이정근 교수
Jeong-Geun Lee
연세대학교 신경외과 · 생화학·유전·분자생물학
연구실 소개
이정근 교수의 연구실은 주로 대사질환, 특히obesity의 분자 기전을 규명하고자 하며, 특히 히알루론산과 유사한 점액질이 있는 해양 플랑크톤인 Noctiluca scintillans의 섭취 메커니즘과 그 영향을 연구하고 있습니다. 또한 3T3-L1 전구비만세포를 대상으로 기계적 자극(유동저항)이 지방세포 분화에 미치는 영향을 분석하여 비만 치료 신규 전략을 모색하고 있습니다. 특히 멜라토닌과 기계적 신호가 지방세포 형성에 미치는 조절 메커니즘을 분자 수준에서 규명하는 데 초점을 맞추고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
9Noctiluca scintillans secrets mucus around its tentacle and feeds on the materials trapped in it. The food removal rates in the suspensions of Tetraselmis tetrathelle and Gymnodinium nagasakiense were calculated using a model for filter feeder which is based on the change in food level during the feeding experiment. The clearance rate by starved Noctiluca varied depending upon the food level and experimental duration. With T. tetrathelle, the rate decreased as the food level increased over 4×10⁵
FloWise flow diverter is safe and effective for the treatment of unruptured wide-neck aneurysms.
[This corrects the article DOI: 10.1371/journal.pone.0244102.].
Clinical Research Information Service Identifier: KCT0005660.
Adipocytes are the main constituent of adipose tissue. Understanding the molecular basis of adipogenesis is pivotal to finding the therapeutic targets for treatment of obesity. Melatonin is associated with obesity and its mechanism is currently under intensive investigation. The objective of this study was to investigate the effect of melatonin on adipogenesis in differentiating preadipocytes. 3T3-L1 preadipocytes were cultured in Dulbecco’s modified Eagle’s medium (DMEM) containing 5% calf seru
Adipocytes affect obesity through the regulation of lipid metabolism. Physical loading is an important regulator of fat tissue. There are ongoing in vitro studies inducing mechanotransduction on 3T3-L1 preadipocytes with mechanical stimulus in order to treat obesity by inhibiting adipogenesis and provoking cell death. In this study, our goal was to suggest a new therapy for obesity by investigating whether fluid shear stress (FSS) changes transcription factors on 3T3-L1 related with adipogenesis
Obesity is a worldwide disease caused by the excessive proliferation of adipocytes. Multiple factors, including melatonin and physical loading, are involved in the control of obesity. Melatonin has been shown to induce apoptosis on preadipocytes while physical loading such as fluid shear stress (FSS) affects the proliferation and differentiation of adipocytes. Here, we studied the combined effects of melatonin and FSS on 3T3-L1 preadipocytes. For physical loading, preadipocytes were stimulated w
You have accessJournal of UrologyBladder Cancer: Basic Research IV1 Apr 2014MP39-05 SYNERGISTIC ANTITUMOR EFFECT OF SAHA AND CISPLATIN IN CISPLATIN RESISTANT BLADDER CANCER CELL LINE Ha Rim Kook, Young Ju Lee, Jae Seung Yeon, Han Sol Lee, Choong Hee Noh, Kwang Mo Kim, Ki Beom Kim, Jung Keun Lee, Sangchul Lee, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Eunsik Lee, and Sang Eun Lee Ha Rim KookHa Rim Kook More articles by this author , Young Ju LeeYoung Ju Lee More articles by this author , Jae
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