조진만 교수

OBJECTIVES: The purpose of this document is to make the output of the International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available to medical and scientific communities, through a peer-reviewed publication, in the interest of improving the diagnosis and treatment of patients with atherosclerosis, including coronary artery disease. BACKGROUND: Intravascular optical coherence tomography (IVOCT) is a catheter-based modality that acq

Among patients with complex coronary-artery lesions, intravascular imaging-guided PCI led to a lower risk of a composite of death from cardiac causes, target-vessel-related myocardial infarction, or clinically driven target-vessel revascularization than angiography-guided PCI. (Supported by Abbott Vascular and Boston Scientific; RENOVATE-COMPLEX-PCI ClinicalTrials.gov number, NCT03381872).

BACKGROUND: Optical coherence tomography (OCT) was recently introduced to optimize percutaneous coronary intervention. However, the exact incidence and significance of poststent OCT findings are unknown. METHODS AND RESULTS: A total of 900 lesions treated with 1001 stents in 786 patients who had postprocedure OCT imaging were analyzed to evaluate the incidence of poststent OCT findings and to identify the OCT predictors for device-oriented clinical end points, including cardiac death, target ves

Renal denervation is a promising new non-pharmacological treatment for resistant hypertension. However, there is a lack of data from Asian patients. The REQUIRE trial investigated the blood pressure-lowering efficacy of renal denervation in treated patients with resistant hypertension from Japan and South Korea. Adults with resistant hypertension (seated office blood pressure ≥150/90 mmHg and 24-hour ambulatory systolic blood pressure ≥140 mmHg) with suitable renal artery anatomy were randomized

OBJECTIVE: Plaque rupture may be the local expression of a widespread coronary instability. This study aimed to investigate: (1) the prevalence and characteristics of nonculprit plaque rupture; (2) the pancoronary atherosclerotic phenotype in patients with and without nonculprit plaque rupture; and (3) the prevalence and predictors of multiple plaque ruptures. APPROACH AND RESULTS: Six hundred and seventy-five nonculprit plaques from 261 patients (34 acute myocardial infarction, 73 unstable angi

BACKGROUND: The objective of this study was to assess the efficacy of intra-articular injections of hyaluronic acid (HA) and a novel, on-site conjugate of HA with autologous fibrinogen in platelet-rich plasma (HA-PRP) in a canine model of osteoarthritis (OA) METHODS: Twelve beagle dogs underwent a unilateral resection of the cranial cruciate ligament (CrCL) of the stifle joint. Clinical and radiographic signs of OA were confirmed in all dogs 8 weeks following CrCL resection and prior to treatmen

목적 : 관상동맥 질환은 이미 한국인의 주요 사망원인으로 증가일로에 있지만 그에 대한 자세한 역학적, 인구학적인 통계가 부족한 실정이다. 저자 등은 전향적인 대규모 임상연구를 통해 관동맥 질환의 임상양상과 치료실태, 예후 등을 알아보고자 하였다. 방법 : 1999년 12월부터 2003년 4월까지 가톨릭의대 8개 부속 병원에 입원하여 관동맥 질환을 진단받은 1,665명을 대상으로 임상양상을 조사하였으며, 2003년 9월까지 추적관찰이 가능하였던 965명을 대상으로 예후에 영향을 미치는 인자에 대하여 분석하였다. 결과 : 관동맥 질환으로 입원한 환자의 진단명은 급성심근경색증이 가장 많았고, 관동맥 질환의 위험인자들 중 고혈압, 흡연, 당뇨병 등의 빈도가 높았다. 이상지혈증은 1,151명에서 관찰되어 비교적 높은 유병률을 보였으나, 주요 심장사건의 event-free survial에 영향을 미치는 독립적인 인자가 아니었다. 1,665명 중 1,217명에서 관동맥 조영술을 시행한 결과, 단