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이주희 교수

Joo-Hee Lee

연세대학교 의생명과학부 · 의학

연구실 소개

이주희 교수의 연구실은 노화와 관련된 만성 염증 상태인 '인플레이나징(inflammaging)'과 그가 유도하는 피부 노화, 특히 손상 복구 과정에서의 염증 반응 조절 메커니즘을 중심으로 연구를 진행하고 있습니다. 주로 피부 세포의 노화(세포 노화)와 관련된 염증 매개 단백질(HMGB-1 등)의 역할을 규명하고, 이를 바탕으로 피부 재생 및 흉터 형성 억제를 위한 신규 치료 전략(예: PDRN, 히알루론산 젤)을 개발하고 있습니다. 또한 피부 및 점막의 만성 염증성 병변(예: 아구선성 구강염, 여드름 흉터)에 대한 비침습적 치료법의 유효성과 안전성도 평가하고 있습니다.

인플레이나징피부 노화흉터 형성HMGB-1PDRN

연구 현황

논문 수
505
총 인용 수
13,236
최근 5년 논문
68
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
68총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
942총합
20222023202420252026

주요 논문

15
1
리뷰|인용수 361·2008
Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis
Joo-Hee Lee, David Seto, Leonard Bielory
SJR Q1Journal of Allergy and Clinical ImmunologyOA
DermatologyMedicine
2
리뷰|인용수 203·2020
Debriefing methods and learning outcomes in simulation nursing education: A systematic review and meta-analysis
JuHee Lee, Hyejung Lee, Sue Kim, Sue Kim, Mona Choi, Il Sun Ko, Juyeon Bae, Sung Hae Kim, Sung Hae Kim
SJR Q1Nurse Education TodayOA
PhysiologyMedicine
3
리뷰|인용수 186·2021
Cellular Senescence and Inflammaging in the Skin Microenvironment
Young In Lee, Sooyeon Choi, Won Seok Roh, Ju Hee Lee, Tae‐Gyun Kim
SJR Q1International Journal of Molecular SciencesOA

Cellular senescence and aging result in a reduced ability to manage persistent types of inflammation. Thus, the chronic low-level inflammation associated with aging phenotype is called "inflammaging". Inflammaging is not only related with age-associated chronic systemic diseases such as cardiovascular disease and diabetes, but also skin aging. As the largest organ of the body, skin is continuously exposed to external stressors such as UV radiation, air particulate matter, and human microbiome. I

DermatologyMedicine
4
논문|인용수 109·2011
Comparison of complications after laparoscopy-assisted distal gastrectomy and open distal gastrectomy for gastric cancer using the Clavien–Dindo classification
JuHee Lee, Do Joong Park, Hyung‐Ho Kim, Hyuk-Joon Lee, Han-Kwang Yang
SJR Q1Surgical Endoscopy
Pulmonary and Respiratory MedicineMedicine
5
논문|인용수 103·2012
Effects of VEGF and FGF-2 on proliferation and differentiation of human periodontal ligament stem cells
Joo-Hee Lee, Soyoun Um, Jun‐Hyeog Jang, Byoung‐Moo Seo
SJR Q1Cell and Tissue Research
UrologyMedicine
6
리뷰|인용수 94·2016
A meta-analysis of the effects of non-traditional teaching methods on the critical thinking abilities of nursing students
JuHee Lee, Yoonju Lee, SaeLom Gong, Juyeon Bae, MoonKi Choi
SJR Q1BMC Medical EducationOA

This research showed that new teaching and learning methods designed to improve critical thinking were generally effective at enhancing critical thinking dispositions.

EducationSocial Sciences
7
논문|인용수 94·2017
Scar Prevention and Enhanced Wound Healing Induced by Polydeoxyribonucleotide in a Rat Incisional Wound-Healing Model
Woonhyeok Jeong, Chae Eun Yang, Tai Suk Roh, Jihee Kim, Ju Hee Lee, Won Jai Lee
SJR Q1International Journal of Molecular SciencesOA

High-mobility group box protein-1 (HMGB-1) plays a central role in the inflammatory network, and uncontrolled chronic inflammation can lead to excessive scarring. The aim of this study was to evaluate the anti-inflammatory effects of polydeoxyribonucleotide (PDRN) on scar formation. Sprague-Dawley rats (n = 30) underwent dorsal excision of the skin, followed by skin repair. PDRN (8 mg/kg) was administered via intraperitoneal injection for three (PDRN-3 group, n = 8) or seven (PDRN-7 group, n = 8

RehabilitationMedicine
8
논문|인용수 92·2015
Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization
Cheol Hwangbo, Nara Tae, S Lee, O Kim, Ok Kyu Park, Jinwoong Kim, S-H Kwon, Ju Hee Lee
SJR Q1Oncogene
Cell BiologyBiochemistry, Genetics and Molecular Biology
9
논문|인용수 92·2012
Esophageal Diameter Is Decreased in Some Patients With Eosinophilic Esophagitis and Might Increase With Topical Corticosteroid Therapy
Joo-Hee Lee, James E. Huprich, Christine Kujath, Karthik Ravi, Felicity Enders, Thomas C. Smyrk, David A. Katzka, Nicholas J. Talley, Jeffrey A. Alexander
SJR Q1Clinical Gastroenterology and Hepatology
SurgeryMedicine
10
논문|인용수 89·2007
The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet's disease
Ju Hee Lee, JY Jung, Dongsik Bang
SJR Q1Journal of the European Academy of Dermatology and VenereologyOA

BACKGROUND: Hyaluronic acid (HA) is a primary component of the extracellular matrix, and the efficacy of HA on oral ulcers is rarely reported. OBJECTIVE: To observe the efficacy and safety of the topical application of 0.2% HA gel on recurrent oral ulcers and to compare its effects in patients with recurrent aphthous ulcers (RAU) and the oral ulcers of Behçet's disease (BD). MATERIALS AND METHODS: Thirty-three outpatients with recurrent oral ulcers were included in the study (17 patients: BD, 16

Cell BiologyBiochemistry, Genetics and Molecular Biology
11
논문|인용수 89·2015
Characterization and tissue incorporation of cross-linked human acellular dermal matrix
Ju Hee Lee, Hyung Goo Kim, Won Jai Lee
SJR Q1BiomaterialsOA
SurgeryMedicine
12
논문|인용수 74·2009
일 대학 간호대학생의 시뮬레이션 교육 경험 분석
이주희, 김소선, 여기선, 조수진, 김현례

Purpose: The purpose of this study was to explore experiences among undergraduate nursing students in a high-fidelity simulation education course for a semester. Method: The participants in this study were 10 nursing students in the senior classes and volunteers. Data collection was conducted using a focus group interview for 100 minutes, which was recorded on video tape. Transcribed data was analyzed through qualitative content analysis. Result: The results of this study were deduced as 4 codes

13
논문|인용수 70·2009
Comparison of a 1,550 nm Erbium:Glass fractional laser and a chemical reconstruction of skin scars (CROSS) method in the treatment of acne scars: A simultaneous split‐face trial
Hee Jung Kim, Tae‐Gyun Kim, Yeon Sook Kwon, Jin Mo Park, Ju Hee Lee
SJR Q1Lasers in Surgery and MedicineOA

BACKGROUND AND OBJECTIVE: Acne scarring is a common complication of acne but no effective single treatment modality has been developed. To compare the efficacy of 1,550 nm Er:Glass fractional laser and chemical reconstruction of skin scar (CROSS) method in the treatment of acne scars. STUDY DESIGN/MATERIALS AND METHODS: A split-face trial was conducted in 20 patients (10 rolling, 10 icepick types) with acne scars. One side was treated with the 1,550 nm Er:Glass fractional laser three times with

DermatologyMedicine
14
논문|인용수 67·2010
Glycoprotein 90K, downregulated in advanced colorectal cancer tissues, interacts with CD9/CD82 and suppresses the Wnt/β-catenin signal via ISGylation of β-catenin
Ju Hee Lee, Jeong A Bae, Ju Hee Lee, Young-Woo Seo, Dhonghyo Kho, Eun Gene Sun, S. E. Lee, Sang Hee Cho, Young‐Eun Joo, Kyu Youn Ahn, Ik‐Joo Chung, K. K. Kim
SJR Q1Gut

BACKGROUND AND AIMS: 90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell motility and its effect on CRC progression were investigated. METHODS: The impact of 90K was analysed by combining cell cultures, in vitro assays, and immunohistochemistry. RESULTS: Secreted 90K

ImmunologyImmunology and Microbiology
15
논문|인용수 66·2008
Efficacy of the Fractional Photothermolysis System with Dynamic Operating Mode on Acne Scars and Enlarged Facial Pores
Sung Bin Cho, Ju Hee Lee, Moon Jung Choi, Kyu-yeop Lee, Sang Ho Oh
SJR Q2Dermatologic SurgeryOA

We suggest that the FPS may provide a new treatment algorithm in some cases with acne scars and enlarged pores. Considering the lack of placebo-controlled, split-face design of our study, optimized, prospective studies should be conducted to fully assess the efficacy of FPS with dynamic operating mode.

DermatologyMedicine

대표 연구 분야

DermatologyPulmonary and Respiratory MedicineSurgeryOncologyCell BiologyPhysiology

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