노재명 교수

The SMC-PTS located in Seoul, Korea, is scheduled to begin treating cancer patients in 2015.

Purpose: We investigated the relationship between BRCA mutations,pathological findings, and magnetic resonance imaging (MRI) features in patients with breast cancer at risk for the mutation. Methods: Genetic testing for BRCA mutations was performed in 275 breast cancer patients with at least one risk factor for the mutation. Using the breast imaging reporting and data system MR lexicon, morphological and kinetic features were reviewed on MRI scans of 230 tumors in 209 patients. The relationship

Objective: To determine the factors associated with tumor volume response to radiotherapy (RT) in cervical cancer patients, and the relationship between the tumor volume response and alteration of the expression of biological markers during RT. Methods: Twenty consecutive patients with cervical squamous cell carcinoma who received definitive RT were enrolled. Tumor volumes were calculated by MRI examinations performed at the start of RT (pre-RT), at the fourth week of RT (mid-RT), and 1 month af

We performed a retrospective analysis to evaluate treatment outcomes and the risk of fatal hemorrhage by tumor regression when definitive concurrent chemo-radiotherapy (CCRT) was delivered to patients with non-small cell lung cancer (NSCLC) invading adjacent great vessels on radiological findings. We selected 37 unresectable NSCLC patients with adjacent great vessel invasion (GVI) by carefully reviewing each patient's images. The criteria of definite GVI were as follows: irregular indentation at

The current study could support that TRT could improve LRC and full dose CTx could improve DMFS and that CCRT plus consolidation CTx could improve DFS.

PurposeThe aim of this study was to examine the clinical implications of a pathologically completeresponse after neoadjuvant chemoradiotherapy (CRT) followed by local excisionfor patients with cT2 rectal cancer who refused radical surgery. Materials and MethodsSeventeen patients with cT2 primary rectal cancer within 6 cm from the anal vergewho received neoadjuvant CRT and local excision because of patient refusal of radicalsurgery or poor performance status were included. Two patients had clinic

We describe two cases of post-radiation sarcoma after breast cancer treatment. The first patient was a 61-year-old woman who underwent partial mastectomy of the right breast and adjuvant whole breast irradiation 7 years previously. Subsequently, a rapidly growing mass from the anterior arc of the right fifth rib was incidentally detected on an abdomino-pelvic computed tomography scan. The second patient was a 70-year-old woman who received neoadjuvant chemotherapy and a partial mastectomy of the

Purpose: We performed exome sequencing in a breast cancer family without BRCA mutations. Materials and Methods: A family that three sisters have a history of breast cancer was selected for analysis. There were no family members with breast cancer in the previous generation. Genetic testing for BRCA mutation was negative, even by the multiplex ligation-dependent probe amplification method. Two sisters with breast cancer were selected as affected members, while the mother of the sisters was a non-

Purpose: To compare the treatment outcomes and to analyze prognostic factors between the use of a breast-conserving treatment (BCT) and a mastectomy for early stage breast cancer. Materials and Methods: We retrospectively reviewed 1,200 patients with pathological stage T1-2N0 breast cancer who received surgery between September 1994 and December 2002 at Samsung Medical Center. We compared the patient characteristics and treatment outcomes between the two treatment groups. Results: Among the 1,17

목 적: 국소적으로 재발한 직장암에 대한 구제 치료방법에 따른 결과 및 치료성적을 알아보고, 생존율에 영향을 주는 예후인자를 알아보고자 하였다. 대상 및 방법: 1994년 10월부터 2003년 12월까지 국소적으로 재발한 직장암으로 삼성서울병원에서 구제 치료로 방사선 치료 단독 혹은 수술이나 항암화학요법이 병행된 45명의 환자를 후향적으로 분석하였다. 환자 연령은 29～72세(중앙값 59세)였고, 남녀 각각 28명(62%), 17명(38%)이었다. 최초 치료 후 무병생존기간은 3～73개월(중앙값 16개월)이었고, 재발부위는 천골 전방 및 직장 주위 25명(56%), 문합 부위 15명(33%), 회음부 3명(7%), 골반벽 2명(4%)이었다. 구제치료로 수술이 시행된 18명(40%)의 환자 중, 14명은 수술 후 방사선치료와 항암화학요법 병행 치료를 받았으며, 나머지 4명은 방사선 치료만을 받았다. 수술을 받지 않은 27명(60%)의 환자 중, 16명은 방사선치료와 항암화학요법을 병

We performed invasive thermometry to verify the elevation of local temperature in the liver during hyperthermia. Materials and Methods: Three 40-kg pigs were used for the experiments. Under general anesthesia with ultrasonography guidance, two glass fiber-optic sensors were placed in the liver, and one was placed in the peritoneal cavity in front of the liver. Another sensor was placed on the skin surface to assess superficial cooling. Six sessions of hyperthermia were delivered using the Celsiu