최진호 교수

CONTEXT: Mutations in the IGF1R gene result in intrauterine growth retardation and postnatal growth failure. OBJECTIVE: The objective of this study was to describe the clinical features of subjects with a mutation in the IGF1R gene and to evaluate the molecular and functional characteristics of a novel IGF1R mutation. SUBJECTS: Three children with unexplained intrauterine growth retardation (birth weight <-1.5 SD score) and persistent short stature (<-2.0 SD score) were included in the study. ME

Background Recently the potential of myocardial repair by transplantation of autologous bone marrow stem cells has been suggested. Whether the additional intracoronary transplantation of autologous peripheral blood stem cells (PBSC), which were mobilized by granulocyte-colony-stimulating factor (G-CSF), could safely improve myocardial function in patients with acute myocardial infarction (AMI) was investigated. Methods and Results Seventy-three patients with AMI who had successfully undergone pe

We investigate an adaptive subcarrier, bit, and power allocation algorithm for the downlink MIMO-OFDMA system. Using the singular value decomposition, the MIMO fading channel of each subcarrier is transformed into an equivalent bank of parallel SISO sub-channels. For the efficient allocation of the banks of parallel sub-channels, we define the problem of minimizing total transmit power with constraints on BER and transmission rate for users. Using the simplified problem formulation, we propose a

Sounding provides a BS with knowledge of the channel state information of a user in an orthogonal frequency division multiple access (OFDMA) full duplex division (FDD) uplink. In this paper, we propose a novel sounding subband allocation algorithm for the proportional fair (PF) scheduler. Simulation results show that our proposed sounding method enables the PF scheduler to achieve the throughput gain and guarantee fairness at the same time.

There are various methods for approaching the aortic arch, such as median sternotomy or lateral thoracotomy. However, accessing the site of distal anastomosis is problematic when the distal arch is extensively involved. We report a case of extended aortic arch replacement and coronary artery bypass through the L-incision approach.

BACKGROUND: In percutaneous coronary intervention, drug-eluting stent (DES) showed better clinical outcome compared to bare-metal stent (BMS) but mostly with different DAPT durations. HYPOTHESIS: The clinical superiority of DES over BMS may depend on the medication adherence to dual antiplatelet therapy (DAPT). METHODS: We retrospectively enrolled all Koreans PCI patients in year 2011 (n = 47,291). Medication adherence to DAPT was assessed by proportion of days covered (PDC) per 6 months. Analys

5-HT2A is one of major serotonin receptor that is involved in the action of serotonin-targeting drugs. Previous clinical studies have shown an unexpected association between lower cholesterol level and psychiatric diseases, in which T102C polymorphism of HTR2A, gene of 5-HT2A serotonin receptor, might be involved. Therefore, we hypothesized a potential association between lower cholesterol level and T102C polymorphism. The effect of the T102C polymorphism on the serum lipid profiles of 646 sub

Purpose: We assessed the impact of treatment modalities, such as radical prostatectomy or external beam radiation therapy, for prostate cancer on the health related quality of life(HRQoL) and sexual function of patients. Materials and Methods: 137 eligible patients, with localized or locally advanced prostate cancer, were enrolled from two treatment groups: radical prostatectomy(RP) and external beam radiation therapy(EBRT). To compare changes in the HRQoL and sexual function after treatment wit

OBJECTIVES: Mortality following percutaneous coronary intervention (PCI) is a key quality measurement in clinical practice. This study investigated the 10-year trends of mortality following PCI in an unselected nationwide cohort. DESIGN: Retrospective cohort study. SETTING: A nationwide study in South Korea. PARTICIPANTS: PCI claim data from 2006 to 2015 of the National Health Insurance Service and the Statistics of Korea. MEASURES: 1-year cardiovascular or non-cardiovascular death. RESULTS: In

In this real-world data analysis, patients taking FDC of ARB and statin showed higher medication persistence and adherence compared to patients taking FC of ARB and statin up to 540 days. The risk of all-cause death was not different between FDC and FC despite better medication compliance in the FDC patients.