김진아 교수

Objective: Permeability parameters from dynamic contrast-enhanced MRI (DCE-MRI) and apparent diffusion coefficient (ADC) value on diffusion-weighted imaging (DWI) can be quantitative physiologic metrics for gliomas. The transfer constant (Ktrans) has shown efficacy in grading gliomas. Volume fraction of extravascular extracellular space (ve) has been underutilized to grade gliomas. The purpose of this study was to evaluate ve in its ability to grade gliomas and to assess the correlation with oth

Purpose: To investigate the correlation between gadolinium enhanced magnetic resonance image (MRI) results and surgical findings of facial nerves in Bell’s palsy and Ramsay Hunt syndrome. Materials and Methods: From 1995 to 2004, MRI was performed on 13 patients with Bell’s palsy or Ramsay Hunt syndrome, who were offered with surgical decompression of the facial nerve through the middle cranial fossa approach. Gadolinium enhanced MRI was performed on all patients and the enhancement of the facia

Sorafenib, originally identified as an inhibitor of multiple oncogenic kinases, induces ferroptosis in hepatocellular carcinoma (HCC) cells. Several pathways that mitigate sorafenib-induced ferroptosis confer drug resistance; thus strategies that enhance ferroptosis increase sorafenib efficacy. Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is upregulated in human HCC tissues and plays a role in cancer cell proliferation. The aim of this study was to determine whether inhibition of E

Purpose: To achieve maximal safe resection during brain tumor surgery, functional image-merged neuronavigation is widely used. We retrospectively reviewed our casesin which diffusion tensor image (DTI)-merged functional neuronavigation was performed during surgery. Materials and Methods: Between November 2008 and May 2010, 123 patients underwent surgery utilizing DTI-merged neuronavigation. Anatomical magnetic resonance images (MRI) were obtained preoperatively and fused with DTI of major white

Purpose: Mitochondrial encephalopathy (ME) is a rare disorder of energy metabolism. The disease course can roughly be evaluated by clinical findings. The purpose of this study was to evaluate metabolic spectral changes using proton MR spectroscopy (MRS), and to establish a way to monitor ME by neuroimaging. Materials and Methods: Proton MRS data were retrospectively reviewed in 12patients with muscle biopsy-confirmed ME (M : F = 7 : 5, Mean age = 4.8 years). All received 1H-MRS initially and als

This study aimed to investigate the efficacy of liver-directed concurrent chemoradiotherapy (LD-CCRT) compared with sorafenib in patients with liver-confined locally advanced hepatocellular carcinoma (HCC) presenting portal vein tumor thrombosis (PVTT). This single institute retrospective cohort study included patients treated with sorafenib or LD-CCRT between 2005 and 2016. Patients with extrahepatic disease and those without PVTT were excluded, leaving 28 and 448 patients in the sorafenib and

The purpose of this study was to evaluate the diagnostic performance of magnetic resonance (MR) radiomics-based machine learning algorithms in differentiating squamous cell carcinoma (SCC) from lymphoma in the oropharynx. MR images from 87 patients with oropharyngeal SCC (n=68) and lymphoma (n=19) were reviewed retrospectively. Tumors were semi-automatically segmented on contrast-enhanced T1-weighted images registered to T2-weighted images, and radiomic features (n=202) were extracted from contr

본 연구는 학교스포츠클럽 활동 무용수업 참여자들의 감성지능, 신체적 자기효능감, 학교적응 간의 관계를 규명하는 것이며 학교스포츠클럽 활성화를 위한 기초자료를 제공하는 데 있다. 연구의 목적을 달성하기 위해 중학생 226명의 설문지를 사용하였다. 빈도분석, 탐색적 요인분석, 신뢰도 분석, 상관관계분석, 다중회귀분석을 통해 분석되었다. 첫째, 감성지능의 하위요인은 신체적 자기효능감의 하위요인인 인지된 신체능력과 신체적 자기표현 자신감에 정적인 영향을 미치는 것으로 나타났다. 둘째, 신체적 자기효능감의 하위요인인 인지된 신체능력은 학교적응의 모든 하위요 인에 정적인 영향을 미치는 것으로 나타났다. 셋째, 감성지능의 하위요인인 타인감성이해, 감성의 활용, 자기감성이해는 학교적응의 하위요인인 학교친구, 학교교사, 학교규칙 및 환경, 학교수업에 정적인 영향을 미치는 것으로 나타났다. 본 연구결과를 통해 향후 학교스포츠클럽 무용수업에 관한 연구에 기초자료가 되었으면 한다.

Purpose: Although systemic treatment is the mainstay for advanced hepatocellular carcinoma (HCC), numerous studies have highlighted the added value of local treatment. This study aimed to investigate the clinical efficacy of liver-directed combined radiotherapy (LD combined RT) compared with that of sorafenib, a recommended treatment until recently for locally advanced HCC presenting portal vein tumor thrombosis (PVTT), using a multinational patient cohort. Materials and Methods: We identified p

Various manifestations of brain involvement for patients with virus-associated hemophagocytic syndrome have been reported. Here, we report on the sequential magnetic resonance (MR) findings of acute demyelination of the entire brain with subsequent brain atrophy in a follow-up study of a 25-month- old boy who was admitted with fever and then diagnosed with infectious mononucleosis and EBV-associated hemophagocytic syndrome. We also review other conditions that should be included in the different

목적: 국내에서 개발된 비이온성 조영제인 Pamirayⓡ 300(Iopamidol; Dongkook Pharm., Seoul, Korea)의 뇌 혈관조영술에서의 임상적 안정성 및 유용성을 평가하고자 한다. 대상과 방법: 2005년 4월부터 9월까지, 서면 동의를 받은 100명의 환자를 대상으로 Pamiray ⓡ 300을 사용하여 뇌 혈관조영술을 시행하였다. 발열감, 통증 등 경도(minor)의 부작용과 호흡 곤란, 후두부종, 쇼크 등 심각한(major) 부작용, 두 집단으로 분류하여 부작용의 발생 빈도를 조사하였고, 부작용 발생과 환자들의 성, 연령, 진단명, 기저 질환 유무, 조영제 투여량과의 상관 관계를 평가하기 위해 로지스틱 회귀 분석(Logistic regression analysis)을 실시하였다. 독립된 3명의 영상의학과 전문의가 영상의 질을 5단계(불량, 불충분, 충분, 좋음, 우수)로 평가하였다. 결과: 모든 환자에게 시술 전과 후에 시행한 혈압, 심전도, 호흡수, 혈

Objective: Many diffusion tensor imaging (DTI) studies of the corpus callosum (CC) have been performed with a relatively thick slice thickness in the axial plane, which may result in underestimating the fractional anisotropy (FA) of the CC due to a partial volume effect. We hypothesized that the FA of the CC can be more accurately measured by using mid-sagittal DTI. We compared the FA values of the CC between the axial and mid-sagittal DTI. Materials and Methods: Fourteen healthy volunteers unde