박지훈 교수
Ji Hoon Park
연세대학교 외과 · 의학
연구실 소개
박지훈 교수의 연구실은 주로 내 endoscopic 치료 기술의 안전성과 효율성을 높이기 위한 임상 연구와, 생체재료 기반의 혁신적 약물 전달 시스템 개발에 초점을 맞추고 있습니다. 특히 ERCP 후 감염 예방을 위한 항생제 예방요법, 체내 열전달 성능을 향상시킨 열매개물질(TES) 개발, 그리고 생체분해성 마이크로니들을 활용한 피부노화 개선 기술 등 다학제적 접근을 통해 임상적 응용가치가 높은 연구를 수행하고 있습니다. 최근에는 열 손상 없이도 내시경적 점막 재생이 가능한 광역학 치료 기반의 비열성 DMR 기술 개발에도 주력하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15INTRODUCTION: The incidence of postendoscopic retrograde cholangiopancreatography (ERCP) infections is reported to be up to 18% in patients with biliary obstruction. Antibiotic prophylaxis may reduce the risk of infectious complications after ERCP; however, the clinical value of prophylactic antibiotics in ERCP remains controversial. METHODS: We conducted a double-blind, placebo-controlled, randomized trial to investigate whether the use of prophylactic antibiotics would reduce infectious compli
It is desirable to improve the performance of phase change materials (PCM)-based thermal energystorage (TES) systems because it increases energy efficiency while decreasing primary energyconsumption for low environmental loading. Given that PCM suffers from low thermal conductivity(e.g., due to high latent heat capacity and low phase separation), we investigated several efficient optionsto improve the thermal conductivity of organic PCM (n-octadecane) based on the addition of (0.1 wt%)expanded g
We evaluated the proportion of BRCA 1/2 germline mutations in Korean patients with sporadic pancreatic ductal adenocarcinoma (PDAC) and its effect on the chemotherapeutic response of FOLFIRINOX. This retrospective study included patients who were treated at two tertiary hospitals between 2012 and 2020, were pathologically confirmed to have PDAC, and had undergone targeted next-generation sequencing-based germline genetic testing. Sixty-six patients were included in the study (24 men; median age
Background: The transforaminal (TF) epidural steroid injection (ESI) is suggested as more effective than the interlaminar (IL) route due to higher delivery of medication at the anterior epidural space. However, serious complications such as spinal cord injury and permanent neural injury have been reported. The purpose of this study is to evaluate and compare the clinical effectiveness, technical ease, and safety of the TF and parasagittal IL (PIL) ESI.Methods: A total of 72 patients were randomi
Background: Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceuticalmedications into the skin, and is expected to yield better treatment results than topical application methods. Objective: To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor(EGF)-containing microneedle patches on periorbital wrinkle improvement. Methods: A 20-week randomized, double-blind study was performed. Twenty-five Korean pa
Duodenal mucosal resurfacing (DMR) by thermal ablation of the duodenal mucosa is a minimally invasive endoscopic procedure for controlling metabolic syndrome (MS). However, thermal energy can cause adverse effects due to deep mucosal injury, necessitating an additional mucosal lifting process, which complicate the procedures. Therefore, we aimed to develop a similar procedure using non-thermal photodynamic therapy (PDT) for DMR using a highly functional metal stent covered with photosensitizers
A Dual-Path Ethernet Module (DPEM) is developed to improve Local Area Network (LAN)'s performance, High Availability (H/A) and security. Since a DPEM simply locates at the front end of any network device as a transparent add-on, it does not require sophisticated server reconfiguration. Our evaluation results show that the developed scheme is more efficient than conventional LAN structures in various aspects.
Although low-level laser therapy (LLLT) has been a valuable therapeutic technology in the clinic, its efficacy may be reduced in deep tissue layers due to strong light scattering which limits the photon density. In order to enhance the photon density in deep tissue layers, this study developed an optical tissue clearing (OTC) laser probe (OTCLP) system which can utilize four different OTC methods: 1) tissue temperature control from 40 to 10℃; 2) laser pulse frequency from 5 to 30 Hz; 3) glycerol
Acrodermatitis continua of Hallopeau (ACH) is a rare form of acropustular eruption characterized by a presence of aseptic pustules on inflammatory periungual or subungual regions. Frequently accompanied by paronychia, atrophic skin changes, onychodystrophy, and osteolysis of distal phalanges of the digits, it is considered to be a variant of pustular psoriasis with a chronic relapsing course and refractoriness to many therapeutic modalities. Here, we present a case of a 45-year-old female who pr
Sign language translation (SLT) is a technique that translates sign language into spoken language to enable communication between hearing people and Deaf people. However, existing SLT methods rely primarily on RGB image information and are limited by their inability to explicitly reflect non-manual representations of sign languages. To address this issue, we propose an Multi-SLT model that can effectively incorporate non-balance information. First, this study is the first in SLT research to util
Sign Language Translation (SLT) aims to convert visual sign langauge into spoken language, bridging communication between deaf and hearing communities. While gloss-free SLT models bypass the need for costly gloss annotations, they face challenges due to the modality gap between visual and textual representations. We propose CLIP-SLT, a novel architecture that leverages frame level text- aligned representations extracted using the CLIP vision encoder to reduce the modality gap. Additionally, the
PD-L1 expression in immune cells may be used as an independent factor to evaluate the prognosis of patients with BTC.
Existing sign language translation research has improved performance by utilizing glosses in sign language datasets. However, due to the limitations of manually annotating glosses, gloss-free models have been proposed. Since these approaches do not teach glosses in a supervised manner, the model must infer glosses indirectly by utilizing spatially detailed information. However, previous studies have been limited by their inability to provide three-dimensional information of real-world space. To
Brunner's gland adenoma is a rare benign duodenal tumor often discovered incidentally during endoscopy.A 48-year-old male presented with weight loss, dizziness, and melena.Endoscopic examination revealed a large, smooth-surfaced, hyperemic polypoid lesion in the second portion of the duodenum.Computed tomography identified a 6-cm hypoechoic mass, and positron emission tomography demonstrated increased F-fluorodeoxyglucose uptake, raising the suspicion of lymphoma.However, endoscopic ultrasound-g
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