오지원 교수

Objective: The objective of this study is to provide a comparative analysis of variant clusters and their relevance across Africa, America, Europe, and Asia, in order to understand the evolutionary patterns of the virus across different regions and to inform the development of targeted interventions and genomic surveillance eforts. Methods: The study analyzed the global lineage evolution pattern of 74, 075 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from 32 countries acr

Summary The trillions of cells that constitute the human body are developed from a fertilized egg through embryogenesis. However, cellular dynamics and developmental outcomes of embryonic cells in humans remain to be largely unknown due to the technical and ethical challenges. Here, we explored whole-genomes of 334 single-cell expanded clones and targeted deep-sequences of 379 bulk tissues obtained from various anatomical locations from seven individuals. Using the discovered 1,688,652 somatic m

The transition to a fully aquatic lifestyle in cetaceans, baleen and toothed whales, was accompanied by sweeping changes in their body plan, anatomy and physiology. Detailed fossil records of ancestral forms between land-dwelling mammals and modern-day cetaceans enshrine whales in biology textbooks as an example of macroevolution 1. The advent of mainstream sequencing technologies has allowed the whole genomes of several cetacean species to be assembled and provisionally annotated. This exciting

Maintenance of trichogenecity of dermal papilla cells (DPCs) have been a problem during cell therapy for androgenic alopecia, as they lose their regenerative potential in in vitro culture. Various spheroid culture techniques are used to increase and maintain trichogenecity of these cells. However, there are some critical drawbacks in these methods. Applying a hydrocell plate for sphere formation or hanging drop methods by hand would be difficult to control the size and cell density inside it. It

Blood vessels are three-dimensional (3D) in structure and precisely connected. Conventional histological methods are unsuitable for their analysis because of the destruction of functionally important topological 3D vascular structures. Tissue optical clearing techniques enable extensive volume imaging and data analysis without destroying tissue. This study therefore applied a tissue clearing technique to acquire high-resolution 3D images of rat brain vasculature using light-sheet and confocal mi

Curiosity concerning the process of human creation has been around for a long time. Relevant questions seemed to be resolved with the knowledge of how cells divide after fertilization obtained through in vitro fertilization experiments. However, we still do not know how human life is created at the cellular level. Recently, the value of cadavers as a resource from which to obtain "normal" cells and tissues has been established, and human research using postmortem bodies has attracted growing sci

Hairs and feathers are some of the most distinguishing characteristics of mammals and birds, respectively. The origin of these skin mini-organs is a fascinating, yet poorly understood topic in the Evolutionary Biology 1. The first definitive fossil evidence of hairs dates back to a mid-Jurassic period to Castorocauda lutrasimilis, a semiaquatic ‘beaver-tailed otter-like’ mammaliaform from the now-extinct order Docodonta 2. Because C. lutrasimilis already featured prominent pelage, with long guar