나지훈 교수

The addition of candesartan (an ARB) to propranolol confers no benefit relative to classical propranolol monotherapy for the treatment of portal hypertension, and is thus not recommended.

Purpose: To evaluate the classification, diagnosis, and natural course of ophthalmoplegia associated with mitochondrial disease. Materials and Methods: Among 372 patients with mitochondrial disease who visited our hospital between January 2006 and January2016, 21 patients with ophthalmoplegia were retrospectively identified. Inclusion criteria included onset before 20 years of age, pigmentary retinopathy, and cardiac involvement. The 16 patients who were finally included in the study were divide

Background/Aims: Angiotensin receptor blockers (ARBs) inhibit activated hepatic stellate cell contraction and are thought to reduce the dynamic portion of intrahepatic resistance. This study compared the effects of combined treatment using the ARB candesartan and propranolol versus propranolol monotherapy on portal pressure in patients with cirrhosis in a prospective, randomized controlled trial. Methods: Between January 2008 and July 2009, 53 cirrhotic patients with clinically significant porta

Background and Purpose There is an increasing rate of presentations by transient and adult patients (TAPs) to pediatric emergency departments (PED-EDs). TAPs with neurologic diseases (N-TAPs) comprise most of these patients. We investigated this trend and compared the characteristics of N-TAPs with those of pediatric patients with neurologic diseases (N-PEDs) who presented to the PED-ED of a tertiary-care hospital in Korea. Methods We reviewed the medical records of neurologic patients who prese

Tolosa-Hunt 증후군은 안구 통증과 안구 운동 마비를 특징적으로 나타내는 드문 질환으로 해면정맥동(cavernous sinus)에 육아종성 염증 소견을 보이는질환이다. 저자들은 안구 통증과 두통, 안구 운동 마비를 주소로 내원한 12세 여자 환자에서 뇌 자기공명영상 검사를 통해 Tolosa-Hunt 증후군 진단 후 스테로이드치료로 호전된 증례를 경험 하였기에 문헌 고찰과 함께 보고하는 바이다.

Purpose: Non-alcoholic fatty liver disease (NAFLD) in children has become an important public health issue because of its high prevalence and severity. Several noninvasive methods for estimating NAFLD are under investigation. We aimed to evaluate the usefulness of serum ferritin as a biomarker of severity of pediatric NAFLD patients. Methods: A total of 64 NAFLD patient were enrolled from Severance Children’s Hospital from March 2010 to February 2013. Serum ferritin levels, liver related laborat

InGaAs is a potential candidate for a next-generation channel material of complementary metal-oxidesemiconductordevices based on its excellent electron mobility. In this study, the surface behaviors ofthe InGaAs after treatments in H3PO4/H2O2/H2O and HNO3/H2O2/H2O mixtures were investigated andcompared with that after treatment in a HCl/H2O2/H2O mixture. Although the presence of Cl in an acidicsolution suppressed the overall etching reaction and material loss of the InGaAs surface, Cl induced th

Mitochondrial diseases (MDs) are genetic disorders with diverse phenotypes that affect high-energy-demand organs, notably the central nervous system and muscles. Epilepsy is a common comorbidity, affecting 40%–60% of patients with MDs and significantly reducing their quality of life. This review discusses the different treatment modalities for epilepsy in patients with MDs. Advances in genetic sequencing have identified specific mutations in mitochondrial and nuclear DNA, enabling more precise d

Most ingested foreign bodies pass readily throughout intestinal tract if they reach the stomach. In some cases, foreign bodies may be impacted behind a luminal constriction but are rare in colon. Here, we report the case of a 59-year-old man who did laparoscopic anterior resection due to sigmoid colon cancer 2 years ago and ischemic colitis was repeated on the anastomosis site. He initially presented with symptoms of abdominal pain 3 months before and melena 1 day before admission. Abdomen compu

Purpose: West syndrome is a severe form of age-specific epilepsy that typically affects infants younger than 2 years of age with mitochondrial disease. We aimed to examine age-specific characteristics of the syndrome in these patients. Methods: We retrospectively analyzed 54 patients with West syndrome diagnosed with mitochondrial disease between March 2006 and March 2016. We compared treatment strategies and diagnostic and clinical variables between patients with early-onset (<6 months of age)

Purpose: To analyze the efficacy and safety of nusinersen in patients with spinal muscular atrophy (SMA) type I with chronic re spiratory failure. Materials and Methods: We retrospectively reviewed seven patients diagnosed with SMA type I and chronic respiratory failure who were on permanent ventilation and treated with nusinersen at Gangnam Severance Hospital between January 2018 and July 2023. Patient demographics and clinical characteristics were recorded, and treatment progress was evaluated