윤정 교수

Serosurveillance studies reveal the actual disease burden and herd immunity level in the population. In Seoul, Korea, a cross-sectional investigation showed 0.07% anti-severe acute respiratory syndrome coronavirus-2 antibody seropositivity among 1,500 outpatients of the university hospitals. Low seroprevalence reflects well-implemented social distancing. Serosurveillance should be repeated as the pandemic progresses.

The success rate of assisted reproductive technology is closely correlated with maternal age. Reproductive aging pathologies are frequently caused by impaired DNA repair, genomic instability, and mitochondrial dysfunction. Several reports have shown that resveratrol can prevent age-related diseases by improving mitochondrial function. Improved blastocyst development and mitochondrial output by dichloroacetic acid (DCA) supplementation were reported in aged mice. Granulocyte-macrophage colony-sti

MRC media were as effective as Sydney IVF media for sustaining embryo development and pregnancy rates. The present study implies that MRC media can be a suitable alternative to commercially available media for human IVF-ET program.

The findings that a higher proportion of MI-arrested oocytes progressed to MII after fertilization and that the MI-to-MII transition was blocked by Ca²⁺ chelator treatments before fertilization indicate that the maturation of MI oocytes to MII oocytes is associated with intracellular Ca²⁺ oscillations driven by fertilization.

배경: 수혈이상반응(transfusion-related adverse reaction)은 수혈 중이나 후에 환자의 이상 징후혹은 증상에 의하여 인지된다. 수혈관련 징후 및 증상으로 보고된 예 중 실제 수혈이상반응으로진단된 예를 분석하여 실제 수혈이상반응의 빈도를 확인하고, 이를 통하여 본원의 수혈이상반응 보고체계를 점검하였다. 방법: 2015년 1월부터 6월까지 시행된 수혈건수는 총 4,234건이며 사용된 혈액제제의 총 단위는 18,191단위였다. 의료진은 환자가 수혈 받는동안 수혈 5분 후, 수혈 중, 수혈 종료 시로 나눠최소 3차례에 걸쳐 수혈관련 징후 및 증상을 호소하는지 감시하여 전산으로 혈액은행에 보고하였다. 진단검사의학과 담당전문의가 보고된 예를전산의무기록을 통해 조사하고, 수혈이상반응의교과서 진단기준에 합당한지 검토하여, 실제 수혈이상반응의 빈도를 분석하였다. 또한, 혈액제제별 수혈관련 징후 및 증상 및 수혈이상반응의빈도 등을 분석하였다. 결과: 수혈관련 징후 및 증상으

The current study is based upon the trend that the Korean employees tend to place importance on balanced work-family life and their career for high employability in the labor market. Even though many researchers of work-life balance and career management have emphasized on the effects of work-life balance and career management on employees' attitude like organizational commitment and job satisfaction, and turnover intention, this study investigates their impacts on employees' behaviors such as t

Background:The cross-matching test is regarded as an essential pre-transfusion test. It serves an important role in confirming the ABO/Rh compatibility of transfusion and screening for possible unexpected antibodies. We evaluated cross-matching tests in QWALYS-3 (DIAGAST, Loos Cedex, France), comparing the automated process to manual tube methods. Methods:A total of 545 crossmatching tests from 169 patients, collected from RBC concentrate transfusion orders, were performed using both QWALYS-3 an

RhD 혈액형은 ABO 혈액형 다음으로 강한 면역원성을 가지며 신생아 용혈성 질환, 심각한 용혈수혈이상반응 등을 유발할 수 있어 임상적으로중요한 혈액형이다. DEL형은 기본적인 혈청학적검사에서는 검출되지 않으며, 흡착-해리 시험 없이는 D 음성으로 판정되고 RHD 유전자 분석에서만 검출되는 항원이 극소량으로 존재하는 D 변이형이다. DEL형 중 RHD (c.1227G＞A) 대립유전자형은 한국에서 가장 흔하다. DEL형은 항-D항체를 생성하기에는 매우 적은 D항원수를 가지고있다고 여겨 왔으나 이들의 혈액이 D 음성환자에게 수혈시 항-D항체가 생긴 증례가 일부 보고된 바 있다. 이에 저자들은 RhD 음성 환자에서RHD (c.1227G＞A) 대립유전자형의 DEL형 적혈구를 수혈 받은 후 항-D항체가 생성된 1예를 혈청학적 검사 및 유전자분석을 통하여 확인하였기에 보고하는 바이다.

Objective: This study aimed to establish a quantitative and interpretable method for assessing oocyte quality by analyzing cytoplasmic morphology and intensity features using artificial intelligence. Methods: A total of 695 oocyte images were collected from hormonally stimulated young and aged mice. The cytoplasmic region was manually annotated to exclude polar bodies, and radiomics analysis was performed to extract morphological and intensity-based features. Results: Clustering with a Gaussian

Neonatal alloimmune thrombocytopenia (NAIT) occurs when a mother is immunized against fetal platelet-specific alloantigen and rarely human leukocyte antigen (HLA) inherited from the father. We experienced a case of NAIT caused by anti-HLA A29 antibody. The patient was first born female preterm infant. She had no petechiae or purpura and no evidence of infection at birth, but the platelet count was 27,000/mm3. The human platelet antigen specific antibodies were not detected in infant and her moth

The fifth edition of the WHO classification (2022 WHO) and the International Consensus Classification (2022 ICC) of myeloid neoplasms have been recently published. We reviewed the changes in the diagnosis distribution in patients with MDS with excess blasts (MDS-EB) or AML using both classifications. Forty-seven patients previously diagnosed as having AML or MDS-EB with available mutation analysis data, including targeted next-generation and RNA-sequencing data, were included. We reclassified 15