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BACKGROUND: Adipocyte differentiation of human mesenchymal stem cells (hMSCs) is dependent on mitochondrial metabolism and reactive oxygen species (ROS) to initiate adipocyte differentiation. Although anethole has been known as an anti-oxidant and lipid peroxidation inhibitor, there is little investigated about its role in adipogenic differentiation. METHODS: The effects on cytotoxicity and proliferation of anethole in hMSCs were measured by the MTT assay. The anti-adipogenic effect of anethole

Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural and functional properties of lymph nodes (LNs). Here we show that YAP and TAZ (YAP/TAZ), the final effectors of Hippo signaling, regulate FRC commitment and maturation. Selective depletion of YAP/TAZ in FRCs impairs FRC growth and differentiation and compromises the structural organization of LNs, whereas hyperactivation of YAP/TAZ enhances myofibro

During the motion analysis, joint moments are calculated by the inverse dynamics method. The ground reaction forces are representative input data for an application of the inverse dynamics technique, and extracted from an installed force platform. However, when the vast majority of human body movement, continuous and wide spaced, is considered, usage of the fixed force platform on analyzing exercises has many limitations. Therefore, the purpose of this study is to suggest a method to predict the

The efficacy of photodynamic therapy (PDT) depends upon the amount of photosensitizer accumulated in the malignant tissues. Radachlorin is a popular photosensitizer used in photodynamic therapy to treat various types of cancer. In this study, we have studied the main organelles responsible for the accumulation of radachlorin in human anaplastic thyroid cancer in vitro and in vivo. The optimal time window for uptake and clearance of radachlorin also was studied. Confocal microscopic images confir

When the MLNR is higher than 0.44, there is an increased risk of locoregional recurrence mostly in the lateral neck. Therefore, MLNR of the central neck in a permanent or frozen biopsy may be helpful in decision making in the extent of thyroidectomy and/or the need for contralateral central neck lymph nodes dissection.

To determine whether photobiomodulation (PBM) rescued the disruption of Na + /Ca 2+ homeostasis and mitochondrial membrane potential by ouabain; the Na, K-ATPase inhibitor. For PBM in this study, a 660 nm LED array was used at energy densities of 0.78, 1.56, 3.12, 6.24, and 9.36 J/cm 2 . HCN-2 neuronal cells treated with ouabain showed loss of cell polarity, disrupted cell morphology, and decreased cell viability, which were improved after PBM treatment. We found that ouabain-induced Na, K-ATPas

The purpose of this project was to study the effect of growth hormone on early bony consolidation in distraction osteogenesis of a dog model. Sixteen dogs were used for this study. The vertical osteotomy on the mandibular body was extended downward. An external distraction device was applied to the mandibular body and the mandibular distraction was started 5 days after the operation at a rate of 1 mm/d up to a 10-mm distraction. The experimental group was divided into a control group and growth

OBJECTIVE: Transoral surgery is becoming a preferred technique because it does not leave any scar after surgery. However, transoral surgery for a dermoid cyst of the oral cavity is not standardized yet, due to the anatomic complexity of this region. The aim of this study was to evaluate the safety and efficacy of a transoral dermoid cyst excision. STUDY DESIGN: Multicenter prospective observational study. SETTING: University hospital. SUBJECTS AND METHODS: This study was designed as a 4-year pro

Applying the propolis to post-tonsillectomy wound showed beneficial effect of reducing postoperative pain, preventing hemorrhage, and accelerating of wound healing of tonsillar fossae.

OBJECTIVE: Transoral surgery is gaining favor because it has the advantage of leaving no scar after surgery. The aim of this study was to evaluate the technical feasibility and safety of endoscope-assisted transoral accessory parotid mass excision. STUDY DESIGN: Multicenter, prospective, observational study. METHODS: This study was designed as a 7-year, prospective, multicenter evaluation of endoscope-assisted transoral accessory parotid mass excision. Clinical outcomes and complications related

The purpose of this study was to select the appropriate input variables for the development of an expert system to analyze the gait asymmetry of patients with idiopathic scoliosis. Gait experiments were performed with 12 healthy female adolescents and 16 female adolescents with untreated adolescent idiopathic scoliosis. The experimental equipment included six infrared cameras and two ground reaction force platforms. By using a 3D human model, gait elements, kinematic and kinetic data were extrac

Kinematic and kinetic analysis using 3D Motion Capture system are common, yet there is little in the literature that discuss the relationship and coactivity between muscles during the golf swing. The purpose of this study was to describe the relationship between the employed 16 muscles during golf swing. We could observe 3 muscle patterns such as 'Line' shape, 'L' shape, and 'Loop' shape for the golf swing activity. The 'Line' shape indicates that two muscles act almost perfectly in phase, and t