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구자현 교수

Jae-Hyun Koo

서울대학교 의약학과 · 의학

연구실 소개

구자현 교수의 연구실은 비만, 암 및 신장질환을 비롯한 만성질환의 생물학적 기전과 예후 예측 지표를 규명하는 데 초점을 맞추고 있습니다. 특히 림프절 밀도, 알부민 수치, 백혈구 및 혈소판 지표 등 간단하고 정량화 가능한 생물학적 마커를 활용해 암 환자의 예후를 정밀하게 평가하는 데 기여하고 있으며, 진단 및 치료 전략 수립에 기여할 수 있는 임상적 유용성을 강조합니다. 또한, 단백질 공학을 활용한 항체 모방 단백질 개발을 통해 새로운 진단 및 치료 도구 개발에도 기여하고 있습니다.

예후 마커암 생존율림프절 밀도알부민단백질 공학

연구 현황

논문 수
456
총 인용 수
10,469
최근 5년 논문
53
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
53총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
1,461총합
20222023202420252026

주요 논문

15
1
논문|인용수 254·2020
Creation of bladder assembloids mimicking tissue regeneration and cancer
Eunjee Kim, Seoyoung Choi, Byunghee Kang, JungHo Kong, Yubin Kim, Woong Yoon, Hwa Rim Lee, Sung Eun Kim, Hyo‐Min Kim, Hye Sun Lee, Chorong Yang, You Jeong Lee
SJR Q1Nature
Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
리뷰|인용수 153·2006
The management of neurogenic bladder and quality of life in spinal cord injury
Ja Hyeon Ku
SJR Q1British Journal of Urology
UrologyMedicine
3
논문|인용수 137·2004
Percutaneous nephrostomy versus indwelling ureteral stents in the management of extrinsic ureteral obstruction in advanced malignancies: Are there differences?
Ja Hyeon Ku, Sang-wook Lee, Hwang Gyun Jeon, Hyeon Hoe Kim, Seung‐June Oh
SJR Q2Urology
Pediatrics, Perinatology and Child HealthMedicine
4
논문|인용수 107·2006
Adjuvant systemic chemotherapy in the treatment of patients with invasive transitional cell carcinoma of the upper urinary tract
Cheol Kwak, Sang Eun Lee, In Gab Jeong, Ja Hyeon Ku
SJR Q2Urology
SurgeryMedicine
5
논문|인용수 99·2004
Voiding diary for the evaluation of urinary incontinence and lower urinary tract symptoms: Prospective assessment of patient compliance and burden
Ja Hyeon Ku, In Gab Jeong, Dae Jung Lim, Seok‐Soo Byun, Jae‐Seung Paick, Seung‐June Oh
SJR Q1Neurourology and Urodynamics

AIMS: Voiding diary duration may be related to patient compliance and burden. To test this hypothesis, we evaluated patient compliance and burden. METHODS: Between January and July 2002, we prospectively evaluated 162 patients (57 males and 105 females, mean age 53.0, range 20-81 years) with stress urinary incontinence or lower urinary tract symptoms. At the initial visit, all patients underwent a detailed clinical evaluation including an International Prostate Symptom Score (I-PSS) assessment a

RheumatologyMedicine
6
논문|인용수 90·2005
Health-related quality of life of patients using clean intermittent catheterization for neurogenic bladder secondary to spinal cord injury
Seung‐June Oh, Ja Hyeon Ku, Hwang Gyun Jeon, Hyung‐Ik Shin, Nam‐Jong Paik, Taiwoo Yoo
SJR Q2Urology
UrologyMedicine
7
논문|인용수 89·2007
Potential differentiation of human mesenchymal stem cell transplanted in rat corpus cavernosum toward endothelial or smooth muscle cells
Yongwei Song, H J Lee, I H Park, W K Kim, Ja Hyeon Ku, S U Kim
SJR Q2International Journal of Impotence Research
GeneticsMedicine
8
논문|인용수 80·2007
Tension-free vaginal tape, suprapubic arc sling, and transobturator tape in the treatment of mixed urinary incontinence in women
Jae‐Seung Paick, Seung‐June Oh, Soo Woong Kim, Ja Hyeon Ku
SJR Q2International Urogynecology Journal
RheumatologyMedicine
9
리뷰|인용수 76·2015
Lymph node density as a prognostic variable in node-positive bladder cancer: a meta-analysis
Ja Hyeon Ku, Minyong Kang, Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim
SJR Q2BMC CancerOA

The data from this meta-analysis indicate that LN density is an independent predictor of clinical outcome in LN-positive patients. LN density may be useful in future staging systems, thus allowing better prognostic classification of LN-positive bladder cancer.

SurgeryMedicine
10
논문|인용수 74·2009
Correlation Between Prostatic Urethral Angle and Bladder Outlet Obstruction Index in Patients With Lower Urinary Tract Symptoms
Ja Hyeon Ku, Dong Woo Ko, Jeong Yeon Cho, Seung‐June Oh
SJR Q2Urology
UrologyMedicine
11
논문|인용수 72·1995
Alternate protein frameworks for molecular recognition.
Ja Hyeon Ku, Peter G. Schultz
SJR Q1Proceedings of the National Academy of SciencesOA

In an effort to determine whether proteins with structures other than the immunoglobulin fold can be used to mimic the ligand binding properties of antibodies, we generated a library from the four-helix bundle protein cytochrome b562 in which the two loops were randomized. Panning of this library against the bovine serum albumin (BSA) conjugate of N-methyl-p-nitrobenzylamine derivative 1 by phage display methods yielded cytochromes in which residues Trp-20, Arg-21, and Ser-22 in loop A and Arg-8

Radiology, Nuclear Medicine and ImagingMedicine
12
리뷰|인용수 67·2014
Presence of lymphovascular invasion in urothelial bladder cancer specimens after transurethral resections correlates with risk of upstaging and survival: A systematic review and meta-analysis
Hyung Suk Kim, Myong Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
SJR Q1Urologic Oncology Seminars and Original Investigations
SurgeryMedicine
13
리뷰|인용수 64·2005
Quality of life and psychological factors in chronic prostatitis/chronic pelvic pain syndrome
Ja Hyeon Ku, Soo Woong Kim, Jae‐Seung Paick
SJR Q2Urology
UrologyMedicine
14
리뷰|인용수 63·2007
Health-Related Quality of Life in Patients with Spinal Cord Injury: Review of the Short Form 36-Health Questionnaire Survey
Ja Hyeon Ku
SJR Q2Yonsei Medical JournalOA

Advances in medical and rehabilitative care have increased interest in studying how different factors may affect the health-related quality of life (HRQOL) of individuals with spinal cord injury (SCI). There has been a large increase in the number of studies assessing HRQOL among persons with SCI. However, despite these advances, numerous issues remain unanswered because these studies have used a variety of methodologic approaches and assessment tools to examine how different factors have a role

Pathology and Forensic MedicineMedicine
15
논문|인용수 62·2005
Complications of the upper urinary tract in patients with spinal cord injury: a long-term follow-up study
Ja Hyeon Ku, Won Jun Choi, Kwang Yeom Lee, Tae Young Jung, J.I. Lee, Won Hee Park, Hong Bang Shim
Urological Research
UrologyMedicine

대표 연구 분야

SurgeryPulmonary and Respiratory MedicineUrologyRheumatologyOncologyMolecular Biology

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