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변재철 교수

Jae Chul Pyun

연세대학교 신소재공학과 · 의학

연구실 소개

변재철 교수의 연구실은 생체 분석을 위한 고감도 센서 기술과 질병 진단을 목표로 하며, 주로 광학 및 전기화학적 센서, 특히 염색체 기반 면역측정법과 레이저 탈착 이온화 질량분석법(MALDI-TOF MS)을 활용한 의료진단 기술 개발에 집중하고 있습니다. 특히 페로브스카이트 나노결정, 금 나노구조, 산화티타늄 나노와이어 등 고성능 나노소재를 기반으로 한 신호 증폭 및 이온화 효율 향상 기법을 개발하고 있습니다. 이는 세균성 패혈증 등 중증 질환의 조기 진단을 가능하게 하는 핵심 기술로 응용되고 있습니다.

고감도 센서나노소재질량분석면역측정법의료진단

연구 현황

논문 수
247
총 인용 수
4,575
최근 5년 논문
70
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
70총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
571총합
20222023202420252026

주요 논문

15
1
논문|인용수 177·2005
Application of SPR biosensor for medical diagnostics of human hepatitis B virus (hHBV)
J.W. Chung, S.D. Kim, Rita Bernhardt, Jae‐Chul Pyun
SJR Q1Sensors and Actuators B Chemical
Radiology, Nuclear Medicine and ImagingMedicine
2
논문|인용수 94·2014
Chemiluminescence lateral flow immunoassay based on Pt nanoparticle with peroxidase activity
Jong Min Park, Ha-Wook Jung, Young Wook Chang, Hyung-Seok Kim, Min‐Jung Kang, Jae‐Chul Pyun
SJR Q1Analytica Chimica Acta
Molecular BiologyBiochemistry, Genetics and Molecular Biology
3
논문|인용수 85·1998
Development of a biosensor for E. coli based on a flexural plate wave (FPW) transducer
Jae‐Chul Pyun, H. Beutel, J.-U. Meyer, H.H. Ruf
SJR Q1Biosensors and Bioelectronics
Biomedical EngineeringEngineering
4
논문|인용수 78·2014
Development of SPR biosensor for the detection of human hepatitis B virus using plasma-treated parylene-N film
Yong-Hwan Choi, Ga-Yeon Lee, Hyuk Ko, Young Wook Chang, Min‐Jung Kang, Jae‐Chul Pyun
SJR Q1Biosensors and Bioelectronics
Molecular BiologyBiochemistry, Genetics and Molecular Biology
5
논문|인용수 66·2014
Isolation and characterization of the outer membrane of Escherichia coli with autodisplayed Z-domains
Min Park, Gu Yoo, Ji-Hong Bong, Joachim Jose, Min‐Jung Kang, Jae‐Chul Pyun
SJR Q1Biochimica et Biophysica Acta (BBA) - Biomembranes
EcologyEnvironmental Science
6
논문|인용수 65·2006
Immunosensor with a controlled orientation of antibodies by using NeutrAvidin–protein A complex at immunoaffinity layer
J.W. Chung, J.M. Park, Rita Bernhardt, Jae‐Chul Pyun
SJR Q2Journal of Biotechnology
Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
논문|인용수 62·2008
Escherichia coli with autodisplayed Z-domain of protein A for signal amplification of SPR biosensor
Joachim Jose, Jiwon Chung, Byoung-Jin Jeon, Ruth Maas, Chang‐Hoon Nam, Jae‐Chul Pyun
SJR Q1Biosensors and Bioelectronics
Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
논문|인용수 60·2006
Additive assay of cancer marker CA 19-9 by SPR biosensor
J.W. Chung, Rita Bernhardt, Jae‐Chul Pyun
SJR Q1Sensors and Actuators B Chemical
Molecular BiologyBiochemistry, Genetics and Molecular Biology
9
논문|인용수 60·2021
Cesium Lead Bromide (CsPbBr3) Perovskite Quantum Dot-Based Photosensor for Chemiluminescence Immunoassays
Hong‐Rae Kim, Ji-Hong Bong, Jun-Hee Park, Zhiquan Song, Min‐Jung Kang, Dong Hee Son, Jae‐Chul Pyun
SJR Q1ACS Applied Materials & Interfaces

Chemiluminescence immunoassays have been widely employed for diagnosing various diseases. However, because of the extremely low intensity chemiluminescence signals, highly sensitive transducers, such as photomultiplier tubes and image sensors with cooling devices, are required to overcome this drawback. In this study, a hypersensitive photosensor was developed based on cesium lead bromide (CsPbBr<sub>3</sub>) perovskite quantum dots (QDs) with sufficient high sensitivity for chemiluminescence im

Electrical and Electronic EngineeringEngineering
10
논문|인용수 55·2009
E. coli outer membrane with autodisplayed Z-domain as a molecular recognition layer of SPR biosensor
Joachim Jose, Min Park, Jae‐Chul Pyun
SJR Q1Biosensors and Bioelectronics
Radiology, Nuclear Medicine and ImagingMedicine
11
논문|인용수 53·2014
A capacitive biosensor based on an interdigitated electrode with nanoislands
Ha-Wook Jung, Young Wook Chang, Ga-Yeon Lee, Sungbo Cho, Min‐Jung Kang, Jae‐Chul Pyun
SJR Q1Analytica Chimica Acta
Molecular BiologyBiochemistry, Genetics and Molecular Biology
12
논문|인용수 48·2010
Application of a functionalized parylene film as a linker layer of SPR biosensor
Byoung-Jin Jeon, Moo-Hwan Kim, Jae‐Chul Pyun
SJR Q1Sensors and Actuators B Chemical
Molecular BiologyBiochemistry, Genetics and Molecular Biology
13
논문|인용수 46·2017
Chronoamperometry-Based Redox Cycling for Application to Immunoassays
Ga-Yeon Lee, Jun-Hee Park, Young Wook Chang, Sungbo Cho, Min‐Jung Kang, Jae‐Chul Pyun
SJR Q1ACS SensorsOA

In this work, the chronoamperometry-based redox cycling of 3,3',5,5'-tetramethylbenzidine (TMB) was performed by using interdigitated electrode (IDE). The signal was obtained from two sequential chronoamperometric profiles: (1) with the generator at the oxidative potential of TMB and the collector at the reductive potential of TMB, and (2) with the generator at the reductive potential of TMB and the collector at the oxidative potential of TMB. The chronoamperometry-based redox cycling (dual mode

ElectrochemistryChemistry
14
논문|인용수 46·2008
Diamond-like carbon (DLC) microelectrode for electrochemical ELISA
Jo-Il Kim, Adela Bordeanu, Jae‐Chul Pyun
SJR Q1Biosensors and Bioelectronics
Electrical and Electronic EngineeringEngineering
15
논문|인용수 42·2019
Synergistic Effect of the Heterostructure of Au Nanoislands on TiO2 Nanowires for Efficient Ionization in Laser Desorption/Ionization Mass Spectrometry
Moon-Ju Kim, Tae Gyeong Yun, Joo-Yoon Noh, Jong Min Park, Min‐Jung Kang, Jae‐Chul Pyun
SJR Q1ACS Applied Materials & Interfaces

A combination nanostructured matrix with metal Au nanoislands and semiconductor TiO 2 nanowires is presented to enhance both desorption and ionization efficiency in laser desorption/ionization (LDI) mass spectrometry. The heterostructure of Au nanoislands on TiO 2 nanowires was fabricated via (1) TiO 2 nanowire synthesis through a modified wet-corrosion method and (2) Au nanoisland formation through thermal annealing of a sputtered Au layer on the TiO 2 nanowires. Herein, the synergistic effect

SpectroscopyChemistry

대표 연구 분야

Molecular BiologyRadiology, Nuclear Medicine and ImagingSpectroscopyBiomedical EngineeringElectrical and Electronic EngineeringCellular and Molecular Neuroscience

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