,482 postmenopausal women aged 45-74 years in the 2007-2012 KNHANES. The use of female HRT for at least one month was reclassified as HRT+/HRT-. The Community Periodontal Index of Treatment Needs (CP

Despite technical innovations and health and safety measures, female workers in microelectronics industry in South Korea have high rates of SAB and MA, suggesting continued exposure to reproductive hazards. Further etiologic studies based on primary data collection and careful surveillance are required to confirm these results.

Objectives: This study aimed to reveal the multiple factors that are related to the work-relat - ed musculoskeletal disorders (WMSDs) of shipbuilding workers, and to elucidate the relation - ship between musculoskeletal symptoms and factors such as the change of working conditions, job stress and physical workload. M e t h o d s: The study sample comprised 1,059 shipbuilding workers. A structured-question- naire was used to assess the general characteristics, job stress, psychosocial well-being

The aim of this study is to investigate the epidemiology of ophthalmic complications of retinopathy of prematurity (ROP) after preterm birth using population-based database in South Korea. Using the National Health Insurance database, ophthalmic complications among premature infants born in 2007-2008 during their 10-year follow-up period were identified. Annual cumulative incidence rate and period prevalence of complications at each age were analyzed among those with ROP and those who underwent

Claims due to mental disorders or suicide increased during the 5-year study period, and the approval rate was approximately 33 %, and the main stressor of the claimed cases was an acute stressful event such as physiologic trauma, employment-related issues, fear of legal or financial responsibility, abrupt change in organizational responsibility, or workplace violence.