정지현 교수

BACKGROUND: Coronary microvascular dysfunction (CMD) is an important contributor to angina syndromes. Recently, two distinct endotypes were identified using combined assessment of coronary flow reserve (CFR) and minimal microvascular resistance (MR), termed structural and functional CMD. AIMS: We aimed to assess the relevance of the combined assessment of CFR and MR in patients with angina and no obstructive coronary arteries. METHODS: Patients with chronic coronary syndromes (CCS) and non-obstr

PURPOSE: This study was conducted to investigate the distributions of the triglyceride (TG) to high-density lipoprotein-cholesterol (HDL-C) ratio and total cholesterol (TC) to HDL-C ratio, and to explore their usefulness as markers of metabolic syndrome (MetS) in Korean adolescents. METHODS: We obtained data for 2,721 adolescents (1,436 boys and 1,285 girls) aged 10-18 years who participated in the Korean National Health and Nutrition Examination Surveys from 2008 to 2010. International Diabetes

Liver sinusoidal endothelial cells (LSECs) are highly specialized and involved in hepatic regeneration by interacting with hepatic stellate cells (HSCs) and hepatocytes in a paracrine manner. However, hepatic injury can impair cellular activity and lead to endothelial dysfunction, eventually inducing the development of critical hepatic disease, including cirrhosis. Because LSECs exert their effects through paracrine factors, maintenance of paracrine potentials and survival activity in LSECs unde

Inclusive Invasive Physiological Assessment in Angina Syndromes Registry (ILIAS Registry), NCT04485234.

Purpose: Respiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infection (LRTI) in infants and children. We investigated the association of meteorological conditions and air pollution with the prevalence of RSV infection. Methods: Between January 2005 and December 2012, a total of 9,113 nasopharyngeal swab specimens from children under 3 years of age who were admitted to the hospital with acute LRTI were tested for RSV antigens using a direct immunofluorescence ki

Protease-activated receptor (PAR)-2 is expressed in endothelial cells and vascular smooth musclecells. It plays a crucial role in regulating blood pressure via the modulation of peripheral vasculartone. Although some reports have suggested involvement of a neurogenic mechanism in PAR-2-inducedhypotension, the accurate mechanism remains to be elucidated. To examine this possibility, weinvestigated the effect of PAR-2 activation on smooth muscle contraction evoked by electrical fieldstimulation (E

BACKGROUND: Microvascular resistance (MR) has prognostic value in acute and chronic coronary syndromes following percutaneous coronary intervention (PCI), however anatomic and physiologic determinants of the relative changes of MR and its association to target vessel failure (TVF) has not been investigated previously. This study aims to evaluate the association between changes in MR and TVF. METHODS: This is a sub-study of the Inclusive Invasive Physiological Assessment in Angina Syndromes (ILIA

Background: Sarcopenia has become a major concern owing to its association with a high risk of fall or fracture and metabolic impairments. There is insufficient evidence to support the role of dietary protein intake in reducing the prevalence of sarcopenia. This study was conducted to investigate the variation in low skeletal muscle index (SMI) with the dietary levels of protein intake. Methods: This study analyzed data of 3,482 male and 4,838 female aged 50 years or older from the Korean Nation

The protease-activated receptor (PAR)-2 is highly ex-pressed in endothelial cells and vascular smooth muscle cells. It plays a crucial role in regulating blood pressure via the modulation of peripheral vascular tone. Although several mechanisms have been suggested to explain PAR-2-induced hypotension, the precise mechanism remains to be elucidated. To investigate this possibility, we investigated the effects of PAR-2 activation on N-type Ca2+ currents (ICa-N) in isolated neurons of the celiac ga

Spontaneous myometrial contraction (SMC) in pregnant uterus is greatly related with gestationalage and growing in frequency and amplitude toward the end of gestation to initiate labor. But, anaccurate mechanism has not been elucidated. In human and rat uterus, all TRPCs except TRPC2 areexpressed in pregnant myometrium and among them, TRPC4 are predominant throughout gestation,suggesting a possible role in regulation of SMC. Therefore, we investigated whether the TRP channelmay be involved SMC ev

The MRR seems to be equally applicable in both women and men with stable coronary artery disease.

본 연구는 시각 장애 전문 무용수를 위한 예술 보조 기술 개발에 필요한 가이드를 제안하는 것을 목표로 한다. 이는 시각 장애인의 문화향유 증진과 예술 창작 및 교육 활동을 지원하기 위한 목적을 가지고 있다. 이를 위해 먼저 기존의 시각 장애인을 위한 보조 장비 사례를 살펴보았다. 이후, 장비 개발 시 고려해야 할 주요 사항을 분석하기 위해 시각 장애 전문 무용수들을 대상으로 반구조화 인터뷰를 진행하였다. 또한, 이들의 요구를 반영하여 개발한 기술 장비를 사용하여 사용자 테스트를 진행하고 실제 공연 연출에 적용하여 문제점과 해결 방안을 도출하였다. 연구 결과, 시각 장애 무용수들이 감각적 및 신체적 제약으로 인해 학습과 창작 과정에서 큰 어려움을 겪고 있다는 사실을 확인할 수 있었다. 이러한 문제를 해결하기 위해 본 논문에서는 멀티모달 다감각 지원 기술을 제시한다.