안정천 교수

INTRODUCTION: Action potential duration restitution (APDR) plays a role in initiation and maintenance of ventricular tachycardia (VT)/ventricular fibrillation (VF). We hypothesized that the steeply sloped APDR and its spatial heterogeneity contribute to VT/VF inducibility in patients with ventricular arrhythmia. METHOD AND RESULTS: After programmed ventricular stimulation (PVS) for evaluation of clinically documented VT, patients (n = 20, 15 male, age 52.5 +/- 9.5 years) were divided into two gr

Fixed-dose combinations of ezetimibe/rosuvastatin significantly improved lipid profiles in patients with hypercholesterolemia compared with rosuvastatin monotherapy. All groups treated with rosuvastatin and ezetimibe reported a decrease in mean LDL-C level >50%. The safety and tolerability of ezetimibe/rosuvastatin therapy were comparable with those of rosuvastatin monotherapy. ClinicalTrials.gov identifier: NCT02749994.

Our findings suggest that PWV is an independent risk marker for CAD, as well as strongly associated with the severity of CAD.

Although amiodarone appears to have few pro-arrhythmic effects, torsade de pointes (TdP) has been observed during long-term drug administration, usually in conjunction with electrolyte disturbances, a change in drug dosage, or concomitant drug therapy. We report two cases of amiodarone-induced TdP shortly after administration of a low dose of oral amiodarone, in the absence of predisposing factors.

Our data demonstrated that cilostazol treatment in addition to conventional anti-platelet therapy provides more effective suppression of platelet P-selectin expression in patients with relatively high platelet activity.

Background and Objectives:Aortic stiffness is an independent predictor of cardiovascular mortality and of all other causes in hypertensive patients. The object of this study was to investigate whether aortic stiffness, measured by pulse wave velocity (PWV), could be used as an independent predictor for detecting coronary artery atherosclerosis. Subjects and Methods:PWV was measured by an invasive method. All patients (n=187, M/F= 77/110) were suspected as having the coronary artery disease (CAD)

The aim of this clinical trial was to assess the efficacy and safety of low-dose triple combinations of amlodipine, telmisartan, and chlorthalidone in patients with essential hypertension. After a 2-week placebo run-in period, 176 patients were randomized to seven treatment groups (placebo, quarter-dose combination, third-dose combination, half-dose combination, amlodipine 5 mg, amlodipine 10 mg, and telmisartan 80 mg) and administered the assigned study drug orally for 8 weeks. The primary effi

gov identifier: NCT04584736.

Background and Objectives:Myocardial infarction in young age is an uncommon condition and has few risk factors than old aged group. Hyperhomocysteinemia, which is an independent risk factor for vascular disease, is associated with myocardial infarction (MI. Therefore, we evaluate that hyperhomocysteinemia is associated with myocardial infaction in young age. Materials and Methods:A total 64 patients (normal control 23 (young:old 13:10 mean age 54.2±13.8, M.I 41 (young:old=13:28 mean age 53.9±14.

The mortality showed U-shaped curve and the cut-off value of lowest mortality was 29 in case of BMI and 78 cm of WC. The abdominal obesity may be associated with poor prognosis in Korean patients who underwent PCI.

배경 및 목적： 증가된 대동맥 경직도는 심혈관 질환의 예후에 관한 독립된 예측인자로 알려지고 있다. 이에 대동맥 경직도의 관상동맥 석회화와 협착에 대한 독립적인 예측인자 혹은 위험요인으로서 역할을 알아 보고자 하였다. 방 법： 허혈성 심질환이 의심되어 관상동맥 조영술을 실시한 환자(n=187)를 대상으로, 허혈성 심질환 위험요인, 관상동맥 조영술 소견 상 석회화 침착, 유의한 관상동맥 협착(50%이상의 관동맥 내경 협착), 대동맥 경직도 지표인 대동맥 맥파 전파속도(pulse wave velocity：PWV)를 측정하고 분석하였다. 결 과： 관상동맥석회화(n=46)는 고령(p<0.001), 증가된 허리/ 둔부 표면 둘레 비율(p=0.012), 고혈압(p=0.002), 당 뇨병(p<0.001), 높은 PWV 군(p<0.001)에서 많았다. 유의한 관상동맥 협착(n=79)은 고령(p=0.004), 증가 된 허리/둔부 표면 둘레 비율(p=0.019), 높은 수축기 혈압(p=0.007),

Most coronary arteriovenous fistula (CAVF) drain into the pulmonary artery or the right heart chamber. CAVF between the left coronary artery and left ventricle is very uncommon. Moreover, a case of CAVF from a diagonal branch of the LAD to the LV has not been reported so far. We report a case of a 79-year-old man, complaining of intermittent chest pain and dyspnea on exertion for apprioximately 2 months. CAVF from the diagonal branch of the LAD to the LV was confirmed by selective coronary angio

Background and Objectives:The aims of this study were to compare the lipid distributions and risk factors in an angiographically normal coronary artery group to those of microvascular and coronary artery diseased groups of Koreans, and to find the effects of the variable risk factors on the serum lipid levels according to the coronary atherosclerosis status. Subjects and Methods:A total of 1,198 patients (563 males and 635 females), having undergone a coronary angiography (CAG) using Judkins met