윤제연 교수

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex d

The current COVID-19 pandemic have affected our daily lifestyle, pressed us with fear of infection, and thereby changed life satisfaction and mental health. The current study investigated influencing cascade of changes during the COVID-19 among the lifestyle, personal attitudes, and life (dis)satisfaction for medical students, using network-based approaches. This cross-sectional survey used self-reports of 454 medical students during June and July of 2020. Depressive mood, anxiety, and intention

BACKGROUND: Demographic, work environmental, and psychosocial features are associated with mental health of healthcare professionals at pandemic frontline. The current study aimed to find predictors of mental health for public health doctors from working experiences at frontline of COVID-19 pandemic. METHODS: With first-come and first-served manner, 350 public health doctors with experiences of work at COVID-19 frontline participated online survey on August 2020. Mental health was defined using

Objective Genetic imaging is used to investigate the mechanism by which genetic variants influence brain structure. In a previous study, a structural change of the dorsolateral prefrontal cortex was associated with symptom modulation in post-traumatic stress disorder patients. This study examined the effect of a polymorphism in the gene encoding brain-derived neurotrophic factor (BDNF) on regional gray matter (GM) volumes and the correlations between the dorsolateral prefrontal GM volume and the

Mild depressive symptoms (MDS) reflect vulnerability to major depression that does not meet the criteria for a major depressive disorder (MDD). Previous research indicates that it is difficult to identify MDS in young adults, and they exhibit diverse aspects of depressive symptoms caused by clinical depression, which can lead to poor academic performance, relationship difficulties, and even suicide. Additionally, many young adults remain unaware of their depressive symptoms during the early stag

Objective: Executive dysfunction might be an important determinant for response to pharmacotherapy in obsessive-compulsive disorder (OCD), and could be sustained independently of symptom relief. The anterior cingulate cortex (ACC) has been indicated as a potential neural correlate of executive functioning in OCD. The present study examined the brain-executive function relationships in OCD from the ACC-based resting state functional connectivity networks (rs-FCNs), which reflect information proce

Anhedonia is an enduring symptom of subthreshold depression (StD) and predict later onset of major depressive disorder (MDD). Brain structural covariance describes the inter-regional distribution of morphological changes compared to healthy controls (HC) and reflects brain maturation and disease progression. We investigated neural correlates of anhedonia from the structural covariance. T1-weighted brain magnetic resonance images were acquired from 79 young adults (26 StD, 30 MDD, and 23 HC). Int

Purpose: The purposes of this study was to verify the effects of the communication skill training program on communication ability, physician empathy, and self-esteem on medical students. Moreover, we also conducted a qualitative analysis by participants’ reports and interviews on the program. Methods: A experimental group was composed of 42 medical students who participated in the communication skill training program and a control group consisted of 40 medical students that participated in a yo

Self-reproach affects decision-making, mediates the impact of social distress on mental health, and is predictive of more severe depressive symptoms in patients with major depressive disorder (MDD) and subthreshold depression (SthD). Resilience and executive functioning promote stress coping. We examined the shared neural correlates of self-reproach, response failure, spatial planning, and resilience in the white matter connectome of patients with SthD. Whole-brain tractograms of the streamlines

본 연구는 서울대학교병원 신경정신과 강박증 클리닉 외래에 내원한 강박증 환자 223명의 의무기록을 검토하여 후향적으로 이루어졌다. 본 연구에서는 연구대상군의 분류 기준으로서 ESC 투여 중 최종 평가시점에서의 CGI-I 점수를 선택하여, 최종 평가시의 CGI-I 점수가 1점 또는 2점에 해당하는증례는 반응군(responder)으로, 그리고 최종 평가시의 CGII 점수가 3점 이상인 증례는 비반응군(non-responder)으로 분류한 후, 반응군과 비반응군 사이에서 강박증의 여러 임상적변인들을 비교하였고, 또한 ESC 투여시의 임상적 반응도를 예측하기 위한 가설적 모형의 타당도를 검증하였다. 이를 통해,공격성 강박증상군을 가지는 강박증 환자들이 이러한 증상을가지지 않는 강박증 환자들의 경우와 비교하여 ESC에 대한 치료반응이 상대적으로 낮음을 알 수 있었고, 강박증 환자에게약물 투여를 시작하기 전 해당 약물에 대한 치료적 반응을 가늠할 수 있는 예측 인자로서 강박증상 종류의 유용성을

Objectives: The current study covers a secondary revision of the guidelines for the pharmacotherapy of schizophrenia issued by the Korean Medication Algorithm for Schizophrenia (KMAP-SCZ) 2001, specifically for co-existing symptoms and antipsychotics-related side-effects in schizophrenia patients. Methods: An expert consensus regarding the strategies of pharmacotherapy for positive symptoms of schizophrenia, co-existing symptoms of schizophrenia, and side-effect of antipsychotics in patients wit

Brain disorders are increasingly understood as disorders of distributed brain circuits, yet functional connectivity (FC), the dominant framework for mapping them, treats the brain as a collection of pairwise relationships between regions and cannot represent pathology distributed across coordinated sets of connections. We introduce a Hodge–Laplacian topological framework that localizes higher–order "loop" (1–cycle) organization within functional connectome, maps each loop to specific edges and n

Brain function is often characterized by the connections and interactions between highly interconnected brain regions. Pathological disruptions in these networks often result in brain dysfunction, which manifests as brain disease. Typical analysis investigates disruptions in network connectivity based correlations between large brain regions. To obtain a more detailed description of disruptions in network connectivity, we propose a new method where functional nodes are identified in each region

Objectives : Previous studies have suggested that some personality characteristics are associated with the onset, prognosis and social function in schizophrenia patients. However few is known about the personality and affective characteristic of genetic high risk group (GHR) for schizophrenia. This study aimed to investigate the personality and the affective characteristic of GHR group for schizophrenia. Methods : Participants were 54 healthy controls (HC), 26 subjects with GHR for schizophrenia