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Epidermal growth factor receptor (EGFR) overexpression is common in head and neck squamous cell carcinoma. Targeted therapy specifically directed towards EGFR has been an area of keen interest in head and neck cancer research, as EGFR is potentially an integration point for convergent signaling. Despite the latest advancements in cancer diagnostics and therapeutics against EGFR, the survival rates of patients with advanced head and neck cancer remain disappointing due to anti-EGFR resistance. Th

Cells constantly adjust their metabolic state inresponse to extracellular signals and nutrient availability tomeet their demand for energy and building blocks. Recently, there has been significant research into themetabolic aspects of embryonic stem cells/pluripotent stemcells (ESCs/PSCs) and cancer stem cells (CSCs), which hasrevealed the unique metabolic status of different stem celllineages. While ESCs and CSCs were largely thought toharbor similar metabolic states, recent evidence demonstrat

Nanomaterials have recently received significant attention as photothermal agents and fluorescence contrast agents for molecular therapeutics due to their unique optical properties (e.g. light absorption). In particular, single-walled carbon nanotubes (SWNTs) have been recently utilized as photothermal agents (for photothermal therapy) because of the solubility of SWNTs as well as their light absorbing capability at the near-infrared region. In this work, we have developed the SWNT-based phototh

The purpose of this study was to evaluate the diagnostic performance of magnetic resonance (MR) radiomics-based machine learning algorithms in differentiating squamous cell carcinoma (SCC) from lymphoma in the oropharynx. MR images from 87 patients with oropharyngeal SCC (n=68) and lymphoma (n=19) were reviewed retrospectively. Tumors were semi-automatically segmented on contrast-enhanced T1-weighted images registered to T2-weighted images, and radiomic features (n=202) were extracted from contr

Purpose: Adjuvant radiotherapy (RT) has been performed to reduce locoregional failure (LRF) following radical cystectomy for locally advanced bladder cancer; however, its efficacy has not been well established. We analyzed the locoregional recurrence patterns of post-radical cystectomy to identify patients who could benefit from adjuvant RT and determine the optimal target volume. Materials and Methods: We retrospectively reviewed 160 patients with stage ≥ pT3 bladder cancer who were treated wit

Three-dimensional(3D) structure of specific DNA can be changed between two conformations under an external environmental transition such as pH and salt concentration variations. We have experimentally observed the conformational transitions of i-motif DNA using AFM cantilever bioassay. It is shown that pH change of a solvent induces the bending defleciton change of a cantilever functionalized by i-motif DNA. This indicates that cantilever bioassay enables the label- free detection of DNA structu

The understanding of the endocytosis process of internalized nanomedicines through membrane biomarker is essential for the development of molecular-specific nanomedicines. In various recent reports, the metalloproteases have been identified as important markers during the metastasis of cancer cells. In particular, MT1-MMP has provoked concern due to its protease activity in the degradation of the extracellular matrix adjacent to tumors. Thus, in the current work, we have applied fluorescent Au n

Abstract Cetuximab, an EGFR monocloanal antibody, is commonly known to be an effective treatment agent in head and neck squamous cell carcinoma (HNSCC). However, despite the clinical efficacy of cetuximab, a majority of patients with good initial response still suffer from side effects as the acquired resistance to cetuximab. To understand the mechanisms of acquired resistance to cetuximab, we developed a model by exposing a head and neck cancer cell line Cal27 to increasing concentrations of ce

e21081 Background: Activation of the EGFR signaling can lead to the activation of MAPK, PI3K/AKT, the STAT pathway resulting in tumor growth, inhibition of apoptosis, cell migration and invasion. Tumor cells that over-express both EGFR and HER2, exhibit aggressive tumor cell growth, owing to the increased potential for EGFR/HER2 heterodimerization and signaling. HER2 overexpression has been found to correlate with a worse prognosis in breast cancer. However, the clinical significance of EGFR sta

Background and Objectives This study aimed to investigate the protective effect of poly-deoxyribonucleotide (PDRN) against skin flap necrosis in a murine skin flap model. Materials and Method Twenty mice with rectangular skin flaps on the dorsum were ran-domly divided into the PDRN (n=10) and pentobarbital sodium (PBS) (n=10) injection groups. PDRN (8 mg/kg) was subdermally injected at 12 different points immediately after the opera-tion. After 7 days, the flap perfusions were evaluated using a

Reprogramming of cellular metabolism is an important, emerging, and universal hallmark ofcancer which has received considerable attention during the recent era of cancer research. Cancer cells show characteristic alterations in glucose metabolism in order to fulfill the needsof biosynthesis for tumor proliferation and growth. However, under certain circumstancessuch as invasion and metastasis, cancer cells are prone to metabolic stress and will requiredifferent strategies to meet the high energe

Ultrasonography (US) is noninvasive and offers real-time, low-cost, and portable imaging that facilitates the rapid and dynamic assessment of musculoskeletal components. Significant technological improvements have contributed to the increasing adoption of US for musculoskeletal assessments, as artificial intelligence (AI)-based computer-aided detection and computer-aided diagnosis are being utilized to improve the quality, efficiency, and cost of US imaging. This review provides an overview of c