이재관 교수
Jae-Gwan Lee
고려대학교 산부인과 · 의학
연구실 소개
이재관 교수의 연구실은 프로젝트 스케줄링 최적화, 유비쿼터스 무선 통신 기술, 바이오의학적 질병 예방, 유전자 발현 조절 메커니즘, 바이러스- mitochondrial 상호작용, 그리고 금속성 비정질 합금의 결정화 거동 등 다양한 분야에서 다학제적 연구를 수행하고 있습니다. 특히 자원 제약과 순서 제약을 고려한 스케줄링 알고리즘 개발과 UWB 필터 설계, 자가면역질환 및 암 예방 전략, 인슐린 수용체 유전자 조절 메커니즘, 지카바이러스에 의한 미토콘드리아 기능 조절, 그리고 고성능 금속 유리의 상형성 메커니즘 분석이 주요 연구 방향입니다. 연구는 이론적 분석과 실험적 검증을 결합하여 실용적 응용 가능성을 확보하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15We develop a search procedure for project scheduling problems with multiple resource constraints as well as precedence constraints. The procedure is applied to three popular search heuristics, simulated annealing, tabu search and genetic algorithms. In the heuristics, a solution is represented with a string of numbers each of which denotes priority of each activity. The priorities are used to select an activity for scheduling among competing ones. The search heuristics with this encoding method
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A novel ultra-wideband (UWB) bandpass filter (BPF) with improved upper stopband performance using a defected ground structure (DGS) is presented in this letter. The proposed BPF is composed of seven DGSs that are positioned under the input and output microstrip line and coupled double step impedance resonator (CDSIR). By using CDSIR and open loop defected ground structure (OLDGS), we can achieve UWB
Our results indicate that in addition to screening for and treatment of CIN, recommendations on the maintenance of an appropriate BMI with an emphasis on physical activity could be an important preventive strategy against the development of cervical cancer.
The functional organization of the human insulin receptor (hIR) promoter was analyzed by deletion mutagenesis and protein-DNA interaction studies. A series of deletion mutants was expressed transiently in two human hepatocytes, HepG2 and PLC. The results revealed that the promoter region between -692 and -345 is essential for efficient transcription of the hIR gene. Multiple trans-acting factors were identified by band shift and footprinting analyses. Sp1 binds to a cluster of GC boxes and two G
Zika virus (ZIKV) remains a global public health threat with the potential risk of a future outbreak. Since viral infections are known to exploit mitochondria-mediated cellular processes, we investigated the effects of ZIKV infection in trophoblast cells in terms of the different mitochondrial quality control pathways that govern mitochondrial integrity and function. Here we demonstrate that ZIKV (PRVABC59) infection of JEG-3 trophoblast cells manipulates mitochondrial dynamics, mitophagy, and f
The kinetic behavior of quasicrystalline phase formation in amorphous Zr65Al7.5Cu12.5Ni10Ag5 alloys has been studied by using differential scanning calorimetry (DSC), x-ray diffractometry, and transmission electron microscopy. DSC trace obtained during continuous heating from 473 to 873 K shows two distinct exotherms with peak temperatures of 727 and 776 K. The first and second exothermic reactions, respectively, correspond to the formation of quasicrystalline phase from the amorphous matrix and
Cervical cancer, the fourth most common cancer among women worldwide, often proves fatal and stems from precursor lesions caused by high-risk human papillomavirus (HR-HPV) infection. Accurate and early diagnosis is crucial for effective treatment. Current screening methods, such as the Pap test, liquid-based cytology (LBC), visual inspection with acetic acid (VIA), and HPV DNA testing, have limitations, requiring confirmation through colposcopy. This study introduces CerviCARE AI, an artificial
BACKGROUND: The association between coffee intake and type 2 diabetes may be modulated by common genetic variation. OBJECTIVE: The purpose of this study was to examine the association between habitual coffee intake and the risk of type 2 diabetes and to determine whether this association varied by genetic polymorphisms related to type 2 diabetes in Korean adults. DESIGN AND METHODS: A population-based cohort study over a follow-up of 4 years was conducted. A total of 4077 Korean men and women ag
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