전상학 교수

in glia is essential for the development and maintenance of brain function. We propose a mechanism that underlies these neurodegenerative phenotypes triggered by defective PS metabolism.

In Drosophila, the spatially restricted expression of the homeotic genes is controlled by Polycomb group (PcG) repression. PcG proteins appear to form different complexes to repress this gene expression. Although the pleiohomeotic gene (pho) shares mutational phenotypes with other PcG mutations, which demonstrates that PHO binds directly with a Polycomb (Pc)-containing complex, the genetic interactions of pho with other PcG genes have not been examined in detail. Here we investigated whether pho

An important step in Drosophila neurogenesis is to establish the neural dorsoventral (DV) patterning. Here we describe how dpp loss-of- and gain-of-function mutation affects the homeobox-containing neural DV patterning genes expressed in the ventral neuroectoderm. Ventral nervous system defective (vnd), intermediate neuroblast defective (ind), muscle-specific homeobox (msh), and orthodenticle (otd) genes participate in development of the central nervous system and peripheral nervous system, and

Maintenance of appropriate muscle mass is crucial for physical activity and metabolism. Aging and various pathological conditions can cause sarcopenia, a condition characterized by muscle mass decline. Although sarcopenia has been actively studied, the mechanisms underlying muscle atrophy are not well understood. Thus, we aimed to investigate the role of Phosphatidylserine synthase (Pss) in muscle development and homeostasis in Drosophila. The results showed that muscle-specific Pss knockdown de

Biological sciences have been dramatically changed since the discovery of DNA structure and now biological engineering is expected to be a key industrial area in the twenty-first century. Among several biological areas, "reproduction and development" become more interesting as they are directly related to the maintenance of human beings and recent technological success on these areas. Cloned animals produced by nuclear transplantation and artificial insemination are such cases. In this paper, it

The ventral nerve cord (VNC) of Drosophila exhibits significant segmental-specific characteristics during embryonic development. Homeotic genes are expressed over long periods of time and confer identity to the different segments. castor (cas) is one of the genes which are expressed in neuroblasts along the VNC. However, at late embryonic stages, cas transcripts are found only in head and thoracic segments and terminal abdominal segments, while Cas protein lasts longer in all segments. In this s

Nervous system development takes place after positional information has been established along the dorsal-ventral (D/V) axis. The initial subdivision provided by a gradient of nuclear dorsal protein is maintained by the zygotic genes expressed along the D/V axis. In this study, an investigation was conducted to determine the range of Dpp function in repressing the expression of eagle (eg) that is present in intermediate neuroblasts defective (ind) and muscle specific homeobox (msh) gene domain.

Different proliferation of neuroblast 6-4 (NB6-4) in the thorax and abdomen produces segmental specific expression pattern of several neuroblast marker genes. NB6-4 is divided to form four medialmost cell body glia (MM-CBG) per segment in thorax and two MM-CBG per segment in abdomen. As homeotic genes determine the identities of embryonic segments along theA/P axis, we investigated if temporal and specific expression of homeotic genes affects MM-CBG patterns in thorax and abdomen. A Ubx loss-of-

This study examines the growth of an innovative pre-service science teachers’ (PST) community over a period of three years in a voluntary and informal setting for teaching science to high school students. The objective of this study is to understand the traits and conditions necessary for the learning and development that occurred in the PST group. We describe the growth of the PST group with a focus on the group’s endeavor to move from simple laboratory work to a more inquiry-based approach to

본 연구는 실천적 맥락 속에서 예비교사들의 교직 전문성을 신장시키기 위하여 시범 프로그램을 개발하여 실행하고 그 효과를 확인하려는 목적에서 실시된 탐색적 연구이다. 시범 프로그램은 최근 교직 전문성 함양을 위한 개념으로 주목받고 있는 ‘실천공동체’ 의 원리를 활용하였다. 이 프로그램을 위하여 A 사범대학의 생물교육과 및 사회교육과 예비교사들을 중심으로 공동체를 구성하고 이 대학 부설학교의 지원 하에 운영하였다. 운영 결과, 시범 프로그램은 첫째, 예비교사들에게 이론과 지식을 실제 학생들에게 적용하여 교육과정을 실행하는 기회를 제공하고, 둘째, 협력적 반성을 유도함으로써 예비교사들에게 공동 발전의 기회를 제공했으며, 셋째, 지원 공동체를 구축하여 예비교사들이 안정적으로 과업을 성취할 수 있는 기반을 제공했고, 넷째, 교과전문성과 비교과전문성 신장을 아우르는 프로그램을 제공했다는 의의를 가진다. 향후 시범 프로그램이 정착하기 위해서는 이를 사범대학의 교사양성과정 속에서 어떻게 수용할 수