신지영 교수

RATIONALE: Phosphate (Pi) is an essential nutrient to living organisms. Recent surveys indicate that the intake of Pi has increased steadily. Our previous studies have indicated that elevated Pi activates the Akt signaling pathway. An increased knowledge of the response of lung cancer tissue to high dietary Pi may provide an important link between diet and lung tumorigenesis. OBJECTIVES: The current study was performed to elucidate the potential effects of high dietary Pi on lung cancer developm

BACKGROUND: We investigated whether Makorin ring finger protein 1 (MKRN1), an E3 ligase, affects p14ARF-associated cellular senescence and tumorigenesis by posttranslational modification in gastric tumorigenesis. METHODS: A link between MKRN1 and ARF was examined in MKRN1 null mouse embryonic fibroblasts (MEFs) and in human fibroblasts and gastric cancer cells by silencing MKRN1 using small interfering RNA (siRNA) and short hairpin RNA (shRNA). Ubiquitination and proteasomal degradation assays w

MicroRNAs (miRNAs) play a critical role in gastric cancer progression and metastasis. This study investigated the role of miRNA-135a in early gastric cancer (EGC) including lymph node (LN) metastasis. We examined the correlation between miRNA-135a expression and clinical outcomes in 59 patients who underwent surgery for EGC. Using gastric cancer cell lines, we performed functional and target gene analyses. miRNA-135a expression was down-regulated in 33.9% of patients. These patients showed a sig

Obesity in working adults was associated with > 50 years of age and long working hours in women. Further studies are needed to investigate the underlying mechanisms of this relationship and its potential implications for the prevention and management of excess weight and obesity.

오프라인에서 이미 친밀한 관계가 형성된 사람들이 온라인에서 개인 정보를 공유하면서 사회적 긴밀 관계를 유지해가는BLOG가 한국에서 상당한 인기를 유지하고 있다. 그러나, 이러한 개인 정보의 공유는, BLOG에서 회원들을 유지하는 동기요인이면서 동시에 BLOG에서 회원들이 이탈할 수 있는 위험 요인을 동시에 갖고 있는 이중적인 의미를 갖고 있다. 본연구는, 어떠한 유형의 개인 정보가 BLOG에서 교환되고 있으며, 과연 이러한 개인 정보의 교환이 BLOG에서 프라이버시에 대한 염려를 증가시키는 부정적인 영향이 있는지를 실증 분석 하였다. 아울러, 이러한 개인 정보의 유출 위험이 프라이버시 염려에 대한 영향을 조절하는 두 가지 조절변수에 대한 효과도 검증한다. 개인정보는 BLOG의 매력이자 동시에위험인 이중적인 의미가 내포되어 있으며, BLOG 호스트와 방문자에 따라 민감한 개인정보의 유형에 다소 차이가 발견되었다. 결론적으로, BLOG 회원들에게 개인정보 공개에 대한 통제력이 주어져야

Broussonetia papyrifera (L.) Vent. and Lonicera japonica Thunb. have been used in recent medicinal research for their antioxidative and anti-inflammatory properties. The present study investigated the therapeutic efficacy of B. papyrifera and L. japonica ethanolic extracts in a murine model of ovalbumin-induced asthma, in which intra-peritoneal (IP) injections and aerosol ovalbumin delivery were used to induce allergic asthma. Bronchioalveolar lavage fluid (BALF), serum samples, lungs and livers

The bone density fractionation method is a potential palaeodietary tool in tracing lifetime dietary changes as well as separating diagenetically altered fractions. This paper presents a workable bone density fractionation method that uses a devised mathematical model and the particle size distribution. Different grinding methods, i.e., a Spex LN2 mill, a Disc mill and a Micronising mill, were used to reduce archaeological bone particles to an appropriate size range, which was then analyzed by a

Background The genetic structure of marine organisms in the East Asian region has long been a subject of interest. Two grapsid crab species, Hemigrapsus penicillatus (De Haan, 1835) and Hemigrapsus sanguineus (De Haan, 1835), are commonly found in the rocky intertidal zones around this region. They are known to spread via larval migration, which makes them an appropriate model species for observing the genetic structure of East Asian intertidal invertebrate animals. Objective We investigated the

이 논문은 나혜석의 풍경화를 여행과 공간의 성 정치라는 여성주의적 의미로 성찰한 글이다. 1990년대 우리 사회의 여성주의의 부상 이래 나혜석에 대한 연구가 활발해 졌다. 그러나 문학에서나 삶에서 확인되었던 나혜석의 여성주의를 회화에서는 찾기 어려웠다. 이는 나혜석의 회화가 주로 풍경화를 중심으로 하고 있고 그것도 서구 풍경화가 많기 때문이다. 일반적으로 인상주의로 분류되는 나혜석의 풍경화는 이국적 풍경으로 ‘서구 지향적’, ‘부로조아적’이라는 평가를 받았다. 기존의 연구와 달리 이 논문은 나혜석의 회화를 공사담론, 섹슈얼리티, 여성성 등의 여성주의 인식론을 기반으로 새롭게 해석한다. 이 논문은 여성주의 뿐 아니라 1970년대 이후 부상하였던 서구의 여성주의 미술사도 소개하는데 나혜석 회화가 자리 매김되던 인상주의 회화의 젠더 이데올로기가 공사담론에 비추어 지적하는 여성주의 인식론의 발전을 보이고 있기 때문이다. 풍경화를 중심으로 하는 나혜석의 회화는 내외라는 유교적 법도에 의해 여

This paper presents a stable isotope chemistry of bone collagen and carbonate. Bone carbonate has the potential to provide additional isotopic information. However, it remains controversial as to whether archaeological bone carbonate retains its original biogenic signature. I used a novel application of bone density fractionation and checked the integrity of <TEX>${\delta}^{13}C_{apa}$</TEX> values using radiocarbon dating. Diagenesis in archaeological bone carbonate still remains to be resolved

It is well known that Nuo was a national annual event that servedthe mysterious role of strengthening national unity as a calendricalapotropaic ritual in the court. It is especially meaningful in that thiscyclical ritual with folk religious characteristics was combined withdrama to be performed in court as Court Drama every year on a regularbasis. Considering that it served as a regular venue to express collectiveappreciation and to pray for wishes such as keeping away evil spirits inthe respect

Zhong Yi Xuan Tu, a full length court drama written during the QingDynasty, has been considered as an indistinctive literary work with themajority of its contents simply adopted from The Water Magin, or ShuihuZhuan, a classical novel. However, the work should rather be analyzedas a drama than as a novel since it was developed to serve the purposeof a play to be put on a massive 3-story stage inside the court. Thepurpose of this paper is to clarify that Zhong Yi Xuan Tu is not a mereadoption of t