정지영 교수

A wide variety of delivery systems have beendeveloped and many products based on the drug deliverytechnology are commercially available. The developmentof controlled-release technologies accelerated new dosageform design by altering pharmacokinetic and pharmacodynamicsprofiles of given drugs, resulting in improvedefficacy and safety. Various natural or synthetic polymershave been applied to make matrix, reservoir or implantforms due to the characteristics of polymers, especiallyease of control f

Five varieties of Piper betle L. var. leaves including Bangla, Sanchi, Misti, Khasia, and BARI Paan 3 from Bangladesh were subjected to the analysis of their volatile compounds. Simultaneous distillation extraction (SDE) with 1:1 (v/v) n-pentane:diethylether was used for the isolation of the volatile compounds while the analysis was done by gas chromatography/mass spectrometry (GC/MS). From the results, the Misti betel leaf variety showed the highest concentration of volatile compounds (13959 mg

Kimchi is a traditional Korean salted spontaneous lactic acid bacteria (LAB)-fermented food made using various vegetables. Organic acids, free sugars, and amino acids are key metabolites produced during LAB fermentation that determine the taste and quality of kimchi. However, each metabolite is typically analyzed using an independent analytical method, which is time-consuming and expensive. Therefore, in this study, we developed a method based on LC-Q-Orbitrap MS using which 20 types of represen

Abstract This study was designed to analyze the volatile organic compounds in the leaves of Ambrosia artemisiifolia L. and Artemisia annua L. from Korea. For extraction of volatile compounds, headspace-solid phase micro extraction (HS-SPME) and simultaneous distillation extraction (SDE) were applied and analyzed by gas chromatography/mass spectrometry (GC/MS). From the results, SDE extraction was found to give the highest concentration of volatile compounds with an average concentration of 1,237

이 연구는 2005년부터 공공보건기관에서 시행중인 한의약건강증진Hub보건소사업의 효율성을 자료포락분석을 이용하여 평가하였으며, 각 한의약건강증진Hub보건소간 효율성 차이의 원인을 밝히고자 하였다. 또한 그 동안 자료포락분석을 이용한 연구에서 한계점으로 지적되어 온 질적 측면을 고려하지 못한 문제를 극복하기 위하여 고객만족비율을 분석모형에 포함시켜 그 적용가능성을 검토하였다. 이 연구에서는 자료포락분석을 위한 투입변수로 Hub보건소 한의약건강증진사업 총예산과 행정안전부 합동평가지표에서 사용된 인력의 적절성 합계점수를 사용하였고 산출변수로는 총 참여주민 수, 한방진료실 총 내원환자 수, 한의약공공보건사업 만족/매우 만족 비율을 사용하였다. 연구결과 분석모형에 포함된 51개 보건소 중 CCR모형에서는 9개의 보건소가 BCC모형에서는 15개의 보건소가 효율적인 보건소로 나타났으며, BCC모형에 의한 기술적 순효율성 결과가 더 높게 나타나 규모의 비효율성이 존재하는 것으로 나타났다. 그리고

Garlic ( Allium sativum ) is a key ingredient in Korean cuisine, particularly in the preparation of kimchi, contributing to its flavor and taste. Garlic has been a potential resource for lactic acid bacteria (LAB) in kimchi. However, the mechanism by which it influences microbial diversity and metabolite production is unclear. This study investigated the effect of garlic on the bacterial composition of and metabolite changes in kimchi. To achieve this, four separate batches of kimchi were prepar

Recent studies utilizing deep convolutional neural networks (CNN) have described the central venous catheter (CVC) on chest radiography images. However, there have been no studies for the classification of the CVC tip position with a definite criterion on the chest radiograph. This study aimed to develop an algorithm for the automatic classification of proper depth with the application of automatic segmentation of the trachea and the CVC on chest radiographs using a deep CNN. This was a retrospe

Piper betle L. (betel) is largely consumed for mastication, mouth freshening, and medicinal purposes throughout the world. This study reports the authentication of Piper betle L. var.; Bangla, Sanchi, Misti, Khasia, and BARI Paan 3. The samples were analyzed for Ca, P, K, Mg, Na, Zn, Fe, Cr, Mn, Ni, Cu, Sr, Ba, Li, Be, V, Co, Ga, Se, U, Cs, As, Cd, Tl, and Pb by inductively coupled plasma – optical emission spectrometry (ICP-OES) and ICP – mass spectrometry (ICP-MS). Among the macro elements, th

N -Lactoyl-phenylalanine (Lac-Phe) is a metabolite known for its appetite-suppressing and antiobesity properties, while phenyllactic acid (PLA) is recognized for its antibacterial activity. Both metabolites are derived from phenylalanine and lactic acid metabolism through peptidase and dehydrogenase activities. The aim of this study was to investigate the production of Lac-Phe and PLA in kimchi, focusing on the role of lactic acid bacteria (LAB). Ultrahigh performance liquid chromatography coupl

In view of their rich mineral content and flavor, kimchi cabbage leaves and roots have high nutritional and medicinal values. In this study, we quantified major nutrient (Ca, Cu, Fe, K, Mg, Na, and Zn), trace (B, Be, Bi, Co, Ga, Li, Ni, Se, Sr, V, and Cr), and toxic (Pb, Cd, Tl, and In) elements in kimchi cabbage cultivation soil, leaves, and roots. The analysis method relied on inductively coupled plasma-optical emission spectrometry for major nutrient elements and inductively coupled plasma-ma

This study was conducted to compare the volatile flavor compounds of Artemisia annua L. after extraction by simultaneous steam distillation extraction (SDE) and solid-phase micro extraction (SPME) followed by gas chromatography-mass spectrometry (GC-MS) analysis. Via SDE and SPME processes, 79 (1,254.00 mg/kg) and 39 (488.74 mg/kg) compounds were identified respectively. The compounds extracted by SDE included 27 alcohols, 13 aldehydes, 22 hydrocarbons, 3 esters, 12 ketones, 1 oxide and 1 N-cont