안지현 교수

BACKGROUND: There is conflict regarding the prevalence of coronary artery disease (CAD) in patients with liver cirrhosis. This study aimed to investigate the prevalence of silent CAD in comparison with the general population, and to identify the relevant risk factors in patients with liver cirrhosis. METHODS AND RESULTS: This retrospective study included 1045 prospectively registered consecutive patients with liver cirrhosis without any history of chest pain or CAD, who underwent computerized co

BACKGROUND: Spontaneous portosystemic shunt (SPSS) is a frequent cause of recurrent hepatic encephalopathy (HE) in patients with cirrhosis. AIM: To assess the effectiveness and optimal candidate selection for embolisation of SPSS, for the treatment of recurrent HE in patients with cirrhosis. METHODS: This retrospective cohort study compared 17 patients with recurrent HE who achieved complete occlusion of SPSS by angiographic embolisation and 17 control patients. RESULTS: Most baseline characteri

Background Cognitive impairment may increase the risk of all-cause and cardiovascular disease ( CVD ) mortality. This study examined the association between cognitive function and risk of all-cause and CVD mortality among the elderly in Beijing, China. Methods and Results A total of 1996 participants aged ≥55 years at baseline were enrolled from the BLSA (Beijing Longitudinal Study of Aging). Cognitive function was assessed using the Mini-Mental State Examination ( MMSE ), and participants were

BACKGROUND: Prior epidemiological evidences suggest that hepatitis B virus (HBV) infection is linked to cancers other than hepatocellular carcinoma. This prospective hospital registry-based case-control study aimed to investigate the sero-epidemiological association between chronic HBV infection and various types of cancer. METHODS: 95,034 patients with first-diagnosed non-hepatocellular malignancy in a tertiary hospital between 2007 and 2014; and 118,891 non-cancer individuals as controls from

The survival of HCC patients with bile duct invasion at initial diagnosis is generally poor. However, aggressive treatments for HCC such as resection or biliary drainage may be beneficial therapeutic options for patients with preserved liver function.

본 연구는 대기업 근무환경체제에 대하여 실질적으로 대기업 · 중소기업 내부고객이 느끼는 근무환경과 직무만족에 관한 차이를 규명함으로써 취업자들을 위한 양질의 맞춤 일자리와 관광산업 노동시장의 미스매치 현상에 대한 시사점을 제시하고 높은 이직률로 인한 관광기업들이 우수한 맞춤 인력을 확보하기위한 목적으로 시도되었다. 본 연구의 분석을 위하여 국내 호텔, 여행사, 항공사 내부고객을 대상으로 설문조사를 실시하였고 빈도분석, 신뢰성분석, 요인분석, MANOVA분석이 이용되었다. 연구결과 각 기업별로 외재적 직무만족에는 유의한 차이가 없는것으로 나타났지만 내재적 근무환경과 사회적 근무환경에는 유의한차이가 있는 것으로 나타났다. 또한 직무만족요인에서도 내재적 직무만족과 사회적 직무만족은 뚜렷한 차이를 보였으나 외재적 직무만족에는 유의한 차이가 없는것으로 나타났다. 따라서 관광기업은 규모 큰 대기업이라고 해서 내부고객의 근무환경과 직무만족이 높은 것은 아닌 것으로 나타났다. 특히 호텔은 내재적

BACKGROUND AND AIMS: Despite the epidemiological association between intrahepatic cholangiocarcinoma (iCCA) and HBV infection, little is known about the relevant oncogenic effects. We sought to identify the landscape and mechanism of HBV integration, along with the genomic architecture of HBV-infected iCCA (HBV-iCCA) tumors. APPROACH AND RESULTS: We profiled a cohort of 108 HBV-iCCAs using whole-genome sequencing, deep sequencing, and RNA sequencing, together with preconstructed data sets of HBV

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease globally, and its prevalence is rapidly increasing. Nonalcoholic steatohepatitis (NASH), a progressive form of NAFLD, is characterized by hepatocellular injury, inflammation, and fibrosis. Patients with NASH or severe fibrosis should be treated according to international NAFLD guidelines. Currently, regulatory agencies have not approved any pharmaceutical treatment for NAFLD. Vitamin E and pioglitazone are efficac

DAA therapy is known to clear hepatitis C virus infection in patients with decompensated cirrhosis (DC). However, the safety and benefits of DAA in DC remain unclear, especially with the use of protease inhibitors (PI). Therefore, we evaluated the efficacy and clinical safety of DAA in DC patients and observed whether there was a discrepancy between PI-based and non-PI-based treatment. We searched Ovid-Medline, Ovid-EMBASE, Cochrane Library, and three local medical databases through October 2021

오늘날 한류는 국가이미지의 위상을 높이고 국가에 대한 충성심을 대·내외적으로 고양시키는 데에 중요한 역할을 하고 있다. 그러나 한류는 드라마와 가요 등의 특정 대중문화 영역으로의 편중과 소수의 한류스타만을 앞세운 스타 마케팅으로 한계를 보여 왔다. 이러한 한류의 창조적이고 흥미로운 콘텐츠의 한계에 대한 우려로 인해, 많은 사람들은 한류의 성장을 위한 지속가능성의 방법을 모색하고 있다. 다시 말해, 현시점에서 싸이의 ‘강남스타일’과 같은 문화콘텐츠의 중요성이 강조되고 있는 것이다. 이와 관련하여, 본 연구는 ‘강남스타일’을 중심으로 문화콘텐츠의 중요성에 대해 고찰하였다. 또한 ‘강남스타일’이 가져온 성공 요인과 OSMU의 콘텐츠 다목적활용에 대한 인과분석을 실시하였다. 분석결과, 강남스타일의 성공요인은 문화적 원천소스의 중요성에 의한 것으로 나타났다. 또한 싸이의 성공은 소셜미디어와 크라우드소싱으로 계기로 점차 확산되었음을 알 수 있었다. 특히, SNS세대에 힘입어 2차 산업으로까지

BACKGROUND/AIMS: The assessment of liver fibrosis is crucial for managing autoimmune liver diseases such as primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC). However, data on the efficacy of noninvasive tests for these diseases are limited. This meta-analysis evaluated the diagnostic accuracy of vibration-controlled transient elastography (VCTE) for staging fibrosis in patients with autoimmune liver disease. METHODS: Searches were conducted

BACKGROUNDS AND AIMS: We performed an in-depth examination of pathogenic germline variants (PGVs) and somatic variants in DNA damage response (DDR) genes in hepatocellular carcinoma (HCC) to explore their clinical and genomic impacts. APPROACH AND RESULTS: We used a merged whole-exome or RNA sequencing data set derived from in-house ( n = 230) and The Cancer Genome Atlas ( n = 362) databases of multiethnic HCC samples. We also evaluated synthetic lethal approaches targeting mutations in homologo

Hepatitis A virus (HAV) infections occur predominantly in children, and are usually self-limiting. However, 75-95% of the infections in adults are symptomatic (mostly with jaundice), with the illness symptoms usually persisting for a few weeks. Atypical manifestations include relapsing hepatitis, prolonged cholestasis, and complications involving renal injury. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, drug-induced hypersensitivity reaction characterized by s

BACKGROUND: Telbivudine has been suggested to induce hepatitis B surface antigen (HBsAg) decline to the similar degree as pegylated interferon. We aimed to investigate whether telbivudine could further decrease HBsAg titer in patients who maintain undetectable serum hepatitis B virus (HBV) DNA after initial entecavir treatment. METHODS: In this open-label trial, patients who had serum HBsAg and HBV DNA levels ≥1,000 IU/mL and <60 IU/mL, respectively, following entecavir (0.5 mg/day) treatment fo

Although antiviral prophylaxis is essential in hepatitis B patients in the context of cancer chemotherapy, there is little evidence-based consensus regarding the appropriate prevention strategy depending on the underlying type of cancer and viral status. This retrospective study included a comprehensive cohort of 302 hepatitis B surface antigen-positive patients with various cancers undergoing chemotherapy and antiviral prophylaxis. The rates of hepatitis B virus (HBV) reactivation during antivi